ACS Nano, volume 6, issue 5, pages 3695-3702

Ag2S Quantum Dot: A Bright and Biocompatible Fluorescent Nanoprobe in the Second Near-Infrared Window

Publication typeJournal Article
Publication date2012-04-27
Journal: ACS Nano
Q1
Q1
SJR4.593
CiteScore26.0
Impact factor15.8
ISSN19360851, 1936086X
PubMed ID:  22515909
General Physics and Astronomy
General Materials Science
General Engineering
Abstract
Ag(2)S quantum dots (QDs) emitting in the second near-infrared region (NIR-II, 1.0-1.4 μm) are demonstrated as a promising fluorescent probe with both bright photoluminescence and high biocompatibility for the first time. Highly selective in vitro targeting and imaging of different cell lines are achieved using biocompatible NIR-II Ag(2)S QDs with different targeting ligands. The cytotoxicity study illustrates the Ag(2)S QDs with negligible effects in altering cell proliferation, triggering apoptosis and necrosis, generating reactive oxygen species, and causing DNA damage. Our results have opened up the possibilities of using these biocompatible Ag(2)S QDs for in vivo anatomical imaging and early stage tumor diagnosis with deep tissue penetration, high sensitivity, and elevated spatial and temporal resolution owing to their high emission efficiency in the unique NIR-II imaging window.
Shen S., Zhang Y., Peng L., Du Y., Wang Q.
2011-06-21 citations by CoLab: 153 Abstract
In recent years, heterostructured nanomaterials have attracted intense research interest due to their integrated multifunctionality of disparate components. Such multifunctionality gives heterostructured nanomaterials great potential in different fields of diagnosis, sensors, catalysis, optoelectronic devices, and so on. In particular, enormous efforts have been devoted to synthesizing different heterodimer nanomaterials, including CoPt3–Au, [3] PbSe–Au, Fe3O4– Au, 5] PbS–Au, Fe3O4–Ag, [7,8] and Ag2S/Ag, [10] which combine optical and/or electrical, magnetic, catalytic properties. Matchstick-shaped heteronanostructures (HNSs) are an important kind of heterostructured nanomaterials which are very suitable for integrating into nanodevices for further applications. Metal-tipped semiconductor nanorod HNSs have been well studied in the last decade. Metal tips (Au, Pt, Co, etc.) were selectively grown on either top or side of CdS/CdSe nanorods, and the resulting metal–semiconductor interface facilitated charge separation, which favored their application in solar energy. Due to the flexibility of bandgap engineering, semiconductor–semiconductor HNSs have been considered to offer better opportunities for internal exciton separation and carrier transport and optoelectronic applications. Recently, we reported that Ag2S quantum dots (QDs) can be good candidates as near-infrared (NIR) emitters, and that ultrathin ZnS nanowires can emit in the UV/blue region. We therefore wondered how HNSs consisting of Ag2S QDs and ZnS nanowires would behave. Recently, Xu et al. prepared Ag2S–ZnS HNSs by a seeded-growth method in which Ag2S nanocrystals acted as catalyst for growth of ZnS nanorods. However, both Ag2S nanocrystals and ZnS nanorods of the as-prepared Ag2S–ZnS HNSs had large diameters of about 20 nm and their optical properties were not reported. Since the Bohr radius of ZnS is 2.4 nm (to the best of our knowledge, that of Ag2S is unknown), we expect that Ag2S–ZnS HNSs with smaller sizes will exhibit their intrinsic optical properties due to the quantum confinement effect. Therefore, the driving force for this work was to determine whether Ag2S–ZnS HNSs with smaller sizes preserve both the NIR and UV/blue emissions or not. Three merits of this work can be noted: 1) The as-prepared small Ag2S–ZnS HNSs exhibit both NIR and UV/blue emissions from Ag2S QDs and ZnS nanorods, respectively; 2) A facile one-pot method is utilized for Ag2S–ZnS HNSs synthesis by thermal co-decomposition of single-source precursors Ag(DDTC) and Zn(DDTC)2 (DDTC = diethyldithiocarbamate), which is much more convenient than the