ACS Nano

, том 7 , издание 6 , страницы 5320-5329

Photosensitizer-Loaded Gold Vesicles with Strong Plasmonic Coupling Effect for Imaging-Guided Photothermal/Photodynamic Therapy

Тип публикации: Journal Article

Дата публикации: 2013-05-30

American Chemical Society (ACS)

ACS Nano

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SJR: 4.102

CiteScore: 23.1

Impact factor: 16

ISSN: 19360851, 1936086X

DOI: 10.1021/nn4011686

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PubMed ID: 23721576

General Physics and Astronomy

General Materials Science

General Engineering

Краткое описание

A multifunctional theranostic platform based on photosensitizer-loaded plasmonic vesicular assemblies of gold nanoparticles (GNPs) is developed for effective cancer imaging and treatment. The gold vesicles (GVs) composed of a monolayer of assembled GNPs show strong absorbance in the near-infrared (NIR) range of 650-800 nm, as a result of the plasmonic coupling effect between neighboring GNPs in the vesicular membranes. The strong NIR absorption and the capability of encapsulating photosensitizer Ce6 in GVs enable trimodality NIR fluorescence/thermal/photoacoustic imaging-guided synergistic photothermal/photodynamic therapy (PTT/PDT) with improved efficacy. The Ce6-loaded GVs (GV-Ce6) have the following characteristics: (i) high Ce6 loading efficiency (up to ~18.4 wt %; (ii) enhanced cellular uptake efficiency of Ce6; (iii) simultaneous trimodality NIR fluorescence/thermal/photoacoustic imaging; (iv) synergistic PTT/PDT treatment with improved efficacy using single wavelength continuous wave laser irradiation.

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Lin J. et al. Photosensitizer-Loaded Gold Vesicles with Strong Plasmonic Coupling Effect for Imaging-Guided Photothermal/Photodynamic Therapy // ACS Nano. 2013. Vol. 7. No. 6. pp. 5320-5329.

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Lin J., Wang S., Huang P., Wang Z., Chen S., Gang Niu G. N., Li W., He J., Cui D., Lu G. M., Chen X., Nie Z. Photosensitizer-Loaded Gold Vesicles with Strong Plasmonic Coupling Effect for Imaging-Guided Photothermal/Photodynamic Therapy // ACS Nano. 2013. Vol. 7. No. 6. pp. 5320-5329.

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TY - JOUR

DO - 10.1021/nn4011686

UR - https://doi.org/10.1021/nn4011686

TI - Photosensitizer-Loaded Gold Vesicles with Strong Plasmonic Coupling Effect for Imaging-Guided Photothermal/Photodynamic Therapy

T2 - ACS Nano

AU - Lin, Jiabao

AU - Wang, Shouju

AU - Huang, Peng

AU - Wang, Zhe

AU - Chen, Shouhui

AU - Gang Niu, Gang Niu

AU - Li, Wanwan

AU - He, Jie

AU - Cui, Da-xiang

AU - Lu, Guang Ming

AU - Chen, Xiaoyuan

AU - Nie, Zhihong

PY - 2013

DA - 2013/05/30

PB - American Chemical Society (ACS)

SP - 5320-5329

IS - 6

VL - 7

PMID - 23721576

SN - 1936-0851

SN - 1936-086X

ER -

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@article{2013_Lin,

author = {Jiabao Lin and Shouju Wang and Peng Huang and Zhe Wang and Shouhui Chen and Gang Niu Gang Niu and Wanwan Li and Jie He and Da-xiang Cui and Guang Ming Lu and Xiaoyuan Chen and Zhihong Nie},

title = {Photosensitizer-Loaded Gold Vesicles with Strong Plasmonic Coupling Effect for Imaging-Guided Photothermal/Photodynamic Therapy},

journal = {ACS Nano},

year = {2013},

volume = {7},

publisher = {American Chemical Society (ACS)},

month = {may},

url = {https://doi.org/10.1021/nn4011686},

number = {6},

pages = {5320--5329},

doi = {10.1021/nn4011686}

}

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Lin, Jiabao, et al. “Photosensitizer-Loaded Gold Vesicles with Strong Plasmonic Coupling Effect for Imaging-Guided Photothermal/Photodynamic Therapy.” ACS Nano, vol. 7, no. 6, May. 2013, pp. 5320-5329. https://doi.org/10.1021/nn4011686.

Издатель

American Chemical Society (ACS)

Журнал

ACS Nano

SCImago Q1

Tоп 10% SCImago

WOS Q1

БС1