Biological mechanisms of action of novel C-10 non-acetal trioxane dimers in prostate cancer cell lines.
Тип публикации: Journal Article
Дата публикации: 2006-11-29
scimago Q1
wos Q1
БС1
SJR: 1.801
CiteScore: 11.5
Impact factor: 6.8
ISSN: 00222623, 15204804
PubMed ID:
17181166
Drug Discovery
Molecular Medicine
Краткое описание
The mechanisms of action of three C-10 non-acetal trioxane dimers (TDs) were examined in human (LNCaP) and mouse (TRAMP-C1A and -C2H) prostate cancer cell lines. 1 (AJM3/23), 2 (GHP-TM-III-07w), and 3 (GHP-KB-06) inhibited cell growth with 3 being the most potent in C1A (GI50 = 18.0 nM), C2H (GI50 = 17.0 nM), and LNCaP (GI50 = 17.9 nM) cells. In comparison to a standard cytotoxic agent such as doxorubicin (GI50 = 45.3 nM), 3 (GI50 = 17.9 nM) inhibited LNCaP cell growth more potently. TDs induced G0/G1 cell cycle arrest in LNCaP cells and decreased cells in the S phase. These changes correlated with modulation of G1 phase cell cycle proteins including decreased cyclin D1, cyclin E, and cdk2 and increased p21waf1 and p27Kip1. TDs also promoted apoptosis in LNCaP cells with increased expression of proapoptotic bax. These results demonstrate that TDs are potentially useful agents that warrant further preclinical development for treatment of prostate cancer.
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Alagbala A. A. et al. Biological mechanisms of action of novel C-10 non-acetal trioxane dimers in prostate cancer cell lines. // Journal of Medicinal Chemistry. 2006. Vol. 49. No. 26. pp. 7836-7842.
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Alagbala A. A., Mcriner A. J., Borstnik K., Labonte T., Chang W., Dangelo J. G., Posner G. H., Foster B. A. Biological mechanisms of action of novel C-10 non-acetal trioxane dimers in prostate cancer cell lines. // Journal of Medicinal Chemistry. 2006. Vol. 49. No. 26. pp. 7836-7842.
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TY - JOUR
DO - 10.1021/jm060803i
UR - https://doi.org/10.1021/jm060803i
TI - Biological mechanisms of action of novel C-10 non-acetal trioxane dimers in prostate cancer cell lines.
T2 - Journal of Medicinal Chemistry
AU - Alagbala, Adebusola A.
AU - Mcriner, Andrew J
AU - Borstnik, Kristina
AU - Labonte, Tanzina
AU - Chang, Wonsuk
AU - Dangelo, John G
AU - Posner, Gary H.
AU - Foster, Barbara A.
PY - 2006
DA - 2006/11/29
PB - American Chemical Society (ACS)
SP - 7836-7842
IS - 26
VL - 49
PMID - 17181166
SN - 0022-2623
SN - 1520-4804
ER -
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@article{2006_Alagbala,
author = {Adebusola A. Alagbala and Andrew J Mcriner and Kristina Borstnik and Tanzina Labonte and Wonsuk Chang and John G Dangelo and Gary H. Posner and Barbara A. Foster},
title = {Biological mechanisms of action of novel C-10 non-acetal trioxane dimers in prostate cancer cell lines.},
journal = {Journal of Medicinal Chemistry},
year = {2006},
volume = {49},
publisher = {American Chemical Society (ACS)},
month = {nov},
url = {https://doi.org/10.1021/jm060803i},
number = {26},
pages = {7836--7842},
doi = {10.1021/jm060803i}
}
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MLA
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Alagbala, Adebusola A., et al. “Biological mechanisms of action of novel C-10 non-acetal trioxane dimers in prostate cancer cell lines..” Journal of Medicinal Chemistry, vol. 49, no. 26, Nov. 2006, pp. 7836-7842. https://doi.org/10.1021/jm060803i.