seededgrowth or catalyst-assisted growth method; 3) The size of the HNSs can be easily tuned by changing the reaction conditions, which is not possible for seeded-growth with given seeds. Figure 1a depicts a typical low-magnification TEM image of Ag2S–ZnS HNSs prepared with an Ag(DDTC)/Zn(DDTC)2 molar ratio of 2:1. The HNSs are of uniform matchstick shape with significant difference in the massthickness contrast between the spherical head (ca. 4.5 nm in diameter) and the stem (4 48 nm in diameter and length). The narrow size distribution of as-prepared Ag2S–ZnS HNSs facilitated their self-assembly into superlattice structures with hexagonal packing, which was supported by a selected-area fast Fourier transform (FFT) pattern (inset in Figure 1a). The Ag2S–ZnS HNS superlattices were perpendicular to the TEM grid, as was further confirmed by TEM tilting experiments (see Supporting Information), similar to a previously reported CoO nanorod superlattice. The mass-thickness contrast difference between the spherical head and stem indicated the various chemical compositions of the as-prepared HNSs. A high-resolution TEM (HRTEM) image of a typical Ag2S–ZnS HNS is shown in Figure 1b. The HNS is highly crystalline with a spherical head and a nanorodlike stem, and has a partially coherent interface between single-crystalline head and stem. Based on the analysis of the corresponding crystal lattices, the spherical head is composed of Ag2S and the stem of ZnS, and the conjunction interface consists of the ( 121) plane of the Ag2S head and the (008) plane of the ZnS stem with a lattice mismatch of 16% (Figure 1b). The (008) plane of ZnS was further confirmed by a higher quality HRTEM image (Figure 1c), in which hcp ABAB stacking of ZnS double layers along the [001] direction can be clearly observed. This is a strong evidence that d = 0.31 nm corresponds to the (008) plane of hexagonal ZnS. Detailed analysis of the local elemental composition of the Ag2S–ZnS HNSs was performed by line-scan energy-dispersive X-ray spec[*] Dr. S. Shen, Y. Zhang, L. Peng, Dr. Y. Du, Prof. Dr. Q. Wang Division of Nanobiomedicine andi-Lab, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences Suzhou, 215123 (China) Fax: (+ 86)512-6287-2620 E-mail: qbwang2008@sinano.ac.cn
Welsher K., Sherlock S.P., Dai H.
Fluorescent imaging in the second near-infrared window (NIR II, 1–1.4 μm) holds much promise due to minimal autofluorescence and tissue scattering. Here, using well-functionalized biocompatible single-walled carbon nanotubes (SWNTs) as NIR II fluorescent imaging agents, we performed high-frame-rate video imaging of mice during intravenous injection of SWNTs and investigated the path of SWNTs through the mouse anatomy. We observed in real-time SWNT circulation through the lungs and kidneys several seconds postinjection, and spleen and liver at slightly later time points. Dynamic contrast-enhanced imaging through principal component analysis (PCA) was performed and found to greatly increase the anatomical resolution of organs as a function of time postinjection. Importantly, PCA was able to discriminate organs such as the pancreas, which could not be resolved from real-time raw images. Tissue phantom studies were performed to compare imaging in the NIR II region to the traditional NIR I biological transparency window (700–900 nm). Examination of the feature sizes of a common NIR I dye (indocyanine green) showed a more rapid loss of feature contrast and integrity with increasing feature depth as compared to SWNTs in the NIR II region. The effects of increased scattering in the NIR I versus NIR II region were confirmed by Monte Carlo simulation. In vivo fluorescence imaging in the NIR II region combined with PCA analysis may represent a powerful approach to high-resolution optical imaging through deep tissues, useful for a wide range of applications from biomedical research to disease diagnostics.
Hong G., Tabakman S.M., Welsher K., Chen Z., Robinson J.T., Wang H., Zhang B., Dai H.
