Structure and antitumor activity relation of 2-arylidene-4-cyclopentene-1,3-diones and 2-arylideneindan-1,3-diones
Тип публикации: Journal Article
Дата публикации: 1976-03-01
SCImago Q1
Tоп 10% SCImago
WOS Q1
БС1
SJR: 1.726
CiteScore: 11.1
Impact factor: 7.3
ISSN: 00222623, 15204804
PubMed ID:
1255669
Drug Discovery
Molecular Medicine
Краткое описание
A series of 2-arylidene-4-cyclopentene-1,3-diones and 2-arylideneindan-1,3-diones, as well as mono- and bis(arylidene substituted)cycloalkanones, was synthesized and examined for antitumor activity against ascites sarcoma-180. All the 2-arylidene-4-cyclopentene-1,3-diones and one arylideneindan-1,3-dione (where the arylidene group was either a hydroxybenzylidene or substituted hydroxybenzylidene) exhibited a high degree of activity. Among both types of 1,3-diones and 3-methoxy-4-hydroxybenzylidene derivatives were found to possess the greatest potency, while all the mono- and bis(arylidene)cycloalkanones were found to be inactive.
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ГОСТ
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Inayama S. et al. Structure and antitumor activity relation of 2-arylidene-4-cyclopentene-1,3-diones and 2-arylideneindan-1,3-diones // Journal of Medicinal Chemistry. 1976. Vol. 19. No. 3. pp. 433-436.
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Inayama S., Mamoto K., Shibata T., HIROSE T. Structure and antitumor activity relation of 2-arylidene-4-cyclopentene-1,3-diones and 2-arylideneindan-1,3-diones // Journal of Medicinal Chemistry. 1976. Vol. 19. No. 3. pp. 433-436.
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TY - JOUR
DO - 10.1021/jm00225a022
UR - https://doi.org/10.1021/jm00225a022
TI - Structure and antitumor activity relation of 2-arylidene-4-cyclopentene-1,3-diones and 2-arylideneindan-1,3-diones
T2 - Journal of Medicinal Chemistry
AU - Inayama, Seiichi
AU - Mamoto, Katsuhiro
AU - Shibata, Tetsuichi
AU - HIROSE, TADAAKI
PY - 1976
DA - 1976/03/01
PB - American Chemical Society (ACS)
SP - 433-436
IS - 3
VL - 19
PMID - 1255669
SN - 0022-2623
SN - 1520-4804
ER -
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BibTex (до 50 авторов)
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@article{1976_Inayama,
author = {Seiichi Inayama and Katsuhiro Mamoto and Tetsuichi Shibata and TADAAKI HIROSE},
title = {Structure and antitumor activity relation of 2-arylidene-4-cyclopentene-1,3-diones and 2-arylideneindan-1,3-diones},
journal = {Journal of Medicinal Chemistry},
year = {1976},
volume = {19},
publisher = {American Chemical Society (ACS)},
month = {mar},
url = {https://doi.org/10.1021/jm00225a022},
number = {3},
pages = {433--436},
doi = {10.1021/jm00225a022}
}
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MLA
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Inayama, Seiichi, et al. “Structure and antitumor activity relation of 2-arylidene-4-cyclopentene-1,3-diones and 2-arylideneindan-1,3-diones.” Journal of Medicinal Chemistry, vol. 19, no. 3, Mar. 1976, pp. 433-436. https://doi.org/10.1021/jm00225a022.
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