Multivalent, High-Relaxivity MRI Contrast Agents Using Rigid Cysteine-Reactive Gadolinium Complexes
Тип публикации: Journal Article
Дата публикации: 2011-08-26
scimago Q1
wos Q1
БС1
SJR: 5.489
CiteScore: 24.4
Impact factor: 15.6
ISSN: 00027863, 15205126
PubMed ID:
21800868
General Chemistry
Catalysis
Biochemistry
Colloid and Surface Chemistry
Краткое описание
MRI contrast agents providing very high relaxivity values can be obtained through the attachment of multiple gadolinium(III) complexes to the interior surfaces of genome-free viral capsids. In previous studies, the contrast enhancement was predicted to depend on the rigidity of the linker attaching the MRI agents to the protein surface. To test this hypothesis, a new set of Gd-hydroxypyridonate based MRI agents was prepared and attached to genetically introduced cysteine residues through flexible and rigid linkers. Greater contrast enhancements were seen for MRI agents that were attached via rigid linkers, validating the design concept and outlining a path for future improvements of nanoscale MRI contrast agents.
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112
Всего цитирований:
112
Цитирований c 2025:
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(1.79%)
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ГОСТ |
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BibTex |
MLA
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ГОСТ
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Garimella P. D. et al. Multivalent, High-Relaxivity MRI Contrast Agents Using Rigid Cysteine-Reactive Gadolinium Complexes // Journal of the American Chemical Society. 2011. Vol. 133. No. 37. pp. 14704-14709.
ГОСТ со всеми авторами (до 50)
Скопировать
Garimella P. D., Datta A., Romanini D. W., Raymond K. N., Francis M. R. Multivalent, High-Relaxivity MRI Contrast Agents Using Rigid Cysteine-Reactive Gadolinium Complexes // Journal of the American Chemical Society. 2011. Vol. 133. No. 37. pp. 14704-14709.
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RIS
Скопировать
TY - JOUR
DO - 10.1021/ja204516p
UR - https://doi.org/10.1021/ja204516p
TI - Multivalent, High-Relaxivity MRI Contrast Agents Using Rigid Cysteine-Reactive Gadolinium Complexes
T2 - Journal of the American Chemical Society
AU - Garimella, Praveena D
AU - Datta, Ankona
AU - Romanini, Dante W
AU - Raymond, Kenneth N.
AU - Francis, Matthew R.
PY - 2011
DA - 2011/08/26
PB - American Chemical Society (ACS)
SP - 14704-14709
IS - 37
VL - 133
PMID - 21800868
SN - 0002-7863
SN - 1520-5126
ER -
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BibTex (до 50 авторов)
Скопировать
@article{2011_Garimella,
author = {Praveena D Garimella and Ankona Datta and Dante W Romanini and Kenneth N. Raymond and Matthew R. Francis},
title = {Multivalent, High-Relaxivity MRI Contrast Agents Using Rigid Cysteine-Reactive Gadolinium Complexes},
journal = {Journal of the American Chemical Society},
year = {2011},
volume = {133},
publisher = {American Chemical Society (ACS)},
month = {aug},
url = {https://doi.org/10.1021/ja204516p},
number = {37},
pages = {14704--14709},
doi = {10.1021/ja204516p}
}
Цитировать
MLA
Скопировать
Garimella, Praveena D., et al. “Multivalent, High-Relaxivity MRI Contrast Agents Using Rigid Cysteine-Reactive Gadolinium Complexes.” Journal of the American Chemical Society, vol. 133, no. 37, Aug. 2011, pp. 14704-14709. https://doi.org/10.1021/ja204516p.