2011-04-19 citations by CoLab: 79 Abstract
Prof. H. Dai, G. Hong, S. M. Tabakman, J. T. Robinson, H. Wang, B. Zhang Department of Chemistry, Stanford University, Stanford, California 94305 E-mail: hdai@stanford.edu Dr. K. Welsher Department of Chemistry, Princeton University, Princeton, New Jersey, 08544 Dr. Z. Chen State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, Hunan University, Changsha, Hunan, 410082 (China)
Hong G., Tabakman S.M., Welsher K., Wang H., Wang X., Dai H.
2010-10-27 citations by CoLab: 107 Abstract
The photoluminescence (PL) quantum yield of single-walled carbon nanotubes (SWNTs) is relatively low, with various quenching effects by metallic species reported in the literature. Here, we report the first case of metal enhanced fluorescence (MEF) of surfactant-coated carbon nanotubes on nanostructured gold substrates. The photoluminescence quantum yield of SWNTs is observed to be enhanced more than 10-fold. The dependence of fluorescence enhancement on metal-nanotube distance and on surface plasmon resonance (SPR) of the gold substrate for various SWNT chiralities is measured to reveal the mechanism of enhancement. Surfactant-coated SWNTs in direct contact with metal exhibit strong MEF without quenching, suggesting a small quenching distance for SWNTs on the order of the van der Waals distance, beyond which the intrinsically fast non-radiative decay rate in nanotubes is little enhanced by metal. The metal enhanced fluorescence of SWNTs is attributed to radiative lifetime shortening through resonance coupling of SWNT emission to the re-radiating dipolar plasmonic modes in the metal.
Robinson J.T., Welsher K., Tabakman S.M., Sherlock S.P., Wang H., Luong R., Dai H.
Nano Research Q1 Q1
2010-10-12 citations by CoLab: 444 Abstract
Short single-walled carbon nanotubes (SWNTs) functionalized by PEGylated phospholipids are biologically non-toxic and long-circulating nanomaterials with intrinsic near infrared photoluminescence (NIR PL), characteristic Raman spectra, and strong optical absorbance in the near infrared (NIR). This work demonstrates the first dual application of intravenously injected SWNTs as photoluminescent agents for in vivo tumor imaging in the 1.0–1.4 μm emission region and as NIR absorbers and heaters at 808 nm for photothermal tumor elimination at the lowest injected dose (70 μg of SWNT/mouse, equivalent to 3.6 mg/kg) and laser irradiation power (0.6 W/cm2) reported to date. Ex vivo resonance Raman imaging revealed the SWNT distribution within tumors at a high spatial resolution. Complete tumor elimination was achieved for large numbers of photothermally treated mice without any toxic side effects after more than six months post-treatment. Further, side-by-side experiments were carried out to compare the performance of SWNTs and gold nanorods (AuNRs) at an injected dose of 700 μg of AuNR/mouse (equivalent to 35 mg/kg) in NIR photothermal ablation of tumors in vivo. Highly effective tumor elimination with SWNTs was achieved at 10 times lower injected doses and lower irradiation powers than for AuNRs. These results suggest there are significant benefits of utilizing the intrinsic properties of biocompatible SWNTs for combined cancer imaging and therapy.
Li F., Li K., Cui Z., Zhang Z., Wei H., Gao D., Deng J., Zhang X.
Small Q1 Q1
2010-09-14 citations by CoLab: 44
Zrazhevskiy P., Sena M., Gao X.
2010-08-10 citations by CoLab: 844 Abstract
The emerging field of bionanotechnology aims at revolutionizing biomedical research and clinical practice via introduction of nanoparticle-based tools, expanding capabilities of existing investigative, diagnostic, and therapeutic techniques as well as creating novel instruments and approaches for addressing challenges faced by medicine. Quantum dots (QDs), semiconductor nanoparticles with unique photo-physical properties, have become one of the dominant classes of imaging probes as well as universal platforms for engineering of multifunctional nanodevices. Possessing versatile surface chemistry and superior optical features, QDs have found initial use in a variety of in vitro and in vivo applications. However, careful engineering of QD probes guided by application-specific design criteria is becoming increasingly important for successful transition of this technology from proof-of-concept studies towards real-life clinical applications. This review outlines the major design principles and criteria, from general ones to application-specific, governing the engineering of novel QD probes satisfying the increasing demands and requirements of nanomedicine and discusses the future directions of QD-focused bionanotechnology research (critical review, 201 references).
