Drug Delivery Systems: Water Soluble Taxol 2‘-Poly(ethylene glycol) Ester ProdrugsDesign and in Vivo Effectiveness
Тип публикации: Journal Article
Дата публикации: 1996-01-01
scimago Q1
wos Q1
БС1
SJR: 1.801
CiteScore: 11.5
Impact factor: 6.8
ISSN: 00222623, 15204804
PubMed ID:
8558510
Drug Discovery
Molecular Medicine
Краткое описание
Water soluble 2'-taxol poly(ethylene glycol) (PEG) esters have been synthesized and shown to function in vitro as prodrugs. However, in vivo experiments clearly establish that in order for these prodrugs to behave in a predictable fashion, the molecular weight of PEG must be of such magnitude so as to maintain a t1/2(circulation) > t1/2(hydrolysis). When PEG derivatives of molecular weight approximately 40 kDa were employed with paclitaxel, ca. 4% by weight of paclitaxel was carried by the water soluble prodrug form, and equivalent in vivo toxicity and increased life expectancy in the P388-treated mouse was observed. An effective method for prescreening prodrugs was found to be the acute murine lethality, which reflects the equivalency of the solubilized transport form and the native drug.
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ГОСТ |
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BibTex |
MLA
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ГОСТ
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Greenwald R. B. et al. Drug Delivery Systems: Water Soluble Taxol 2‘-Poly(ethylene glycol) Ester ProdrugsDesign and in Vivo Effectiveness // Journal of Medicinal Chemistry. 1996. Vol. 39. No. 2. pp. 424-431.
ГОСТ со всеми авторами (до 50)
Скопировать
Greenwald R. B., Gilbert C. W., Pendri A., Conover C. D., Xia J., Martinez A. Drug Delivery Systems: Water Soluble Taxol 2‘-Poly(ethylene glycol) Ester ProdrugsDesign and in Vivo Effectiveness // Journal of Medicinal Chemistry. 1996. Vol. 39. No. 2. pp. 424-431.
Цитировать
RIS
Скопировать
TY - JOUR
DO - 10.1021/jm950475e
UR - https://doi.org/10.1021/jm950475e
TI - Drug Delivery Systems: Water Soluble Taxol 2‘-Poly(ethylene glycol) Ester ProdrugsDesign and in Vivo Effectiveness
T2 - Journal of Medicinal Chemistry
AU - Greenwald, Richard B
AU - Gilbert, Carl W.
AU - Pendri, Annapurna
AU - Conover, Charles D.
AU - Xia, Jing
AU - Martinez, Anthony
PY - 1996
DA - 1996/01/01
PB - American Chemical Society (ACS)
SP - 424-431
IS - 2
VL - 39
PMID - 8558510
SN - 0022-2623
SN - 1520-4804
ER -
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BibTex (до 50 авторов)
Скопировать
@article{1996_Greenwald,
author = {Richard B Greenwald and Carl W. Gilbert and Annapurna Pendri and Charles D. Conover and Jing Xia and Anthony Martinez},
title = {Drug Delivery Systems: Water Soluble Taxol 2‘-Poly(ethylene glycol) Ester ProdrugsDesign and in Vivo Effectiveness},
journal = {Journal of Medicinal Chemistry},
year = {1996},
volume = {39},
publisher = {American Chemical Society (ACS)},
month = {jan},
url = {https://doi.org/10.1021/jm950475e},
number = {2},
pages = {424--431},
doi = {10.1021/jm950475e}
}
Цитировать
MLA
Скопировать
Greenwald, Richard B., et al. “Drug Delivery Systems: Water Soluble Taxol 2‘-Poly(ethylene glycol) Ester ProdrugsDesign and in Vivo Effectiveness.” Journal of Medicinal Chemistry, vol. 39, no. 2, Jan. 1996, pp. 424-431. https://doi.org/10.1021/jm950475e.