Design, synthesis, and biological evaluation of fluoroneplanocin A as the novel mechanism-based inhibitor of S-adenosylhomocysteine hydrolase.
Тип публикации: Journal Article
Дата публикации: 2002-12-11
scimago Q1
wos Q1
БС1
SJR: 1.801
CiteScore: 11.5
Impact factor: 6.8
ISSN: 00222623, 15204804
PubMed ID:
12519056
Drug Discovery
Molecular Medicine
Краткое описание
Fluoroneplanocin A (12) was designed as a novel mechanism-based inhibitor of S-adenosylhomocysteine hydrolase (SAH) and efficiently synthesized via an electrophilic vinyl fluorination reaction (n-BuLi, N-fluorobenzenesulfonimide at -78 degrees C). Fluoroneplanocin A exhibited 2-fold more potent SAH inhibitory activity than the parent neplanocin A. A new mechanism of irreversible inhibition discovered in this work might provide new alternatives in the design of a different class of antiviral agents operating via SAH inhibition.
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ГОСТ
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Jeong L. S. et al. Design, synthesis, and biological evaluation of fluoroneplanocin A as the novel mechanism-based inhibitor of S-adenosylhomocysteine hydrolase. // Journal of Medicinal Chemistry. 2002. Vol. 46. No. 2. pp. 201-203.
ГОСТ со всеми авторами (до 50)
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Jeong L. S., Yoo S. J., Lee K. M., Koo M. J., Jun Choi W., Kim H. O., Moon H. B., Lee M., Park J. G., Lee S. K., CHUN M. W. Design, synthesis, and biological evaluation of fluoroneplanocin A as the novel mechanism-based inhibitor of S-adenosylhomocysteine hydrolase. // Journal of Medicinal Chemistry. 2002. Vol. 46. No. 2. pp. 201-203.
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RIS
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TY - JOUR
DO - 10.1021/jm025557z
UR - https://doi.org/10.1021/jm025557z
TI - Design, synthesis, and biological evaluation of fluoroneplanocin A as the novel mechanism-based inhibitor of S-adenosylhomocysteine hydrolase.
T2 - Journal of Medicinal Chemistry
AU - Jeong, Lak Shin
AU - Yoo, Su Jeong
AU - Lee, Kang Man
AU - Koo, Mi Jeong
AU - Jun Choi, Won
AU - Kim, Hea Ok
AU - Moon, Hyung Bae
AU - Lee, Min-Young
AU - Park, Jae Gyu
AU - Lee, Sang Kook
AU - CHUN, MOON WOO
PY - 2002
DA - 2002/12/11
PB - American Chemical Society (ACS)
SP - 201-203
IS - 2
VL - 46
PMID - 12519056
SN - 0022-2623
SN - 1520-4804
ER -
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BibTex (до 50 авторов)
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@article{2002_Jeong,
author = {Lak Shin Jeong and Su Jeong Yoo and Kang Man Lee and Mi Jeong Koo and Won Jun Choi and Hea Ok Kim and Hyung Bae Moon and Min-Young Lee and Jae Gyu Park and Sang Kook Lee and MOON WOO CHUN},
title = {Design, synthesis, and biological evaluation of fluoroneplanocin A as the novel mechanism-based inhibitor of S-adenosylhomocysteine hydrolase.},
journal = {Journal of Medicinal Chemistry},
year = {2002},
volume = {46},
publisher = {American Chemical Society (ACS)},
month = {dec},
url = {https://doi.org/10.1021/jm025557z},
number = {2},
pages = {201--203},
doi = {10.1021/jm025557z}
}
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MLA
Скопировать
Jeong, Lak Shin, et al. “Design, synthesis, and biological evaluation of fluoroneplanocin A as the novel mechanism-based inhibitor of S-adenosylhomocysteine hydrolase..” Journal of Medicinal Chemistry, vol. 46, no. 2, Dec. 2002, pp. 201-203. https://doi.org/10.1021/jm025557z.