Yang H., Rivera Z., Jube S., Nasu M., Bertino P., Goparaju C., Franzoso G., Lotze M.T., Krausz T., Pass H.I., Bianchi M.E., Carbone M.
Asbestos carcinogenesis has been linked to the release of cytokines and mutagenic reactive oxygen species (ROS) from inflammatory cells. Asbestos is cytotoxic to human mesothelial cells (HM), which appears counterintuitive for a carcinogen. We show that asbestos-induced HM cell death is a regulated form of necrosis that links to carcinogenesis. Asbestos-exposed HM activate poly(ADP-ribose) polymerase, secrete H 2 O 2 , deplete ATP, and translocate high-mobility group box 1 protein (HMGB1) from the nucleus to the cytoplasm, and into the extracellular space. The release of HMGB1 induces macrophages to secrete TNF-α, which protects HM from asbestos-induced cell death and triggers a chronic inflammatory response; both favor HM transformation. In both mice and hamsters injected with asbestos, HMGB1 was specifically detected in the nuclei, cytoplasm, and extracellular space of mesothelial and inflammatory cells around asbestos deposits. TNF-α was coexpressed in the same areas. HMGB1 levels in asbestos-exposed individuals were significantly higher than in nonexposed controls ( P < 0.0001). Our findings identify the release of HMGB1 as a critical initial step in the pathogenesis of asbestos-related disease, and provide mechanistic links between asbestos-induced cell death, chronic inflammation, and carcinogenesis. Chemopreventive approaches aimed at inhibiting the chronic inflammatory response, and especially blocking HMGB1, may decrease the risk of malignant mesothelioma among asbestos-exposed cohorts.
Zerda A.D., Liu Z., Bodapati S., Teed R., Vaithilingam S., Khuri-Yakub B.T., Chen X., Dai H., Gambhir S.S.
Nano Letters Q1 Q1
2010-05-25 citations by CoLab: 340 Abstract
Photoacoustic imaging is an emerging modality that overcomes to a great extent the resolution and depth limitations of optical imaging while maintaining relatively high-contrast. However, since many diseases will not manifest an endogenous photoacoustic contrast, it is essential to develop exogenous photoacoustic contrast agents that can target diseased tissue(s). Here we present a novel photoacoustic contrast agent, Indocyanine Green dye-enhanced single walled carbon nanotube (SWNT-ICG). We conjugated this contrast agent with cyclic Arg-Gly-Asp (RGD) peptides to molecularly target the alpha(v)beta(3) integrins, which are associated with tumor angiogenesis. Intravenous administration of this tumor-targeted contrast agent to tumor-bearing mice showed significantly higher photoacoustic signal in the tumor than in mice injected with the untargeted contrast agent. The new contrast agent gave a markedly 300 times higher photoacoustic contrast in living tissues than previously reported SWNTs, leading to subnanomolar sensitivities. Finally, we show that the new contrast agent can detect approximately 20 times fewer cancer cells than previously reported SWNTs.
Du Y., Xu B., Fu T., Cai M., Li F., Zhang Y., Wang Q.
2010-01-15 citations by CoLab: 581 Abstract
Monodisperse Ag2S quantum dots (QDs) were synthesized via pyrolysis of Ag(DDTC) in oleic acid, octadecylamine, and 1-octadecene. The uniform alkyl-capped Ag2S QDs with a size of 10.2 nm emit near-IR emission at 1058 nm under 785 nm excitation.
Smith A.M., Mancini M.C., Nie S.
2009-11-09 citations by CoLab: 2340 Abstract
Enhanced fluorescence from carbon nanotubes and advances in near-infrared cameras have opened up a new wavelength window for small animal imaging.
Welsher K., Liu Z., Sherlock S.P., Robinson J.T., Chen Z., Daranciang D., Dai H.
