Polyamine analogues with antitumor activity.
Тип публикации: Journal Article
Дата публикации: 1990-05-01
scimago Q1
wos Q1
БС1
SJR: 1.801
CiteScore: 11.5
Impact factor: 6.8
ISSN: 00222623, 15204804
PubMed ID:
2329556
Drug Discovery
Molecular Medicine
Краткое описание
A series of tetraamines derived from 1,8-diaminooctane was prepared and tested as antitumor agents. The reaction of 1,8-diaminooctane with acrylonitrile gave N,N'-bis(cyanoethyl)-1,8-diaminooctane, which was reduced to tetraamine 20. Alkylation of the terminal nitrogen atoms of the tetra-Boc derivative of this compound by methyl or ethyl halide followed by removal of the Boc groups gave the bis(alkyl)polyamines 26a and 26b, respectively. These three compounds exhibit promising antitumor activity in the mouse L1210 leukemia model. Coadministration of a polyamine oxidase inhibitor potentiated the antitumor activity.
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ГОСТ
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Edwards M. L. et al. Polyamine analogues with antitumor activity. // Journal of Medicinal Chemistry. 1990. Vol. 33. No. 5. pp. 1369-1375.
ГОСТ со всеми авторами (до 50)
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Edwards M. L. Polyamine analogues with antitumor activity. // Journal of Medicinal Chemistry. 1990. Vol. 33. No. 5. pp. 1369-1375.
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RIS
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TY - JOUR
DO - 10.1021/jm00167a014
UR - https://doi.org/10.1021/jm00167a014
TI - Polyamine analogues with antitumor activity.
T2 - Journal of Medicinal Chemistry
AU - Edwards, Michael L.
PY - 1990
DA - 1990/05/01
PB - American Chemical Society (ACS)
SP - 1369-1375
IS - 5
VL - 33
PMID - 2329556
SN - 0022-2623
SN - 1520-4804
ER -
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BibTex (до 50 авторов)
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@article{1990_Edwards,
author = {Michael L. Edwards},
title = {Polyamine analogues with antitumor activity.},
journal = {Journal of Medicinal Chemistry},
year = {1990},
volume = {33},
publisher = {American Chemical Society (ACS)},
month = {may},
url = {https://doi.org/10.1021/jm00167a014},
number = {5},
pages = {1369--1375},
doi = {10.1021/jm00167a014}
}
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MLA
Скопировать
Edwards, Michael L., et al. “Polyamine analogues with antitumor activity..” Journal of Medicinal Chemistry, vol. 33, no. 5, May. 1990, pp. 1369-1375. https://doi.org/10.1021/jm00167a014.