Fluorocyclopentenyl-cytosine with Broad Spectrum and Potent Antitumor Activity
Тип публикации: Journal Article
Дата публикации: 2012-05-01
scimago Q1
wos Q1
БС1
SJR: 1.801
CiteScore: 11.5
Impact factor: 6.8
ISSN: 00222623, 15204804
PubMed ID:
22524616
Drug Discovery
Molecular Medicine
Краткое описание
On the basis of the potent biological activity of cyclopentenyl-pyrimidines, fluorocyclopentenyl-pyrimidines were designed and synthesized from D-ribose. Among these, the cytosine derivative 5a showed highly potent antigrowth effects in a broad range of tumor cell lines and very potent antitumor activity in a nude mouse tumor xenograft model implanted with A549 human lung cancer cells. However, its 2'-deoxycytidine derivative 5b did not show any antigrowth effects, indicating that 2'-hydroxyl group is essential for the biological activity.
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ГОСТ
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Choi W. et al. Fluorocyclopentenyl-cytosine with Broad Spectrum and Potent Antitumor Activity // Journal of Medicinal Chemistry. 2012. Vol. 55. No. 9. pp. 4521-4525.
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Choi W., Chung H., CHANDRA G., Alexander V., Zhao L., Lee H. W., Nayak A., Satu Majik M., Kim H. O., Kim J., Lee Y. B., Ahn C. H., Lee S. K., Jeong L. S. Fluorocyclopentenyl-cytosine with Broad Spectrum and Potent Antitumor Activity // Journal of Medicinal Chemistry. 2012. Vol. 55. No. 9. pp. 4521-4525.
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TY - JOUR
DO - 10.1021/jm3004009
UR - https://doi.org/10.1021/jm3004009
TI - Fluorocyclopentenyl-cytosine with Broad Spectrum and Potent Antitumor Activity
T2 - Journal of Medicinal Chemistry
AU - Choi, Won-Jun
AU - Chung, Hwa-Jin
AU - CHANDRA, GIRISH
AU - Alexander, Varughese
AU - Zhao, Long-xuan
AU - Lee, Hyuk Woo
AU - Nayak, Akshata
AU - Satu Majik, Mahesh
AU - Kim, Hea Ok
AU - Kim, Jin-Hee
AU - Lee, Young B
AU - Ahn, Chang H
AU - Lee, Sang Kook
AU - Jeong, Lak Shin
PY - 2012
DA - 2012/05/01
PB - American Chemical Society (ACS)
SP - 4521-4525
IS - 9
VL - 55
PMID - 22524616
SN - 0022-2623
SN - 1520-4804
ER -
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BibTex (до 50 авторов)
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@article{2012_Choi,
author = {Won-Jun Choi and Hwa-Jin Chung and GIRISH CHANDRA and Varughese Alexander and Long-xuan Zhao and Hyuk Woo Lee and Akshata Nayak and Mahesh Satu Majik and Hea Ok Kim and Jin-Hee Kim and Young B Lee and Chang H Ahn and Sang Kook Lee and Lak Shin Jeong},
title = {Fluorocyclopentenyl-cytosine with Broad Spectrum and Potent Antitumor Activity},
journal = {Journal of Medicinal Chemistry},
year = {2012},
volume = {55},
publisher = {American Chemical Society (ACS)},
month = {may},
url = {https://doi.org/10.1021/jm3004009},
number = {9},
pages = {4521--4525},
doi = {10.1021/jm3004009}
}
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MLA
Скопировать
Choi, Won-Jun, et al. “Fluorocyclopentenyl-cytosine with Broad Spectrum and Potent Antitumor Activity.” Journal of Medicinal Chemistry, vol. 55, no. 9, May. 2012, pp. 4521-4525. https://doi.org/10.1021/jm3004009.