2009-10-11 citations by CoLab: 1069 Abstract
The near-infrared photoluminescence intrinsic to semiconducting single-walled carbon nanotubes is ideal for biological imaging owing to the low autofluorescence and deep tissue penetration in the near-infrared region beyond 1 µm. However, biocompatible single-walled carbon nanotubes with high quantum yield have been elusive. Here, we show that sonicating single-walled carbon nanotubes with sodium cholate, followed by surfactant exchange to form phospholipid–polyethylene glycol coated nanotubes, produces in vivo imaging agents that are both bright and biocompatible. The exchange procedure is better than directly sonicating the tubes with the phospholipid–polyethylene glycol, because it results in less damage to the nanotubes and improves the quantum yield. We show whole-animal in vivo imaging using an InGaAs camera in the 1–1.7 µm spectral range by detecting the intrinsic near-infrared photoluminescence of the ‘exchange’ single-walled carbon nanotubes at a low dose (17 mg l−1 injected dose). The deep tissue penetration and low autofluorescence background allowed high-resolution intravital microscopy imaging of tumour vessels beneath thick skin. Single-walled carbon nanotubes can be modified into bright and biocompatible agents for high resolution whole-animal imaging at wavelengths in the 1100–1700 nm region.
Liu Z., Tabakman S.M., Chen Z., Dai H.
2009-09-03 citations by CoLab: 360 Abstract
Biomedical applications of carbon nanotubes have attracted much attention in recent years. Here, we summarize our previously developed protocols for functionalization and bioconjugation of single-walled carbon nanotubes (SWNTs) for various biomedical applications including biological imaging; using nanotubes as Raman, photoluminescence and photoacoustic labels; sensing using nanotubes as Raman tags and drug delivery. Sonication of SWNTs in solutions of phospholipid-polyethylene glycol (PL-PEG) is our most commonly used protocol of SWNT functionalization. Compared with other frequently used covalent strategies, our non-covalent functionalization protocol largely retains the intrinsic optical properties of SWNTs, which are useful in various biological imaging and sensing applications. Functionalized SWNTs are conjugated with targeting ligands, including peptides and antibodies for specific cell labeling in vitro or tumor targeting in vivo. Radio labels are introduced for tracking and imaging of SWNTs in real time in vivo. Moreover, SWNTs can be conjugated with small interfering RNA (siRNA) or loaded with chemotherapy drugs for drug delivery. These procedures take various times ranging from 1 to 5 d.
Liu Z., Tabakman S., Welsher K., Dai H.
Nano Research Q1 Q1 Open Access
2009-02-03 citations by CoLab: 1412 Abstract
Carbon nanotubes exhibit many unique intrinsic physical and chemical properties and have been intensively explored for biological and biomedical applications in the past few years. In this comprehensive review, we summarize the main results from our and other groups in this field and clarify that surface functionalization is critical to the behavior of carbon nanotubes in biological systems. Ultrasensitive detection of biological species with carbon nanotubes can be realized after surface passivation to inhibit the non-specific binding of biomolecules on the hydrophobic nanotube surface. Electrical nanosensors based on nanotubes provide a label-free approach to biological detection. Surface-enhanced Raman spectroscopy of carbon nanotubes opens up a method of protein microarray with detection sensitivity down to 1 fmol/L. In vitro and in vivo toxicity studies reveal that highly water soluble and serum stable nanotubes are biocompatible, nontoxic, and potentially useful for biomedical applications. In vivo biodistributions vary with the functionalization and possibly also size of nanotubes, with a tendency to accumulate in the reticuloendothelial system (RES), including the liver and spleen, after intravenous administration. If well functionalized, nanotubes may be excreted mainly through the biliary pathway in feces. Carbon nanotube-based drug delivery has shown promise in various In vitro and in vivo experiments including delivery of small interfering RNA (siRNA), paclitaxel and doxorubicin. Moreover, single-walled carbon nanotubes with various interesting intrinsic optical properties have been used as novel photoluminescence, Raman, and photoacoustic contrast agents for imaging of cells and animals. Further multidisciplinary explorations in this field may bring new opportunities in the realm of biomedicine.
