Direct Carbon Isotope Exchange through Decarboxylative Carboxylation
Cian Kingston
1
,
Michael A Wallace
2
,
Alban Allentoff
2
,
Jason Chen
3
,
Sharon X Gong
2
,
Samuel Bonacorsi
2
,
Publication type: Journal Article
Publication date: 2019-01-03
scimago Q1
wos Q1
SJR: 5.554
CiteScore: 22.5
Impact factor: 15.6
ISSN: 00027863, 15205126
PubMed ID:
30605319
General Chemistry
Catalysis
Biochemistry
Colloid and Surface Chemistry
Abstract
A two-step degradation-reconstruction approach to the carbon-14 radiolabeling of alkyl carboxylic acids is presented. Simple activation via redox-active ester formation was followed by nickel-mediated decarboxylative carboxylation to afford a range of complex compounds with ample isotopic incorporations for drug metabolism and pharmacokinetic studies. The practicality and operational simplicity of the protocol were demonstrated by its use in an industrial carbon-14 radiolabeling setting.
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Metrics
77
Total citations:
77
Citations from 2024:
19
(24%)
Cite this
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RIS |
BibTex |
MLA
Cite this
GOST
Copy
Kingston C. et al. Direct Carbon Isotope Exchange through Decarboxylative Carboxylation // Journal of the American Chemical Society. 2019. Vol. 141. No. 2. pp. 774-779.
GOST all authors (up to 50)
Copy
Kingston C., Wallace M. A., Allentoff A., Degruyter J. N., Chen J., Gong S. X., Bonacorsi S., Baran P. S. Direct Carbon Isotope Exchange through Decarboxylative Carboxylation // Journal of the American Chemical Society. 2019. Vol. 141. No. 2. pp. 774-779.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1021/jacs.8b12035
UR - https://doi.org/10.1021/jacs.8b12035
TI - Direct Carbon Isotope Exchange through Decarboxylative Carboxylation
T2 - Journal of the American Chemical Society
AU - Kingston, Cian
AU - Wallace, Michael A
AU - Allentoff, Alban
AU - Degruyter, Justine N
AU - Chen, Jason
AU - Gong, Sharon X
AU - Bonacorsi, Samuel
AU - Baran, Phil S
PY - 2019
DA - 2019/01/03
PB - American Chemical Society (ACS)
SP - 774-779
IS - 2
VL - 141
PMID - 30605319
SN - 0002-7863
SN - 1520-5126
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2019_Kingston,
author = {Cian Kingston and Michael A Wallace and Alban Allentoff and Justine N Degruyter and Jason Chen and Sharon X Gong and Samuel Bonacorsi and Phil S Baran},
title = {Direct Carbon Isotope Exchange through Decarboxylative Carboxylation},
journal = {Journal of the American Chemical Society},
year = {2019},
volume = {141},
publisher = {American Chemical Society (ACS)},
month = {jan},
url = {https://doi.org/10.1021/jacs.8b12035},
number = {2},
pages = {774--779},
doi = {10.1021/jacs.8b12035}
}
Cite this
MLA
Copy
Kingston, Cian, et al. “Direct Carbon Isotope Exchange through Decarboxylative Carboxylation.” Journal of the American Chemical Society, vol. 141, no. 2, Jan. 2019, pp. 774-779. https://doi.org/10.1021/jacs.8b12035.
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