Enzymatic Ligation Reactions of DNA “Words” on Surfaces for DNA Computing
Publication type: Journal Article
Publication date: 1998-09-25
scimago Q1
wos Q1
SJR: 5.554
CiteScore: 22.5
Impact factor: 15.6
ISSN: 00027863, 15205126
General Chemistry
Catalysis
Biochemistry
Colloid and Surface Chemistry
Abstract
The enzymatic manipulation of sets of short, 16-base oligonucleotides, or DNA “words”, is demonstrated with applications toward DNA computing on surfaces. The enzyme T4 DNA ligase is used to ligate (join) DNA words on a chemically modified gold thin film. The efficiency of this surface ligation reaction is 80%, as determined by removal of the ligated molecules from the surface followed by gel electrophoresis. This surface ligation reaction is used in two new operations for DNA computing on surfaces. In a “Surface Word Append” operation, the complexity and information density of DNA word strands attached to gold surfaces are increased by appending additional words onto these word strands. The ligation reaction is also utilized as part of a “Two-Word Mark and Destroy” operation in which singly marked two-word DNA strands are selectively removed from the surface in the presence of doubly marked two-word strands. These new operations are essential for manipulation of the large combinatorial sets of linked DNA...
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GOST
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Frutos A. G., Smith L. V., CORN R. C. Enzymatic Ligation Reactions of DNA “Words” on Surfaces for DNA Computing // Journal of the American Chemical Society. 1998. Vol. 120. No. 40. pp. 10277-10282.
GOST all authors (up to 50)
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Frutos A. G., Smith L. V., CORN R. C. Enzymatic Ligation Reactions of DNA “Words” on Surfaces for DNA Computing // Journal of the American Chemical Society. 1998. Vol. 120. No. 40. pp. 10277-10282.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1021/ja982030w
UR - https://doi.org/10.1021/ja982030w
TI - Enzymatic Ligation Reactions of DNA “Words” on Surfaces for DNA Computing
T2 - Journal of the American Chemical Society
AU - Frutos, Anthony G.
AU - Smith, Lloyd V.
AU - CORN, ROBERT C.
PY - 1998
DA - 1998/09/25
PB - American Chemical Society (ACS)
SP - 10277-10282
IS - 40
VL - 120
SN - 0002-7863
SN - 1520-5126
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{1998_Frutos,
author = {Anthony G. Frutos and Lloyd V. Smith and ROBERT C. CORN},
title = {Enzymatic Ligation Reactions of DNA “Words” on Surfaces for DNA Computing},
journal = {Journal of the American Chemical Society},
year = {1998},
volume = {120},
publisher = {American Chemical Society (ACS)},
month = {sep},
url = {https://doi.org/10.1021/ja982030w},
number = {40},
pages = {10277--10282},
doi = {10.1021/ja982030w}
}
Cite this
MLA
Copy
Frutos, Anthony G., et al. “Enzymatic Ligation Reactions of DNA “Words” on Surfaces for DNA Computing.” Journal of the American Chemical Society, vol. 120, no. 40, Sep. 1998, pp. 10277-10282. https://doi.org/10.1021/ja982030w.