AshaRani P.V., Low Kah Mun G., Hande M.P., Valiyaveettil S.
ACS Nano Q1 Q1
2008-12-30 citations by CoLab: 2960 Abstract
Silver nanoparticles (Ag-np) are being used increasingly in wound dressings, catheters, and various household products due to their antimicrobial activity. The toxicity of starch-coated silver nanoparticles was studied using normal human lung fibroblast cells (IMR-90) and human glioblastoma cells (U251). The toxicity was evaluated using changes in cell morphology, cell viability, metabolic activity, and oxidative stress. Ag-np reduced ATP content of the cell caused damage to mitochondria and increased production of reactive oxygen species (ROS) in a dose-dependent manner. DNA damage, as measured by single cell gel electrophoresis (SCGE) and cytokinesis blocked micronucleus assay (CBMN), was also dose-dependent and more prominent in the cancer cells. The nanoparticle treatment caused cell cycle arrest in G(2)/M phase possibly due to repair of damaged DNA. Annexin-V propidium iodide (PI) staining showed no massive apoptosis or necrosis. The transmission electron microscopic (TEM) analysis indicated the presence of Ag-np inside the mitochondria and nucleus, implicating their direct involvement in the mitochondrial toxicity and DNA damage. A possible mechanism of toxicity is proposed which involves disruption of the mitochondrial respiratory chain by Ag-np leading to production of ROS and interruption of ATP synthesis, which in turn cause DNA damage. It is anticipated that DNA damage is augmented by deposition, followed by interactions of Ag-np to the DNA leading to cell cycle arrest in the G(2)/M phase. The higher sensitivity of U251 cells and their arrest in G(2)/M phase could be explored further for evaluating the potential use of Ag-np in cancer therapy.
Sevim Ünlütürk S., Taşcıoğlu D., Ozcelik S.
2024-12-17 citations by CoLab: 0 Abstract
Abstract This review focuses on the recent progress of wet-chemistry-based synthesis methods for infrared (IR) colloidal quantum dots (CQD), semiconductor nanocrystals with a narrow energy bandgap that absorbs and/or emits infrared photos covering from 0.7 to 25 micrometers. The sections of the review are colloidal synthesis, precursor reactivity, cation exchange, doping and de-doping, surface passivation and ligand exchange, intraband transitions, quenching and purification, and future directions. The colloidal synthesis section is organized based on precursors employed: toxic substances such as mercury- and lead-based metals and non-toxic substances such as indium- and silver-based metal precursors. CQDs are prepared by wet-chemical methods that offer advantages such as precise spectral tunability by adjusting particle size or particle composition, easy fabrication and integration of solution-based CQDs (as inks) with complementary metal-oxide-semiconductors, reduced cost of material manufacturing, and good performances of IR CQD-made optoelectronic devices for non-military applications. These advantages may allow facile and materials’ cost-reduced device fabrications that make CQD-based infrared technologies accessible compared to optoelectronic devices utilizing epitaxially grown semiconductors. However, precursor libraries should be advanced to improve colloidal infrared quantum dot synthesis, enabling CQD-based IR technologies to be available to consumer electronics. As the attention of academia and industry to CQDs continues to proliferate, the progress of precursor chemistry for IR CQDs could be rapid.
Chandra J., Nasir N., Wahab S., Sahebkar A., Kesharwani P.
Nanomedicine Q1 Q2
2024-11-15 citations by CoLab: 0
Mossburg K.J., Shepherd S.J., Barragan D., O N.H., Berkow E.K., Maidment P.S., Rosario Berrios D.N., Hsu J.C., Siedlik M.J., Yadavali S., Mitchell M.J., Issadore D., Cormode D.P.
