Multiplexed Screening of Cellular Uptake of Gold Nanoparticles Using Laser Desorption/Ionization Mass Spectrometry
Тип публикации: Journal Article
Дата публикации: 2008-10-01
SCImago Q1
Tоп 10% SCImago
WOS Q1
БС1
SJR: 5.491
CiteScore: 22
Impact factor: 16.6
ISSN: 00027863, 15205126
PubMed ID:
18826222
General Chemistry
Catalysis
Biochemistry
Colloid and Surface Chemistry
Краткое описание
Gold nanoparticles (AuNPs) are highly promising candidates as drug delivery agents into cells of interest. We describe for the first time the multiplexed analysis of nanoparticle uptake by cells using mass spectrometry. We demonstrate that the cellular uptake of functionalized gold nanoparticles with cationic or neutral surface ligands can be readily determined using laser desorption/ionization mass spectrometry of cell lysates. The surface ligands have "mass barcodes" that allow different nanoparticles to be simultaneously identified and quantified at levels as low as 30 pmol. Using this method, we find that subtle changes to AuNP surface functionalities can lead to measurable changes in cellular uptake propensities.
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Метрики
126
Всего цитирований:
126
Цитирований c 2025:
5
(3.96%)
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ГОСТ |
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BibTex |
MLA
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ГОСТ
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Zhu Z. J. et al. Multiplexed Screening of Cellular Uptake of Gold Nanoparticles Using Laser Desorption/Ionization Mass Spectrometry // Journal of the American Chemical Society. 2008. Vol. 130. No. 43. pp. 14139-14143.
ГОСТ со всеми авторами (до 50)
Скопировать
Zhu Z. J., Ghosh P. S., Miranda O. R., Vachet R. W., Rotello V. Multiplexed Screening of Cellular Uptake of Gold Nanoparticles Using Laser Desorption/Ionization Mass Spectrometry // Journal of the American Chemical Society. 2008. Vol. 130. No. 43. pp. 14139-14143.
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RIS
Скопировать
TY - JOUR
DO - 10.1021/ja805392f
UR - https://doi.org/10.1021/ja805392f
TI - Multiplexed Screening of Cellular Uptake of Gold Nanoparticles Using Laser Desorption/Ionization Mass Spectrometry
T2 - Journal of the American Chemical Society
AU - Zhu, Zheng Jiang
AU - Ghosh, Partha S.
AU - Miranda, Oscar R
AU - Vachet, Richard W.
AU - Rotello, Vincent
PY - 2008
DA - 2008/10/01
PB - American Chemical Society (ACS)
SP - 14139-14143
IS - 43
VL - 130
PMID - 18826222
SN - 0002-7863
SN - 1520-5126
ER -
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BibTex (до 50 авторов)
Скопировать
@article{2008_Zhu,
author = {Zheng Jiang Zhu and Partha S. Ghosh and Oscar R Miranda and Richard W. Vachet and Vincent Rotello},
title = {Multiplexed Screening of Cellular Uptake of Gold Nanoparticles Using Laser Desorption/Ionization Mass Spectrometry},
journal = {Journal of the American Chemical Society},
year = {2008},
volume = {130},
publisher = {American Chemical Society (ACS)},
month = {oct},
url = {https://doi.org/10.1021/ja805392f},
number = {43},
pages = {14139--14143},
doi = {10.1021/ja805392f}
}
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MLA
Скопировать
Zhu, Zheng Jiang, et al. “Multiplexed Screening of Cellular Uptake of Gold Nanoparticles Using Laser Desorption/Ionization Mass Spectrometry.” Journal of the American Chemical Society, vol. 130, no. 43, Oct. 2008, pp. 14139-14143. https://doi.org/10.1021/ja805392f.
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