Recent Advances and Future Developments in the Preparation of Polypeptides via N-Carboxyanhydride (NCA) Ring-Opening Polymerization
Publication type: Journal Article
Publication date: 2024-08-22
scimago Q1
wos Q1
SJR: 5.554
CiteScore: 22.5
Impact factor: 15.6
ISSN: 00027863, 15205126
PubMed ID:
39172171
Abstract
Polypeptides have the same or similar backbone structures as proteins and peptides, rendering them as suitable and important biomaterials. Amino acid N-carboxyanhydrides (NCA) ring-opening polymerization has been the most efficient strategy for polypeptide preparation, with continuous advance in the design of initiators, catalysts and reaction conditions. This Perspective first summarizes the recent progress of NCA synthesis and purification. Subsequently, we focus on various initiators for NCA polymerization, catalysts for accelerating polymerization or enhancing the controllability of polymerization, and recent advances in the reaction approach of NCA polymerization. Finally, we discuss future research directions and open challenges.
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56
Total citations:
56
Citations from 2025:
50
(89.29%)
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GOST
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Wu Y. et al. Recent Advances and Future Developments in the Preparation of Polypeptides via N-Carboxyanhydride (NCA) Ring-Opening Polymerization // Journal of the American Chemical Society. 2024. Vol. 146. No. 35. pp. 24189-24208.
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Wu Y., Chen Kang, Wang J., Chen M., Dai W., Liu R. Recent Advances and Future Developments in the Preparation of Polypeptides via N-Carboxyanhydride (NCA) Ring-Opening Polymerization // Journal of the American Chemical Society. 2024. Vol. 146. No. 35. pp. 24189-24208.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1021/jacs.4c05382
UR - https://pubs.acs.org/doi/10.1021/jacs.4c05382
TI - Recent Advances and Future Developments in the Preparation of Polypeptides via N-Carboxyanhydride (NCA) Ring-Opening Polymerization
T2 - Journal of the American Chemical Society
AU - Wu, Yueming
AU - Chen Kang
AU - Wang, Jiangzhou
AU - Chen, Minzhang
AU - Dai, Wenhui
AU - Liu, Runhui
PY - 2024
DA - 2024/08/22
PB - American Chemical Society (ACS)
SP - 24189-24208
IS - 35
VL - 146
PMID - 39172171
SN - 0002-7863
SN - 1520-5126
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2024_Wu,
author = {Yueming Wu and Chen Kang and Jiangzhou Wang and Minzhang Chen and Wenhui Dai and Runhui Liu},
title = {Recent Advances and Future Developments in the Preparation of Polypeptides via N-Carboxyanhydride (NCA) Ring-Opening Polymerization},
journal = {Journal of the American Chemical Society},
year = {2024},
volume = {146},
publisher = {American Chemical Society (ACS)},
month = {aug},
url = {https://pubs.acs.org/doi/10.1021/jacs.4c05382},
number = {35},
pages = {24189--24208},
doi = {10.1021/jacs.4c05382}
}
Cite this
MLA
Copy
Wu, Yueming, et al. “Recent Advances and Future Developments in the Preparation of Polypeptides via N-Carboxyanhydride (NCA) Ring-Opening Polymerization.” Journal of the American Chemical Society, vol. 146, no. 35, Aug. 2024, pp. 24189-24208. https://pubs.acs.org/doi/10.1021/jacs.4c05382.
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