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Dynamic Kinetic Asymmetric Synthesis of Substituted Pyrrolidines from Racemic Cyclopropanes and Aldimines: Reaction Development and Mechanistic Insights

Тип публикацииJournal Article
Дата публикации2010-06-24
scimago Q1
wos Q1
БС1
SJR5.489
CiteScore24.4
Impact factor15.6
ISSN00027863, 15205126
General Chemistry
Catalysis
Biochemistry
Colloid and Surface Chemistry
Краткое описание
An enantioselective preparation of 2,5-cis-disubstituted pyrrolidines has been achieved via a dynamic kinetic asymmetric transformation (DyKAT) of racemic donor-acceptor cyclopropanes and (E)-aldimines. Mechanistic studies suggest that isomerization of the aldimine or resultant iminium to the Z geometry is not a pathway that furnishes the observed 2,5-cis-disubstituted products.
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ГОСТ |
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Parsons A. T. et al. Dynamic Kinetic Asymmetric Synthesis of Substituted Pyrrolidines from Racemic Cyclopropanes and Aldimines: Reaction Development and Mechanistic Insights // Journal of the American Chemical Society. 2010. Vol. 132. No. 28. pp. 9688-9692.
ГОСТ со всеми авторами (до 50) Скопировать
Parsons A. T., Smith A., Neel A. J., Johnson J. S. Dynamic Kinetic Asymmetric Synthesis of Substituted Pyrrolidines from Racemic Cyclopropanes and Aldimines: Reaction Development and Mechanistic Insights // Journal of the American Chemical Society. 2010. Vol. 132. No. 28. pp. 9688-9692.
RIS |
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TY - JOUR
DO - 10.1021/ja1032277
UR - https://doi.org/10.1021/ja1032277
TI - Dynamic Kinetic Asymmetric Synthesis of Substituted Pyrrolidines from Racemic Cyclopropanes and Aldimines: Reaction Development and Mechanistic Insights
T2 - Journal of the American Chemical Society
AU - Parsons, Andrew T
AU - Smith, Austin G.
AU - Neel, Andrew J
AU - Johnson, Jeffrey S.
PY - 2010
DA - 2010/06/24
PB - American Chemical Society (ACS)
SP - 9688-9692
IS - 28
VL - 132
PMID - 20572661
SN - 0002-7863
SN - 1520-5126
ER -
BibTex |
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BibTex (до 50 авторов) Скопировать
@article{2010_Parsons,
author = {Andrew T Parsons and Austin G. Smith and Andrew J Neel and Jeffrey S. Johnson},
title = {Dynamic Kinetic Asymmetric Synthesis of Substituted Pyrrolidines from Racemic Cyclopropanes and Aldimines: Reaction Development and Mechanistic Insights},
journal = {Journal of the American Chemical Society},
year = {2010},
volume = {132},
publisher = {American Chemical Society (ACS)},
month = {jun},
url = {https://doi.org/10.1021/ja1032277},
number = {28},
pages = {9688--9692},
doi = {10.1021/ja1032277}
}
MLA
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Parsons, Andrew T., et al. “Dynamic Kinetic Asymmetric Synthesis of Substituted Pyrrolidines from Racemic Cyclopropanes and Aldimines: Reaction Development and Mechanistic Insights.” Journal of the American Chemical Society, vol. 132, no. 28, Jun. 2010, pp. 9688-9692. https://doi.org/10.1021/ja1032277.