Acyclic Chelate with Ideal Properties for 68Ga PET Imaging Agent Elaboration
Тип публикации: Journal Article
Дата публикации: 2010-10-19
scimago Q1
wos Q1
БС1
SJR: 5.489
CiteScore: 24.4
Impact factor: 15.6
ISSN: 00027863, 15205126
PubMed ID:
20958034
General Chemistry
Catalysis
Biochemistry
Colloid and Surface Chemistry
Краткое описание
We have investigated novel bifunctional chelate alternatives to the aminocarboxylate macrocycles NOTA (N3O3) or DOTA (N4O4) for application of radioisotopes of Ga to diagnostic nuclear medicine and have found that the linear N4O2 chelate H2dedpa coordinates 67Ga quantitatively to form [67Ga(dedpa)]+ after 10 min at RT. Concentration-dependent coordination to H2dedpa of either 68Ga or 67Ga showed quantitative conversion to the desired products with ligand concentrations as low as 10−7 M. With 68Ga, specific activities as high as 9.8 mCi nmol−1 were obtained without purification. In a 2 h competition experiment against human apo-transferrin, [67Ga(dedpa)]+ showed no decomposition. Two bifunctional versions of H2dedpa are also described, and these both coordinate to 67Ga at RT within 10 min. Complete syntheses, characterizations, labeling studies, and biodistribution profiles of the 67Ga complexes are presented for the new platform chelates. The stability of these platform chelates is higher than that of DOTA.
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Метрики
132
Всего цитирований:
132
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(3.79%)
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MLA
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ГОСТ
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Boros E. et al. Acyclic Chelate with Ideal Properties for 68Ga PET Imaging Agent Elaboration // Journal of the American Chemical Society. 2010. Vol. 132. No. 44. pp. 15726-15733.
ГОСТ со всеми авторами (до 50)
Скопировать
Boros E., Ferreira C. L., Cawthray J., Price E. W., Patrick B. N., Wester D. W., Adam M. J., Orvig C. Acyclic Chelate with Ideal Properties for 68Ga PET Imaging Agent Elaboration // Journal of the American Chemical Society. 2010. Vol. 132. No. 44. pp. 15726-15733.
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RIS
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TY - JOUR
DO - 10.1021/ja106399h
UR - https://doi.org/10.1021/ja106399h
TI - Acyclic Chelate with Ideal Properties for 68Ga PET Imaging Agent Elaboration
T2 - Journal of the American Chemical Society
AU - Boros, Eszter
AU - Ferreira, Cara L.
AU - Cawthray, Jacqueline
AU - Price, E. W.
AU - Patrick, Brian N.
AU - Wester, Dennis W.
AU - Adam, Michael J.
AU - Orvig, Chris
PY - 2010
DA - 2010/10/19
PB - American Chemical Society (ACS)
SP - 15726-15733
IS - 44
VL - 132
PMID - 20958034
SN - 0002-7863
SN - 1520-5126
ER -
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BibTex (до 50 авторов)
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@article{2010_Boros,
author = {Eszter Boros and Cara L. Ferreira and Jacqueline Cawthray and E. W. Price and Brian N. Patrick and Dennis W. Wester and Michael J. Adam and Chris Orvig},
title = {Acyclic Chelate with Ideal Properties for 68Ga PET Imaging Agent Elaboration},
journal = {Journal of the American Chemical Society},
year = {2010},
volume = {132},
publisher = {American Chemical Society (ACS)},
month = {oct},
url = {https://doi.org/10.1021/ja106399h},
number = {44},
pages = {15726--15733},
doi = {10.1021/ja106399h}
}
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MLA
Скопировать
Boros, Eszter, et al. “Acyclic Chelate with Ideal Properties for 68Ga PET Imaging Agent Elaboration.” Journal of the American Chemical Society, vol. 132, no. 44, Oct. 2010, pp. 15726-15733. https://doi.org/10.1021/ja106399h.