Psammaplins from the Sponge Pseudoceratina purpurea: Inhibition of Both Histone Deacetylase and DNA Methyltransferase
Ivette C. Piña
1
,
Jeffrey T Gautschi
1
,
Gui-Yang-Sheng Wang
1
,
Miranda L Sanders
1
,
Francis J Schmitz
1
,
Dennis France
1
,
Susan Cornell-Kennon
1
,
Lidia C Sambucetti
1
,
Stacy W Remiszewski
1
,
Larry B Perez
1
,
Kenneth W Bair
1
,
Phillip Crews
1
Publication type: Journal Article
Publication date: 2003-04-18
scimago Q2
wos Q1
SJR: 0.737
CiteScore: 6.1
Impact factor: 3.6
ISSN: 00223263, 15206904
PubMed ID:
12737565
Organic Chemistry
Abstract
Four novel bisulfide bromotyrosine derivatives, psammaplins E (9), F (10), G (11), and H (12), and two new bromotyrosine derivatives, psammaplins I (13) and J (14), were isolated from the sponge Pseudoceratina purpurea, along with known psammaplins A (4), B (6), C (7), and D (8) and bisaprasin (5). The structures of psammaplins E (9) and F (10), which each contain an oxalyl group rarely found in marine organisms, were determined by spectroscopic analysis. Compounds 4, 5, and 10 are potent histone deacetylase inhibitors and also show mild cytotoxicity. Furthermore, compounds 4, 5, and 11 are potent DNA methyltransferase inhibitors. The biogenetic pathway previously proposed for the psammaplins class is also revisited.
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Total citations:
278
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GOST
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Piña I. C. et al. Psammaplins from the Sponge Pseudoceratina purpurea: Inhibition of Both Histone Deacetylase and DNA Methyltransferase // Journal of Organic Chemistry. 2003. Vol. 68. No. 10. pp. 3866-3873.
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Piña I. C., Gautschi J. T., Wang G., Sanders M. L., Schmitz F. J., France D., Cornell-Kennon S., Sambucetti L. C., Remiszewski S. W., Perez L. B., Bair K. W., Crews P. Psammaplins from the Sponge Pseudoceratina purpurea: Inhibition of Both Histone Deacetylase and DNA Methyltransferase // Journal of Organic Chemistry. 2003. Vol. 68. No. 10. pp. 3866-3873.
Cite this
RIS
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TY - JOUR
DO - 10.1021/jo034248t
UR - https://doi.org/10.1021/jo034248t
TI - Psammaplins from the Sponge Pseudoceratina purpurea: Inhibition of Both Histone Deacetylase and DNA Methyltransferase
T2 - Journal of Organic Chemistry
AU - Piña, Ivette C.
AU - Gautschi, Jeffrey T
AU - Wang, Gui-Yang-Sheng
AU - Sanders, Miranda L
AU - Schmitz, Francis J
AU - France, Dennis
AU - Cornell-Kennon, Susan
AU - Sambucetti, Lidia C
AU - Remiszewski, Stacy W
AU - Perez, Larry B
AU - Bair, Kenneth W
AU - Crews, Phillip
PY - 2003
DA - 2003/04/18
PB - American Chemical Society (ACS)
SP - 3866-3873
IS - 10
VL - 68
PMID - 12737565
SN - 0022-3263
SN - 1520-6904
ER -
Cite this
BibTex (up to 50 authors)
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@article{2003_Piña,
author = {Ivette C. Piña and Jeffrey T Gautschi and Gui-Yang-Sheng Wang and Miranda L Sanders and Francis J Schmitz and Dennis France and Susan Cornell-Kennon and Lidia C Sambucetti and Stacy W Remiszewski and Larry B Perez and Kenneth W Bair and Phillip Crews},
title = {Psammaplins from the Sponge Pseudoceratina purpurea: Inhibition of Both Histone Deacetylase and DNA Methyltransferase},
journal = {Journal of Organic Chemistry},
year = {2003},
volume = {68},
publisher = {American Chemical Society (ACS)},
month = {apr},
url = {https://doi.org/10.1021/jo034248t},
number = {10},
pages = {3866--3873},
doi = {10.1021/jo034248t}
}
Cite this
MLA
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Piña, Ivette C., et al. “Psammaplins from the Sponge Pseudoceratina purpurea: Inhibition of Both Histone Deacetylase and DNA Methyltransferase.” Journal of Organic Chemistry, vol. 68, no. 10, Apr. 2003, pp. 3866-3873. https://doi.org/10.1021/jo034248t.