Isolation and in Vitro Antiplasmodial Activities of Alkaloids from Teclea trichocarpa: In Vivo Antimalarial Activity and X-ray Crystal Structure of Normelicopicine
Тип публикации: Journal Article
Дата публикации: 2002-06-13
scimago Q1
wos Q1
БС1
SJR: 0.629
CiteScore: 6.5
Impact factor: 3.6
ISSN: 01633864, 15206025
PubMed ID:
12141852
Organic Chemistry
Drug Discovery
Pharmacology
Pharmaceutical Science
Molecular Medicine
Complementary and alternative medicine
Analytical Chemistry
Краткое описание
Seven alkaloids have been isolated from Teclea trichocarpa including four, normelicopicine (1), arborinine (2), skimmianine (6), and dictamnine (7), that are reported for the first time in addition to the previously reported alkaloids melicopicine (3), tecleanthine (4), and 6-methoxytecleanthine (5). The structure of 1 was confirmed by single-crystal X-ray crystallography. Two alkaloids, 1 and 2, displayed limited in vitro activities against Plasmodium falciparum strains HB3 and K1, but there appeared to be little cross-resistance with chloroquine. Alkaloid 1 was found to have some activity against P. berghei in mice (32% suppression of parasitaemia at a dose of 25 mg x kg(-1) x day(-1)), but unlike chloroquine it did not inhibit beta-haematin formation in a cell-free system; 1 was found to have low in vitro cytotoxicity to KB cells (IC50 > 328 microM).
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Muriithi M. W. et al. Isolation and in Vitro Antiplasmodial Activities of Alkaloids from Teclea trichocarpa: In Vivo Antimalarial Activity and X-ray Crystal Structure of Normelicopicine // Journal of Natural Products. 2002. Vol. 65. No. 7. pp. 956-959.
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Muriithi M. W., Abraham W. R., Addae-Kyereme J., Scowen I., Croft S. L., Gitu P. M., Kendrick H., Njagi E., Wright C. Isolation and in Vitro Antiplasmodial Activities of Alkaloids from Teclea trichocarpa: In Vivo Antimalarial Activity and X-ray Crystal Structure of Normelicopicine // Journal of Natural Products. 2002. Vol. 65. No. 7. pp. 956-959.
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TY - JOUR
DO - 10.1021/np0106182
UR - https://doi.org/10.1021/np0106182
TI - Isolation and in Vitro Antiplasmodial Activities of Alkaloids from Teclea trichocarpa: In Vivo Antimalarial Activity and X-ray Crystal Structure of Normelicopicine
T2 - Journal of Natural Products
AU - Muriithi, Mary W
AU - Abraham, W. R.
AU - Addae-Kyereme, Jonathan
AU - Scowen, Ian
AU - Croft, Simon L.
AU - Gitu, Peter M
AU - Kendrick, Howard
AU - Njagi, E.N.M
AU - Wright, Colin
PY - 2002
DA - 2002/06/13
PB - American Chemical Society (ACS)
SP - 956-959
IS - 7
VL - 65
PMID - 12141852
SN - 0163-3864
SN - 1520-6025
ER -
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@article{2002_Muriithi,
author = {Mary W Muriithi and W. R. Abraham and Jonathan Addae-Kyereme and Ian Scowen and Simon L. Croft and Peter M Gitu and Howard Kendrick and E.N.M Njagi and Colin Wright},
title = {Isolation and in Vitro Antiplasmodial Activities of Alkaloids from Teclea trichocarpa: In Vivo Antimalarial Activity and X-ray Crystal Structure of Normelicopicine},
journal = {Journal of Natural Products},
year = {2002},
volume = {65},
publisher = {American Chemical Society (ACS)},
month = {jun},
url = {https://doi.org/10.1021/np0106182},
number = {7},
pages = {956--959},
doi = {10.1021/np0106182}
}
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MLA
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Muriithi, Mary W., et al. “Isolation and in Vitro Antiplasmodial Activities of Alkaloids from Teclea trichocarpa: In Vivo Antimalarial Activity and X-ray Crystal Structure of Normelicopicine.” Journal of Natural Products, vol. 65, no. 7, Jun. 2002, pp. 956-959. https://doi.org/10.1021/np0106182.