2024-11-12 citations by CoLab: 0 PDF Abstract
Abstract Purpose Ultrasmall silver sulfide nanoparticles (Ag2S-NP) have been identified as promising contrast agents for a number of modalities and in particular for dual-energy mammography. These Ag2S-NP have demonstrated marked advantages over clinically available agents with the ability to generate higher contrast with high biocompatibility. However, current synthesis methods for inorganic nanoparticles are low-throughput and highly time-intensive, limiting the possibility of large animal studies or eventual clinical use of this potential imaging agent. Methods We herein report the use of a scalable silicon microfluidic system (SSMS) for the large-scale synthesis of Ag2S-NP. Ag2S-NP produced using this system were compared to bulk synthesis and a commercially available microfluidic device through characterization, contrast generation, in vivo imaging, and clearance profiles. Results Using SSMS chips with 1 channel, 10 parallelized channels, and 256 parallelized channels, we determined that the Ag2S-NP produced were of similar quality as measured by core size, concentration, UV–visible spectrometry, and in vitro contrast generation. Moreover, by combining parallelized chips with increasing reagent concentration, we were able to increase output by an overall factor of 5,100. We also found that in vivo imaging contrast generation was consistent across synthesis methods and confirmed renal clearance of the ultrasmall nanoparticles. Finally, we found best-in-class clearance of the Ag2S-NP occurred within 24 h. Conclusions These studies have identified a promising method for the large-scale production of Ag2S-NP, paving the way for eventual clinical translation.
Wegner K.D., Hildebrandt N.
2024-11-01 citations by CoLab: 0
Yang H., Ma Z., Wang Q.
ACS Nano Q1 Q1
2024-10-23 citations by CoLab: 0
Zhao Y., Su M., Wu Z., Yang W., Du Y., Pang Y., Li N., Li Y., Xing B., Zhang J., Wang Z.
2024-10-09 citations by CoLab: 0
Zhang Z., Yang H., Wang M., Zhang Y., Jiang J., Wang Q.
Nano Research Q1 Q1
2024-09-28 citations by CoLab: 0 Abstract
Silver-based quantum dots (QDs) such as Ag2S, Ag2Se, and Ag2Te, which emit in the second near-infrared window (NIR-II, 900–1700 nm), have attracted great research interest due to their prominent optical properties and eco-friendly compositions. Over the past decade, the controllable synthesis, bandgap modulation, and fluorescence improvement of NIR-II Ag-based QDs have greatly promoted their practical applications. In this review, we summarize the development process and latest achievements of NIR-II Ag-based QDs, covering major synthesis techniques for fabricating NIR-II Ag-based QDs, general methods for improving their fluorescence properties and recent advances in the applications of NIR-II Ag-based QDs from bioimaging to optoelectronic devices. Finally, we discuss the challenges and prospects of NIR-II Ag-based QDs in their optical properties and applications. This review aims to present synthesis and modification strategies and future application prospects for NIR-II Ag-based QDs, providing guidance for the design and integration of fluorescent probes in NIR-II window.
Hansen C., Jagtap J., Parchur A., Sharma G., Shafiee S., Sinha S., Himburg H., Joshi A.
2024-09-26 citations by CoLab: 0
Wang P., Morales-Márquez R., Cervás G., Hernández Medel A., Paris Ogayar M., Jimenez de Aberasturi D., de Isidro-Gomez A.I., Torres-Pardo A., Palomares F.J., Garcia-Orrit S., Sousa C.T., Espinosa A., Telle H.H., Ortgies D.H., Vega-Mayoral V., et. al.
2024-09-25 citations by CoLab: 0 Abstract
This study presents the synthesis of bright Ag2S-based nanocrystals, explores the temperature dependence of their photoluminescence quantum yield, and assesses their effectiveness in near-infrared subtissue imaging under mimicked conditions.
Zhong X., Patel A., Sun Y., Saeboe A.M., Dennis A.
