Unusual emitting states of the kindling fluorescent protein: Appearance of the cationic chromophore in the GFP family
Bella Grigorenko
1
,
Bella L Grigorenko
2
,
Igor V. Polyakov
1, 2
,
Alexander P. Savitsky
4
,
Alexander Nemukhin
1, 5
,
Alexander V Nemukhin
2, 6
Publication type: Journal Article
Publication date: 2013-06-06
scimago Q1
wos Q3
SJR: 0.742
CiteScore: 5.3
Impact factor: 2.9
ISSN: 15206106, 15205207, 10895647
PubMed ID:
23697758
Materials Chemistry
Surfaces, Coatings and Films
Physical and Theoretical Chemistry
Abstract
The kindling fluorescent protein (KFP), the Ala143Gly variant of the natural chromoprotein asFP595, is a prospective biomarker in live cells. Following the results of QM/MM calculations, we predict that excitation of the protein under certain conditions, favoring formation of KFP fractions with the neutral chromophore, should result in fluorescence from the cationic form of the chromophore which is unusual for the members of the green fluorescent protein family. Occurrence of the neutral form is due to a water wire connecting the chromophore with the exterior of the protein. Occurrence of the cationic form is due to the excited-state proton transfer from the conserved Glu215 to the imidazolinone ring nitrogen of the chromophore. The emission band from conformations with the trans cationic chromophore should be noticeably shifted to the blue side around 520 nm compared to the well-known red fluorescence around 600 nm arising from the cis anionic species.
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15
Total citations:
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Citations from 2024:
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(6%)
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GOST
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Grigorenko B. et al. Unusual emitting states of the kindling fluorescent protein: Appearance of the cationic chromophore in the GFP family // Journal of Physical Chemistry B. 2013. Vol. 117. No. 24. pp. 7228-7234.
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Grigorenko B., Grigorenko B. L., Polyakov I. V., Savitsky A., Savitsky A. P., Nemukhin A., Nemukhin A. V. Unusual emitting states of the kindling fluorescent protein: Appearance of the cationic chromophore in the GFP family // Journal of Physical Chemistry B. 2013. Vol. 117. No. 24. pp. 7228-7234.
Cite this
RIS
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TY - JOUR
DO - 10.1021/jp402149q
UR - https://pubs.acs.org/doi/10.1021/jp402149q
TI - Unusual emitting states of the kindling fluorescent protein: Appearance of the cationic chromophore in the GFP family
T2 - Journal of Physical Chemistry B
AU - Grigorenko, Bella
AU - Grigorenko, Bella L
AU - Polyakov, Igor V.
AU - Savitsky, Alexander
AU - Savitsky, Alexander P.
AU - Nemukhin, Alexander
AU - Nemukhin, Alexander V
PY - 2013
DA - 2013/06/06
PB - American Chemical Society (ACS)
SP - 7228-7234
IS - 24
VL - 117
PMID - 23697758
SN - 1520-6106
SN - 1520-5207
SN - 1089-5647
ER -
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BibTex (up to 50 authors)
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@article{2013_Grigorenko,
author = {Bella Grigorenko and Bella L Grigorenko and Igor V. Polyakov and Alexander Savitsky and Alexander P. Savitsky and Alexander Nemukhin and Alexander V Nemukhin},
title = {Unusual emitting states of the kindling fluorescent protein: Appearance of the cationic chromophore in the GFP family},
journal = {Journal of Physical Chemistry B},
year = {2013},
volume = {117},
publisher = {American Chemical Society (ACS)},
month = {jun},
url = {https://pubs.acs.org/doi/10.1021/jp402149q},
number = {24},
pages = {7228--7234},
doi = {10.1021/jp402149q}
}
Cite this
MLA
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Grigorenko, Bella, et al. “Unusual emitting states of the kindling fluorescent protein: Appearance of the cationic chromophore in the GFP family.” Journal of Physical Chemistry B, vol. 117, no. 24, Jun. 2013, pp. 7228-7234. https://pubs.acs.org/doi/10.1021/jp402149q.