Alkaloids from the Tunicate Polycarpa aurata from Chuuk Atoll
1
Institute of Biochemistry and Cell Biology, Syntex Discovery Research, Palo Alto, California 94304.
|
Publication type: Journal Article
Publication date: 1996-01-01
scimago Q2
wos Q1
SJR: 0.737
CiteScore: 6.1
Impact factor: 3.6
ISSN: 00223263, 15206904
PubMed ID:
11667102
Organic Chemistry
Abstract
Two new alkaloids, polycarpine (1) and N,N-didesmethylgrossularine-1 (4), have been isolated from extracts of the ascidian Polycarpa aurata collected in Chuuk, Federated States of Micronesia. Three degradation products of 1 were also isolated. The structures of 1, 2, and 4 were determined by X-ray crystallography. The dimeric disulfide 1 inhibited the enzyme inosine monophosphate dehydrogenase, but the inhibition could be reversed by addition of excess dithiothreitol suggesting that 1 reacts with sulfhydryl groups on the enzyme.
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Metrics
61
Total citations:
61
Citations from 2025:
2
(3.28%)
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MLA
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GOST
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Abas S. A. et al. Alkaloids from the Tunicate Polycarpa aurata from Chuuk Atoll // Journal of Organic Chemistry. 1996. Vol. 61. No. 8. pp. 2709-2712.
GOST all authors (up to 50)
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Abas S. A. Alkaloids from the Tunicate Polycarpa aurata from Chuuk Atoll // Journal of Organic Chemistry. 1996. Vol. 61. No. 8. pp. 2709-2712.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1021/jo960040e
UR - https://doi.org/10.1021/jo960040e
TI - Alkaloids from the Tunicate Polycarpa aurata from Chuuk Atoll
T2 - Journal of Organic Chemistry
AU - Abas, Sayed A
PY - 1996
DA - 1996/01/01
PB - American Chemical Society (ACS)
SP - 2709-2712
IS - 8
VL - 61
PMID - 11667102
SN - 0022-3263
SN - 1520-6904
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{1996_Abas,
author = {Sayed A Abas},
title = {Alkaloids from the Tunicate Polycarpa aurata from Chuuk Atoll},
journal = {Journal of Organic Chemistry},
year = {1996},
volume = {61},
publisher = {American Chemical Society (ACS)},
month = {jan},
url = {https://doi.org/10.1021/jo960040e},
number = {8},
pages = {2709--2712},
doi = {10.1021/jo960040e}
}
Cite this
MLA
Copy
Abas, Sayed A., et al. “Alkaloids from the Tunicate Polycarpa aurata from Chuuk Atoll.” Journal of Organic Chemistry, vol. 61, no. 8, Jan. 1996, pp. 2709-2712. https://doi.org/10.1021/jo960040e.