Discovery of XL335 (WAY-362450), a Highly Potent, Selective, and Orally Active Agonist of the Farnesoid X Receptor (FXR)
Тип публикации: Journal Article
Дата публикации: 2009-01-21
scimago Q1
wos Q1
БС1
SJR: 1.801
CiteScore: 11.5
Impact factor: 6.8
ISSN: 00222623, 15204804
PubMed ID:
19159286
Drug Discovery
Molecular Medicine
Краткое описание
Azepino[4,5-b]indoles have been identified as potent agonists of the farnesoid X receptor (FXR). In vitro and in vivo optimization has led to the discovery of 6m (XL335, WAY-362450) as a potent, selective, and orally bioavailable FXR agonist (EC(50) = 4 nM, Eff = 149%). Oral administration of 6m to LDLR(-/-) mice results in lowering of cholesterol and triglycerides. Chronic administration in an atherosclerosis model results in significant reduction in aortic arch lesions.
Найдено
Ничего не найдено, попробуйте изменить настройки фильтра.
Для доступа к списку цитирований публикации необходимо авторизоваться.
Топ-30
Журналы
|
1
2
3
4
5
6
7
8
9
|
|
|
Journal of Medicinal Chemistry
9 публикаций, 6%
|
|
|
Bioorganic and Medicinal Chemistry
8 публикаций, 5.33%
|
|
|
Bioorganic and Medicinal Chemistry Letters
7 публикаций, 4.67%
|
|
|
European Journal of Medicinal Chemistry
5 публикаций, 3.33%
|
|
|
Journal of Biological Chemistry
5 публикаций, 3.33%
|
|
|
MedChemComm
5 публикаций, 3.33%
|
|
|
Handbook of Experimental Pharmacology
4 публикации, 2.67%
|
|
|
Journal of Organic Chemistry
4 публикации, 2.67%
|
|
|
Journal of Lipid Research
3 публикации, 2%
|
|
|
Journal of Chemical Information and Modeling
3 публикации, 2%
|
|
|
Hepatology
2 публикации, 1.33%
|
|
|
Frontiers in Pharmacology
2 публикации, 1.33%
|
|
|
Acta Pharmacologica Sinica
2 публикации, 1.33%
|
|
|
Journal of Computer-Aided Molecular Design
2 публикации, 1.33%
|
|
|
Biomedicine and Pharmacotherapy
2 публикации, 1.33%
|
|
|
Molecular and Cellular Endocrinology
2 публикации, 1.33%
|
|
|
Journal of Hepatology
2 публикации, 1.33%
|
|
|
Tetrahedron Letters
2 публикации, 1.33%
|
|
|
Biochemical and Biophysical Research Communications
2 публикации, 1.33%
|
|
|
Asian Journal of Organic Chemistry
2 публикации, 1.33%
|
|
|
ChemistrySelect
2 публикации, 1.33%
|
|
|
Organic Letters
2 публикации, 1.33%
|
|
|
RSC Advances
2 публикации, 1.33%
|
|
|
Expert Opinion on Therapeutic Patents
2 публикации, 1.33%
|
|
|
Molecular Pharmacology
1 публикация, 0.67%
|
|
|
Molecular Endocrinology
1 публикация, 0.67%
|
|
|
Experimental and Molecular Medicine
1 публикация, 0.67%
|
|
|
Future Medicinal Chemistry
1 публикация, 0.67%
|
|
|
Therapeutic Advances in Gastroenterology
1 публикация, 0.67%
|
|
|
1
2
3
4
5
6
7
8
9
|
Издатели
|
5
10
15
20
25
30
35
40
45
50
|
|
|
Elsevier
47 публикаций, 31.33%
|
|
|
American Chemical Society (ACS)
21 публикация, 14%
|
|
|
Springer Nature
20 публикаций, 13.33%
|
|
|
Wiley
13 публикаций, 8.67%
|
|
|
Royal Society of Chemistry (RSC)
9 публикаций, 6%
|
|
|
Taylor & Francis
8 публикаций, 5.33%
|
|
|
American Society for Biochemistry and Molecular Biology
8 публикаций, 5.33%
|
|
|
MDPI
3 публикации, 2%
|
|
|
Frontiers Media S.A.
