An Anthraquinone Scaffold for Putative, Two-Face Bim BH3 α-Helix Mimic
Publication type: Journal Article
Publication date: 2012-11-30
scimago Q1
wos Q1
SJR: 1.801
CiteScore: 11.5
Impact factor: 6.8
ISSN: 00222623, 15204804
PubMed ID:
23167494
Drug Discovery
Molecular Medicine
Abstract
Bim BH3 peptide features an α-helix with hotspot residues on multiple faces. Compound 5 (6-bromo-2,3-dihydroxyanthracene-9,10-dione), which adopts a rigid-plan amphipathic conformation, was designed and evaluated as a scaffold to mimic two faces of Bim α-helix. It reproduced the functionalities of both D67 and I65 on two opposing helical sides. Moreover, it maintained the two-faced binding mode during further evolution. A putative BH3 α-helix mimic and nanomolar Bcl-2/Mcl-1 dual inhibitor, 6, was obtained based on the structure of 5.
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Metrics
28
Total citations:
28
Citations from 2024:
4
(14.29%)
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MLA
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GOST
Copy
Zhang Z. C. et al. An Anthraquinone Scaffold for Putative, Two-Face Bim BH3 α-Helix Mimic // Journal of Medicinal Chemistry. 2012. Vol. 55. No. 23. pp. 10735-10741.
GOST all authors (up to 50)
Copy
Zhang Z. C., Li X., Song T., Zhao Y., Feng Y. An Anthraquinone Scaffold for Putative, Two-Face Bim BH3 α-Helix Mimic // Journal of Medicinal Chemistry. 2012. Vol. 55. No. 23. pp. 10735-10741.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1021/jm301504b
UR - https://doi.org/10.1021/jm301504b
TI - An Anthraquinone Scaffold for Putative, Two-Face Bim BH3 α-Helix Mimic
T2 - Journal of Medicinal Chemistry
AU - Zhang, Zhi Chao
AU - Li, Xiangqian
AU - Song, Ting
AU - Zhao, Yan
AU - Feng, Yingang
PY - 2012
DA - 2012/11/30
PB - American Chemical Society (ACS)
SP - 10735-10741
IS - 23
VL - 55
PMID - 23167494
SN - 0022-2623
SN - 1520-4804
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2012_Zhang,
author = {Zhi Chao Zhang and Xiangqian Li and Ting Song and Yan Zhao and Yingang Feng},
title = {An Anthraquinone Scaffold for Putative, Two-Face Bim BH3 α-Helix Mimic},
journal = {Journal of Medicinal Chemistry},
year = {2012},
volume = {55},
publisher = {American Chemical Society (ACS)},
month = {nov},
url = {https://doi.org/10.1021/jm301504b},
number = {23},
pages = {10735--10741},
doi = {10.1021/jm301504b}
}
Cite this
MLA
Copy
Zhang, Zhi Chao, et al. “An Anthraquinone Scaffold for Putative, Two-Face Bim BH3 α-Helix Mimic.” Journal of Medicinal Chemistry, vol. 55, no. 23, Nov. 2012, pp. 10735-10741. https://doi.org/10.1021/jm301504b.