ACS Nano

, volume 7 , issue 6 , pages 5320-5329

Photosensitizer-Loaded Gold Vesicles with Strong Plasmonic Coupling Effect for Imaging-Guided Photothermal/Photodynamic Therapy

Jiabao Lin ^{1, 2}

Shouju Wang ^{3, 4}

Peng Huang ^{2, 3}

Zhe Wang ^{3, 5}

Shouhui Chen ^{2, 3}

Gang Niu Gang Niu ³

Wanwan Li ³

Jie He ¹

Da-xiang Cui ²

Guang Ming Lu ⁴

Xiaoyuan Chen ³

Zhihong Nie ¹

Hide authors affiliations Show authors affiliations: 5 affiliations

Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742, United States |

Institute of Micro-Nano Science and Technology, Shanghai Jiao Tong University, Shanghai 200240, China |

Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health, Bethesda, Maryland 20892, United States |

⁴

Jinling Hospital, Clinical School of Medical College, Nanjing University, Nanjing, 210000, China |

⁵

Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361005, China |

Publication type: Journal Article

Publication date: 2013-05-30

American Chemical Society (ACS)

ACS Nano

scimago Q1

wos Q1

SJR: 4.497

CiteScore: 24.2

Impact factor: 16.0

ISSN: 19360851, 1936086X

DOI: 10.1021/nn4011686

Copy DOI

PubMed ID: 23721576

General Physics and Astronomy

General Materials Science

General Engineering

Abstract

A multifunctional theranostic platform based on photosensitizer-loaded plasmonic vesicular assemblies of gold nanoparticles (GNPs) is developed for effective cancer imaging and treatment. The gold vesicles (GVs) composed of a monolayer of assembled GNPs show strong absorbance in the near-infrared (NIR) range of 650-800 nm, as a result of the plasmonic coupling effect between neighboring GNPs in the vesicular membranes. The strong NIR absorption and the capability of encapsulating photosensitizer Ce6 in GVs enable trimodality NIR fluorescence/thermal/photoacoustic imaging-guided synergistic photothermal/photodynamic therapy (PTT/PDT) with improved efficacy. The Ce6-loaded GVs (GV-Ce6) have the following characteristics: (i) high Ce6 loading efficiency (up to ~18.4 wt %; (ii) enhanced cellular uptake efficiency of Ce6; (iii) simultaneous trimodality NIR fluorescence/thermal/photoacoustic imaging; (iv) synergistic PTT/PDT treatment with improved efficacy using single wavelength continuous wave laser irradiation.

Found

1 citation

Smirnov Evgeny

🥼 🤝

PhD in Chemistry, associate professor

38 publications, 930 citations, 3 reviews

1 citation

Soldatov Alexander

600 publications, 11 181 citations

h-index: 52

Southern Federal University

1 citation

Filippov Anatoly

🥼 🤝

DSc in Physics and Mathematics

105 publications, 815 citations

h-index: 16

Troitsk Institute for Innovation and Fusion Research

Joint Institute for High Temperatures of the Russian Academy of Sciences

Moscow Institute of Physics and Technology

Pushkov Institute of Terrestrial Magnetism, Ionosphere and Radiowave Propagation of Russian Academy of Sciences

Research interests

Statistical physics

1 citation

ULLAH NASEEB

21 publications, 807 citations

h-index: 15

Research interests

Green chemistry

Heterogeneous catalysis

Nanomaterials

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594

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GOST |

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GOST Copy

Lin J. et al. Photosensitizer-Loaded Gold Vesicles with Strong Plasmonic Coupling Effect for Imaging-Guided Photothermal/Photodynamic Therapy // ACS Nano. 2013. Vol. 7. No. 6. pp. 5320-5329.

GOST all authors (up to 50) Copy

Lin J., Wang S., Huang P., Wang Z., Chen S., Gang Niu G. N., Li W., He J., Cui D., Lu G. M., Chen X., Nie Z. Photosensitizer-Loaded Gold Vesicles with Strong Plasmonic Coupling Effect for Imaging-Guided Photothermal/Photodynamic Therapy // ACS Nano. 2013. Vol. 7. No. 6. pp. 5320-5329.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1021/nn4011686

UR - https://doi.org/10.1021/nn4011686

TI - Photosensitizer-Loaded Gold Vesicles with Strong Plasmonic Coupling Effect for Imaging-Guided Photothermal/Photodynamic Therapy

T2 - ACS Nano

AU - Lin, Jiabao

AU - Wang, Shouju

AU - Huang, Peng

AU - Wang, Zhe

AU - Chen, Shouhui

AU - Gang Niu, Gang Niu

AU - Li, Wanwan

AU - He, Jie

AU - Cui, Da-xiang

AU - Lu, Guang Ming

AU - Chen, Xiaoyuan

AU - Nie, Zhihong

PY - 2013

DA - 2013/05/30

PB - American Chemical Society (ACS)

SP - 5320-5329

IS - 6

VL - 7

PMID - 23721576

SN - 1936-0851

SN - 1936-086X

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2013_Lin,

author = {Jiabao Lin and Shouju Wang and Peng Huang and Zhe Wang and Shouhui Chen and Gang Niu Gang Niu and Wanwan Li and Jie He and Da-xiang Cui and Guang Ming Lu and Xiaoyuan Chen and Zhihong Nie},

title = {Photosensitizer-Loaded Gold Vesicles with Strong Plasmonic Coupling Effect for Imaging-Guided Photothermal/Photodynamic Therapy},

journal = {ACS Nano},

year = {2013},

volume = {7},

publisher = {American Chemical Society (ACS)},

month = {may},

url = {https://doi.org/10.1021/nn4011686},

number = {6},

pages = {5320--5329},

doi = {10.1021/nn4011686}

}

MLA

Cite this

MLA Copy

Lin, Jiabao, et al. “Photosensitizer-Loaded Gold Vesicles with Strong Plasmonic Coupling Effect for Imaging-Guided Photothermal/Photodynamic Therapy.” ACS Nano, vol. 7, no. 6, May. 2013, pp. 5320-5329. https://doi.org/10.1021/nn4011686.

Publisher

American Chemical Society (ACS)

Journal

ACS Nano

scimago Q1

wos Q1

SJR

4.497

CiteScore

24.2

Impact factor

16.0

ISSN

19360851 (Print)

1936086X (Electronic)