3 публикации, 2%
|
|
|
Georg Thieme Verlag KG
3 публикации, 2%
|
|
|
American Society for Pharmacology and Experimental Therapeutics
2 публикации, 1.33%
|
|
|
The Endocrine Society
1 публикация, 0.67%
|
|
|
SAGE
1 публикация, 0.67%
|
|
|
Public Library of Science (PLoS)
1 публикация, 0.67%
|
|
|
OOO Zhurnal "Mendeleevskie Soobshcheniya"
1 публикация, 0.67%
|
|
|
KenzPub
1 публикация, 0.67%
|
|
|
American Physiological Society
1 публикация, 0.67%
|
|
|
Zhejiang University Press
1 публикация, 0.67%
|
|
|
Bentham Science Publishers Ltd.
1 публикация, 0.67%
|
|
|
Korean Society for the Study of Obesity
1 публикация, 0.67%
|
|
|
Oxford University Press
1 публикация, 0.67%
|
|
|
5
10
15
20
25
30
35
40
45
50
|
- Мы не учитываем публикации, у которых нет DOI.
- Статистика публикаций обновляется еженедельно.
Вы ученый?
Создайте профиль, чтобы получать персональные рекомендации коллег, конференций и новых статей.
Метрики
150
Всего цитирований:
150
Цитирований c 2025:
8
(5.33%)
Цитировать
ГОСТ |
RIS |
BibTex |
MLA
Цитировать
ГОСТ
Скопировать
Flatt B. et al. Discovery of XL335 (WAY-362450), a Highly Potent, Selective, and Orally Active Agonist of the Farnesoid X Receptor (FXR) // Journal of Medicinal Chemistry. 2009. Vol. 52. No. 4. pp. 904-907.
ГОСТ со всеми авторами (до 50)
Скопировать
Flatt B., Martin R., Wang T. L., Mahaney P., Murphy B., Gu X., Foster P., Li J., Pircher P., Petrowski M., Schulman I. G., WESTIN S., Wrobel J., Yan G., Bischoff E., Daige C., Mohan R. Discovery of XL335 (WAY-362450), a Highly Potent, Selective, and Orally Active Agonist of the Farnesoid X Receptor (FXR) // Journal of Medicinal Chemistry. 2009. Vol. 52. No. 4. pp. 904-907.
Цитировать
RIS
Скопировать
TY - JOUR
DO - 10.1021/jm8014124
UR - https://doi.org/10.1021/jm8014124
TI - Discovery of XL335 (WAY-362450), a Highly Potent, Selective, and Orally Active Agonist of the Farnesoid X Receptor (FXR)
T2 - Journal of Medicinal Chemistry
AU - Flatt, Brenton
AU - Martin, Richard
AU - Wang, Tie Lin
AU - Mahaney, Paige
AU - Murphy, Brett
AU - Gu, Xiao-Hui
AU - Foster, Paul
AU - Li, Jiali
AU - Pircher, Parinaz
AU - Petrowski, Mary
AU - Schulman, Ira G.
AU - WESTIN, STEFAN
AU - Wrobel, Jay
AU - Yan, Grace
AU - Bischoff, Eric
AU - Daige, Chris
AU - Mohan, Raju
PY - 2009
DA - 2009/01/21
PB - American Chemical Society (ACS)
SP - 904-907
IS - 4
VL - 52
PMID - 19159286
SN - 0022-2623
SN - 1520-4804
ER -
Цитировать
BibTex (до 50 авторов)
Скопировать
@article{2009_Flatt,
author = {Brenton Flatt and Richard Martin and Tie Lin Wang and Paige Mahaney and Brett Murphy and Xiao-Hui Gu and Paul Foster and Jiali Li and Parinaz Pircher and Mary Petrowski and Ira G. Schulman and STEFAN WESTIN and Jay Wrobel and Grace Yan and Eric Bischoff and Chris Daige and Raju Mohan},
title = {Discovery of XL335 (WAY-362450), a Highly Potent, Selective, and Orally Active Agonist of the Farnesoid X Receptor (FXR)},
journal = {Journal of Medicinal Chemistry},
year = {2009},
volume = {52},
publisher = {American Chemical Society (ACS)},
month = {jan},
url = {https://doi.org/10.1021/jm8014124},
number = {4},
pages = {904--907},
doi = {10.1021/jm8014124}
}
Цитировать
MLA
Скопировать
Flatt, Brenton, et al. “Discovery of XL335 (WAY-362450), a Highly Potent, Selective, and Orally Active Agonist of the Farnesoid X Receptor (FXR).” Journal of Medicinal Chemistry, vol. 52, no. 4, Jan. 2009, pp. 904-907. https://doi.org/10.1021/jm8014124.