Tryptophan Switch for a Photoactivated Platinum Anticancer Complex
2
Photobiology Unit, Department
of Dermatology, Ninewells Hospital, Dundee
DD1 9SY, U.K.
|
3
UNIVERSITY OF WARWICK
|
Publication type: Journal Article
Publication date: 2012-09-25
scimago Q1
wos Q1
SJR: 5.554
CiteScore: 22.5
Impact factor: 15.6
ISSN: 00027863, 15205126
PubMed ID:
22991971
General Chemistry
Catalysis
Biochemistry
Colloid and Surface Chemistry
Abstract
The octahedral Pt(IV) complex trans,trans,trans-[Pt(N(3))(2)(OH)(2)(py)(2)] (1) is potently cytotoxic to cancer cells when irradiated with visible (blue) light. We show that the acute photocytotoxicity can be switched off by low doses (500 μM) of the amino acid l-tryptophan. EPR and NMR spectroscopic experiments using spin traps show that l-Trp quenches the formation of azidyl radicals, probably by acting as an electron donor. l-Trp is well-known as a mediator of electron transfer between distant electron acceptor/donor centers in proteins, and such properties may make the free amino acid clinically useful for controlling the activity of photochemotherapeutic azido Pt(IV) drugs. Since previous work has demonstrated the ability of photoactivated 1 to platinate DNA, this suggests that the high potency of such photoactive platinum complexes is related to their dual attack on cancer cells by radicals and Pt(II) photoproducts.
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116
Total citations:
116
Citations from 2025:
5
(4.31%)
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GOST
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Butler J. R. et al. Tryptophan Switch for a Photoactivated Platinum Anticancer Complex // Journal of the American Chemical Society. 2012. Vol. 134. No. 40. pp. 16508-16511.
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Butler J. R., Woods J. A., Farrer N. J., Sadler P. J. Tryptophan Switch for a Photoactivated Platinum Anticancer Complex // Journal of the American Chemical Society. 2012. Vol. 134. No. 40. pp. 16508-16511.
Cite this
RIS
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TY - JOUR
DO - 10.1021/ja3074159
UR - https://doi.org/10.1021/ja3074159
TI - Tryptophan Switch for a Photoactivated Platinum Anticancer Complex
T2 - Journal of the American Chemical Society
AU - Butler, Jennifer R.
AU - Woods, Julie A
AU - Farrer, Nicola J.
AU - Sadler, Peter J.
PY - 2012
DA - 2012/09/25
PB - American Chemical Society (ACS)
SP - 16508-16511
IS - 40
VL - 134
PMID - 22991971
SN - 0002-7863
SN - 1520-5126
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2012_Butler,
author = {Jennifer R. Butler and Julie A Woods and Nicola J. Farrer and Peter J. Sadler},
title = {Tryptophan Switch for a Photoactivated Platinum Anticancer Complex},
journal = {Journal of the American Chemical Society},
year = {2012},
volume = {134},
publisher = {American Chemical Society (ACS)},
month = {sep},
url = {https://doi.org/10.1021/ja3074159},
number = {40},
pages = {16508--16511},
doi = {10.1021/ja3074159}
}
Cite this
MLA
Copy
Butler, Jennifer R., et al. “Tryptophan Switch for a Photoactivated Platinum Anticancer Complex.” Journal of the American Chemical Society, vol. 134, no. 40, Sep. 2012, pp. 16508-16511. https://doi.org/10.1021/ja3074159.