2024-09-12 citations by CoLab: 0 Abstract
AbstractMultiplexed fluorescence in vivo imaging remains challenging due to the attenuation and scattering of visible and traditional near infrared (NIR‐I, 650–950 nm) wavelengths. Fluorescence imaging using shortwave infrared (SWIR, 1000–1700 nm, a.k.a. NIR‐II) light enables deeper tissue penetration due to reduced tissue scattering as well as minimal background autofluorescence. SWIR‐emitting semiconductor quantum dots (QDs) with tunable emission peaks and optical stability are powerful contrast agents, yet few imaging demonstrations exclusively use SWIR emission beyond two‐color imaging schemes. In this study, we engineered three high quality lead sulfide/cadmium sulfide (PbS/CdS) core/shell QDs with distinct SWIR emission peaks ranging from 1100–1550 nm for simultaneous three‐color imaging in mice. We first use the exceptional photostability of QDs to non‐invasively track lymphatic drainage with longitudinal imaging, highlighting the detailed networks of lymphatic vessels with widefield imaging over a 2 hr period. We then perform multiplexed imaging with all three QDs to distinctly visualize the lymphatic system and spatially overlapping vasculature networks, including clearly distinguishing the liver and spleen. This work establishes optimized SWIR QDs for next generation multiplexed and longitudinal preclinical imaging, unlocking numerous opportunities for preclinical studies of disease progression, drug biodistribution, and cell trafficking dynamics in living organisms.
Zhong X., Patel A., Sun Y., Saeboe A.M., Dennis A.
2024-09-12 citations by CoLab: 0 Abstract
AbstractMultiplexed fluorescence in vivo imaging remains challenging due to the attenuation and scattering of visible and traditional near infrared (NIR‐I, 650–950 nm) wavelengths. Fluorescence imaging using shortwave infrared (SWIR, 1000–1700 nm, a.k.a. NIR‐II) light enables deeper tissue penetration due to reduced tissue scattering as well as minimal background autofluorescence. SWIR‐emitting semiconductor quantum dots (QDs) with tunable emission peaks and optical stability are powerful contrast agents, yet few imaging demonstrations exclusively use SWIR emission beyond two‐color imaging schemes. In this study, we engineered three high quality lead sulfide/cadmium sulfide (PbS/CdS) core/shell QDs with distinct SWIR emission peaks ranging from 1100–1550 nm for simultaneous three‐color imaging in mice. We first use the exceptional photostability of QDs to non‐invasively track lymphatic drainage with longitudinal imaging, highlighting the detailed networks of lymphatic vessels with widefield imaging over a 2 hr period. We then perform multiplexed imaging with all three QDs to distinctly visualize the lymphatic system and spatially overlapping vasculature networks, including clearly distinguishing the liver and spleen. This work establishes optimized SWIR QDs for next generation multiplexed and longitudinal preclinical imaging, unlocking numerous opportunities for preclinical studies of disease progression, drug biodistribution, and cell trafficking dynamics in living organisms.
Guo J., Zhu Y., Qu Y., Zhang L., Fang M., Xu Z., Wang T., Qin Y., Xu Y., Li Y., Chen Y., Fu H., Liu X., Liu Y., Liu C., et. al.
2024-09-05 citations by CoLab: 0
Arumugasamy S.K., Chellasamy G., Murugan N., Govindaraju S., Yun K., Choi M.
2024-09-01 citations by CoLab: 1 Abstract
Quantum dots (QDs), a novel category of semiconductor materials, exhibit extraordinary capabilities in tuning optical characteristics. Their emergence in biophotonics has been noteworthy, particularly in bio-imaging, biosensing, and theranostics applications. Although conventional QDs such as PbS, CdSe, CdS, and HgTe have garnered attention for their promising features, the presence of heavy metals in these QDs poses significant challenges for biological use. To address these concerns, the development of Ag chalcogenide QDs has gained prominence owing to their near-infrared emission and exceptionally low toxicity, rendering them suitable for biological applications. This review explores recent advancements in Ag chalcogenide QDs, focusing on their synthesis methodologies, surface chemistry modifications, and wide-ranging applications in biomedicine. Additionally, it identifies future directions in material science, highlighting the potential of these innovative QDs in revolutionizing the field.
de Wit J.W., Zabala-Gutierrez I., Marin R., Zhakeyev A., Melle S., Calderon O.G., Marques-Hueso J., Jaque D., Rubio-Retama J., Meijerink A.
2024-08-08 citations by CoLab: 2

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