Synthesis and biological evaluation of furanoallocolchicinoids
Yuliya V Voitovich
1
,
Ekaterina S Shegravina
1
,
Nikolay S Sitnikov
1
,
Vladimir I Faerman
1
,
Valery V Fokin
1
,
Sebastien Combes
2
,
Diane Allegro
3
,
Pascal Barbier
3
,
2
3
Publication type: Journal Article
Publication date: 2014-12-24
scimago Q1
wos Q1
SJR: 1.801
CiteScore: 11.5
Impact factor: 6.8
ISSN: 00222623, 15204804
PubMed ID:
25496412
Drug Discovery
Molecular Medicine
Abstract
A series of conformationally flexible furan-derived allocolchicinoids was prepared from commercially available colchicine in good to excellent yields using a three-step reaction sequence. Cytotoxicity studies indicated the potent activity of two compounds against human epithelial and lymphoid cell lines (AsPC-1, HEK293, and Jurkat) as well as against Wnt-1 related murine epithelial cell line W1308. The results of in vitro experiments demonstrated that the major effect of these compounds was the induction of cell cycle arrest in the G2/M phase as a direct consequence of effective tubulin binding. In vivo testing of the most potent furanoallocolchicinoid 10c using C57BL/6 mice inoculated with Wnt-1 tumor cells indicated significant inhibition of the tumor growth.
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Metrics
45
Total citations:
45
Citations from 2024:
4
(8.89%)
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MLA
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GOST
Copy
Voitovich Y. V. et al. Synthesis and biological evaluation of furanoallocolchicinoids // Journal of Medicinal Chemistry. 2014. Vol. 58. No. 2. pp. 692-704.
GOST all authors (up to 50)
Copy
Voitovich Y. V., Shegravina E. S., Sitnikov N. S., Faerman V. I., Fokin V. V., Combes S., Allegro D., Barbier P., Beletskaya I. P., Svirshchevskaya E. V., Schmalz H. Synthesis and biological evaluation of furanoallocolchicinoids // Journal of Medicinal Chemistry. 2014. Vol. 58. No. 2. pp. 692-704.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1021/jm501678w
UR - https://doi.org/10.1021/jm501678w
TI - Synthesis and biological evaluation of furanoallocolchicinoids
T2 - Journal of Medicinal Chemistry
AU - Voitovich, Yuliya V
AU - Shegravina, Ekaterina S
AU - Sitnikov, Nikolay S
AU - Faerman, Vladimir I
AU - Fokin, Valery V
AU - Combes, Sebastien
AU - Allegro, Diane
AU - Barbier, Pascal
AU - Beletskaya, Irina P.
AU - Svirshchevskaya, E. V.
AU - Schmalz, H.-G.
PY - 2014
DA - 2014/12/24
PB - American Chemical Society (ACS)
SP - 692-704
IS - 2
VL - 58
PMID - 25496412
SN - 0022-2623
SN - 1520-4804
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2014_Voitovich,
author = {Yuliya V Voitovich and Ekaterina S Shegravina and Nikolay S Sitnikov and Vladimir I Faerman and Valery V Fokin and Sebastien Combes and Diane Allegro and Pascal Barbier and Irina P. Beletskaya and E. V. Svirshchevskaya and H.-G. Schmalz},
title = {Synthesis and biological evaluation of furanoallocolchicinoids},
journal = {Journal of Medicinal Chemistry},
year = {2014},
volume = {58},
publisher = {American Chemical Society (ACS)},
month = {dec},
url = {https://doi.org/10.1021/jm501678w},
number = {2},
pages = {692--704},
doi = {10.1021/jm501678w}
}
Cite this
MLA
Copy
Voitovich, Yuliya V., et al. “Synthesis and biological evaluation of furanoallocolchicinoids.” Journal of Medicinal Chemistry, vol. 58, no. 2, Dec. 2014, pp. 692-704. https://doi.org/10.1021/jm501678w.
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