Journal of Medicinal Chemistry

, volume 56 , issue 4 , pages 1564-1572

Development of bacteriostatic DNA aptamers for salmonella.

Olga S. Kolovskaya ¹

Xiaoyan Wang ²

Mohamed Wehbe ²

Nadezhda M Titova ³

Maxim V. Berezovski ²

Hide authors affiliations Show authors affiliations: 3 affiliations

Research Institute of Molecular Medicine and Pathobiochemistry, Krasnoyarsk State Medical University, 1 Partizana Zheleznyaka str., Krasnoyarsk 660022, Russia. |

Department of Chemistry, University of Ottawa, 10 Marie Curie, Ottawa, Ontario K1N 6N5, Canada |

Department of Medical Biology, Siberian Federal University, 79 Svobodny, Krasnoyarsk 660041, Russia |

Publication type: Journal Article

Publication date: 2013-02-19

American Chemical Society (ACS)

Journal of Medicinal Chemistry

scimago Q1

wos Q1

SJR: 1.801

CiteScore: 11.5

Impact factor: 6.8

ISSN: 00222623, 15204804

DOI: 10.1021/jm301856j

Copy DOI

PubMed ID: 23387511

Drug Discovery

Molecular Medicine

Abstract

Salmonella is one of the most dangerous and common food-borne pathogens. The overuse of antibiotics for disease prevention has led to the development of multidrug resistant Salmonella. Now, more than ever, there is a need for new antimicrobial drugs to combat these resistant bacteria. Aptamers have grown in popularity since their discovery, and their properties make them attractive candidates for therapeutic use. In this work, we describe the selection of highly specific DNA aptamers to S. enteritidis and S. typhimurium. To evolve species-specific aptamers, twelve rounds of selection to live S. enteritidis and S. typhimurium were performed, alternating with a negative selection against a mixture of related pathogens. Studies have shown that synthetic pools combined from individual aptamers have the capacity to inhibit growth of S. enteritidis and S. typhimurium in bacterial cultures; this was the result of a decrease in their membrane potential.

Found

1 citation

Morozov Anatolii

PhD in Chemistry, lecturer

47 publications, 1 506 citations

h-index: 17

Skolkovo Institute of Science and Technology

Lithium-ion batteries

Solid state chemistry

1 citation

Morozov Evgeny

🥼

PhD in Physics and Mathematics

38 publications, 494 citations, 4 reviews

h-index: 11

Institute of Chemistry and Chemical Technology of the Siberian Branch of the Russian Academy of Sciences

Kirensky Institute of Physics of the Siberian Branch of the Russian Academy of Sciences

Federal Research Center "Krasnoyarsk Science Center" of the Siberian Branch of the Russian Academy of Sciences

Research interests

Polymer composites

Soft matter

1 citation

Davidova Anna

🤝

PhD in Chemistry

22 publications, 286 citations

h-index: 8

Institute of Chemical Biology and Fundamental Medicine of the Siberian Branch of the Russian Academy of Sciences

Research Institute of Clinical and Experimental Lymphology ICG of the Siberian Branch of the Russian Academy of Sciences

Research interests

Biosensors

Catalytic nucleic acids

Molecular biology

1 citation

Vorobyeva Mariya

🥼 🤝

PhD in Chemistry

50 publications, 628 citations

h-index: 12

Institute of Chemical Biology and Fundamental Medicine of the Siberian Branch of the Russian Academy of Sciences

Immune-inflammatory rheumatic diseases

Oligonucleotides

SELEX

Therapeutic aptamers

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Kolovskaya O. S. et al. Development of bacteriostatic DNA aptamers for salmonella. // Journal of Medicinal Chemistry. 2013. Vol. 56. No. 4. pp. 1564-1572.

GOST all authors (up to 50) Copy

Kolovskaya O. S., Wang X., Wehbe M., Titova N. M., Berezovski M. V. Development of bacteriostatic DNA aptamers for salmonella. // Journal of Medicinal Chemistry. 2013. Vol. 56. No. 4. pp. 1564-1572.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1021/jm301856j

UR - https://doi.org/10.1021/jm301856j

TI - Development of bacteriostatic DNA aptamers for salmonella.

T2 - Journal of Medicinal Chemistry

AU - Kolovskaya, Olga S.

AU - Wang, Xiaoyan

AU - Wehbe, Mohamed

AU - Titova, Nadezhda M

AU - Berezovski, Maxim V.

PY - 2013

DA - 2013/02/19

PB - American Chemical Society (ACS)

SP - 1564-1572

IS - 4

VL - 56

PMID - 23387511

SN - 0022-2623

SN - 1520-4804

ER -

BibTex |

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BibTex (up to 50 authors) Copy

@article{2013_Kolovskaya,

author = {Olga S. Kolovskaya and Xiaoyan Wang and Mohamed Wehbe and Nadezhda M Titova and Maxim V. Berezovski},

title = {Development of bacteriostatic DNA aptamers for salmonella.},

journal = {Journal of Medicinal Chemistry},

year = {2013},

volume = {56},

publisher = {American Chemical Society (ACS)},

month = {feb},

url = {https://doi.org/10.1021/jm301856j},

number = {4},

pages = {1564--1572},

doi = {10.1021/jm301856j}

}

MLA

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MLA Copy

Kolovskaya, Olga S., et al. “Development of bacteriostatic DNA aptamers for salmonella..” Journal of Medicinal Chemistry, vol. 56, no. 4, Feb. 2013, pp. 1564-1572. https://doi.org/10.1021/jm301856j.