Journal of the American Chemical Society, volume 139, issue 40, pages 13985-13988
Prevalent Sequences in the Human Genome Can Form Mini i-Motif Structures at Physiological pH
Bartomeu Mir
1, 2
,
Israel Serrano
3
,
Diana Buitrago
4
,
M. Orozco
4, 5
,
Nuria Sánchez
1, 2
,
Carlos Gonzalez
2, 3
2
BIOESTRAN associated unit UB-CSIC, 08028 Barcelona, Spain
|
Publication type: Journal Article
Publication date: 2017-09-27
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 15
ISSN: 00027863, 15205126
General Chemistry
Catalysis
Biochemistry
Colloid and Surface Chemistry
Abstract
We report here the solution structure of several repetitive DNA sequences containing d(TCGTTCCGT) and related repeats. At physiological pH, these sequences fold into i-motif like quadruplexes in which every two repeats a globular structure is stabilized by two hemiprotonated C:C+ base pairs, flanked by two minor groove tetrads resulting from the association of G:C or G:T base pairs. The interaction between the minor groove tetrads and the nearby C:C+ base pairs affords a strong stabilization, which results in effective pHT values above 7.5. Longer sequences with more than two repeats are able to fold in tandem, forming a rosary bead-like structure. Bioinformatics analysis shows that these sequences are prevalent in the human genome, and are present in development-related genes.
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Mir B. et al. Prevalent Sequences in the Human Genome Can Form Mini i-Motif Structures at Physiological pH // Journal of the American Chemical Society. 2017. Vol. 139. No. 40. pp. 13985-13988.
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Mir B., Serrano I., Buitrago D., Orozco M., Sánchez N., Gonzalez C. Prevalent Sequences in the Human Genome Can Form Mini i-Motif Structures at Physiological pH // Journal of the American Chemical Society. 2017. Vol. 139. No. 40. pp. 13985-13988.
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TY - JOUR
DO - 10.1021/jacs.7b07383
UR - https://doi.org/10.1021/jacs.7b07383
TI - Prevalent Sequences in the Human Genome Can Form Mini i-Motif Structures at Physiological pH
T2 - Journal of the American Chemical Society
AU - Mir, Bartomeu
AU - Serrano, Israel
AU - Orozco, M.
AU - Gonzalez, Carlos
AU - Buitrago, Diana
AU - Sánchez, Nuria
PY - 2017
DA - 2017/09/27
PB - American Chemical Society (ACS)
SP - 13985-13988
IS - 40
VL - 139
SN - 0002-7863
SN - 1520-5126
ER -
Cite this
BibTex
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@article{2017_Mir,
author = {Bartomeu Mir and Israel Serrano and M. Orozco and Carlos Gonzalez and Diana Buitrago and Nuria Sánchez},
title = {Prevalent Sequences in the Human Genome Can Form Mini i-Motif Structures at Physiological pH},
journal = {Journal of the American Chemical Society},
year = {2017},
volume = {139},
publisher = {American Chemical Society (ACS)},
month = {sep},
url = {https://doi.org/10.1021/jacs.7b07383},
number = {40},
pages = {13985--13988},
doi = {10.1021/jacs.7b07383}
}
Cite this
MLA
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Mir, Bartomeu, et al. “Prevalent Sequences in the Human Genome Can Form Mini i-Motif Structures at Physiological pH.” Journal of the American Chemical Society, vol. 139, no. 40, Sep. 2017, pp. 13985-13988. https://doi.org/10.1021/jacs.7b07383.