Structural Basis for Catalytic Activation of Thiocyanate Hydrolase Involving Metal-Ligated Cysteine Modification
Takatoshi Arakawa
1
,
Yoshiaki Kawano
1
,
Yoko Katayama
1
,
HIROSHI NAKAYAMA
1
,
NAOSHI DOHMAE
1
,
Masafumi Yohda
1
,
Masafumi Odaka
1
Publication type: Journal Article
Publication date: 2009-09-28
scimago Q1
wos Q1
SJR: 5.554
CiteScore: 22.5
Impact factor: 15.6
ISSN: 00027863, 15205126
PubMed ID:
19785438
General Chemistry
Catalysis
Biochemistry
Colloid and Surface Chemistry
Abstract
Thiocyanate hydrolase (SCNase) is a member of a family of nitrile hydratase proteins, each of which contains a unique noncorrin cobalt center with two post-translationally modified cysteine ligands, cysteine-sulfenic acid or -sulfenate (Cys-SO(H)), and cysteine-sulfininate (Cys-SO(2)(-)), respectively. We have found that a partially matured recombinant SCNase was activated during storage. The crystal structures of SCNase before and after storage demonstrated that Cys-SO(2)(-) modification of gammaCys131 proceeded to completion prior to storage, while Cys-SO(H) modification of gammaCys133 occurred during storage. SCNase activity was suppressed when gammaCys133 was further oxidized to Cys-SO(2)(-). The correlation between the catalytic activity and the extent of the gammaCys133 modification indicates that the cysteine sulfenic acid modification of gammaCys133 is of primary importance in determining the activity of SCNase.
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41
Total citations:
41
Citations from 2024:
6
(14.64%)
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GOST
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Arakawa T. et al. Structural Basis for Catalytic Activation of Thiocyanate Hydrolase Involving Metal-Ligated Cysteine Modification // Journal of the American Chemical Society. 2009. Vol. 131. No. 41. pp. 14838-14843.
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Arakawa T., Kawano Y., Katayama Y., NAKAYAMA H., DOHMAE N., Yohda M., Odaka M. Structural Basis for Catalytic Activation of Thiocyanate Hydrolase Involving Metal-Ligated Cysteine Modification // Journal of the American Chemical Society. 2009. Vol. 131. No. 41. pp. 14838-14843.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1021/ja903979s
UR - https://doi.org/10.1021/ja903979s
TI - Structural Basis for Catalytic Activation of Thiocyanate Hydrolase Involving Metal-Ligated Cysteine Modification
T2 - Journal of the American Chemical Society
AU - Arakawa, Takatoshi
AU - Kawano, Yoshiaki
AU - Katayama, Yoko
AU - NAKAYAMA, HIROSHI
AU - DOHMAE, NAOSHI
AU - Yohda, Masafumi
AU - Odaka, Masafumi
PY - 2009
DA - 2009/09/28
PB - American Chemical Society (ACS)
SP - 14838-14843
IS - 41
VL - 131
PMID - 19785438
SN - 0002-7863
SN - 1520-5126
ER -
Cite this
BibTex (up to 50 authors)
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@article{2009_Arakawa,
author = {Takatoshi Arakawa and Yoshiaki Kawano and Yoko Katayama and HIROSHI NAKAYAMA and NAOSHI DOHMAE and Masafumi Yohda and Masafumi Odaka},
title = {Structural Basis for Catalytic Activation of Thiocyanate Hydrolase Involving Metal-Ligated Cysteine Modification},
journal = {Journal of the American Chemical Society},
year = {2009},
volume = {131},
publisher = {American Chemical Society (ACS)},
month = {sep},
url = {https://doi.org/10.1021/ja903979s},
number = {41},
pages = {14838--14843},
doi = {10.1021/ja903979s}
}
Cite this
MLA
Copy
Arakawa, Takatoshi, et al. “Structural Basis for Catalytic Activation of Thiocyanate Hydrolase Involving Metal-Ligated Cysteine Modification.” Journal of the American Chemical Society, vol. 131, no. 41, Sep. 2009, pp. 14838-14843. https://doi.org/10.1021/ja903979s.