Antineoplastic Agents. 291. Isolation and Synthesis of Combretastatins A-4, A-5, and A-6
George W. Pettit
1
,
Sheo K. Singh
2
,
Michael R Boyd
3, 4
,
Ernest Hamel
3, 4
,
Robin K. Pettit
5
,
Jean M. Schmidt
2
,
FIONA HOGAN
2
4
NATIONAL INSTITUTES OF HEALTH
5
Biodesign Institute
Publication type: Journal Article
Publication date: 1995-05-01
scimago Q1
wos Q1
SJR: 1.801
CiteScore: 11.5
Impact factor: 6.8
ISSN: 00222623, 15204804
PubMed ID:
7752190
Drug Discovery
Molecular Medicine
Abstract
The antineoplastic constituents of Combretum caffrum (Eckl. and Zeyh) Kuntze (Combretaceae family), a species indigenous to South Africa, have been investigated. Subsequently we isolated a series of closely related bibenzyls, stilbenes, and phenanthrenes from C. caffrum. Some of the stilbenes proved to be potent antimitotic agents which inhibited both tubulin polymerization and the binding of colchicine to tubulin. Combretastatin A-4 has been shown to be the most potent cancer cell growth inhibitor of the series. Presently this cis-stilbene is the most effective inhibitor of colchicine binding to tubulin and the simplest natural product yet described with such potent antitubulin effects. Combretastatin A-4, A-5, and A-6 were also found to inhibit growth of Neisseria gonorrhoeae. Details of the isolation and syntheses of combretastatins A-4 (2a), A-5 (2c), and A-6 (3a) have been described.
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350
Total citations:
350
Citations from 2024:
27
(7.71%)
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GOST
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Pettit G. et al. Antineoplastic Agents. 291. Isolation and Synthesis of Combretastatins A-4, A-5, and A-6 // Journal of Medicinal Chemistry. 1995. Vol. 38. No. 10. pp. 1666-1672.
GOST all authors (up to 50)
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Pettit G., Singh S. K., Boyd M. R., Hamel E., Pettit R. K., Schmidt J. M., HOGAN F. Antineoplastic Agents. 291. Isolation and Synthesis of Combretastatins A-4, A-5, and A-6 // Journal of Medicinal Chemistry. 1995. Vol. 38. No. 10. pp. 1666-1672.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1021/jm00010a011
UR - https://doi.org/10.1021/jm00010a011
TI - Antineoplastic Agents. 291. Isolation and Synthesis of Combretastatins A-4, A-5, and A-6
T2 - Journal of Medicinal Chemistry
AU - Pettit, George W.
AU - Singh, Sheo K.
AU - Boyd, Michael R
AU - Hamel, Ernest
AU - Pettit, Robin K.
AU - Schmidt, Jean M.
AU - HOGAN, FIONA
PY - 1995
DA - 1995/05/01
PB - American Chemical Society (ACS)
SP - 1666-1672
IS - 10
VL - 38
PMID - 7752190
SN - 0022-2623
SN - 1520-4804
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{1995_Pettit,
author = {George W. Pettit and Sheo K. Singh and Michael R Boyd and Ernest Hamel and Robin K. Pettit and Jean M. Schmidt and FIONA HOGAN},
title = {Antineoplastic Agents. 291. Isolation and Synthesis of Combretastatins A-4, A-5, and A-6},
journal = {Journal of Medicinal Chemistry},
year = {1995},
volume = {38},
publisher = {American Chemical Society (ACS)},
month = {may},
url = {https://doi.org/10.1021/jm00010a011},
number = {10},
pages = {1666--1672},
doi = {10.1021/jm00010a011}
}
Cite this
MLA
Copy
Pettit, George W., et al. “Antineoplastic Agents. 291. Isolation and Synthesis of Combretastatins A-4, A-5, and A-6.” Journal of Medicinal Chemistry, vol. 38, no. 10, May. 1995, pp. 1666-1672. https://doi.org/10.1021/jm00010a011.