Acaricidal Activity of Tonka Bean Extracts. Synthesis and Structure−Activity Relationships of Bioactive Derivatives
Christophe Gleye
1
,
Guy Lewin
1
,
Alain Laurens
1
,
Jean-Christophe Jullian
1
,
Philippe M. Loiseau
1
,
Christian Bories
1
,
Reynald HOCQUEMILLER
1
Publication type: Journal Article
Publication date: 2003-05-01
scimago Q1
wos Q1
SJR: 0.629
CiteScore: 6.5
Impact factor: 3.6
ISSN: 01633864, 15206025
PubMed ID:
12762809
Organic Chemistry
Drug Discovery
Pharmacology
Pharmaceutical Science
Molecular Medicine
Complementary and alternative medicine
Analytical Chemistry
Abstract
The acaricidal effects of tonka bean, Dipterix odorata, extracts were investigated on Dermatophagoides pteronyssinus, the European house dust mite, and compared with benzyl benzoate as a standard acaricidal compound. A cyclohexane extract was the most effective, with an EC(50) = 0.075 g/m(2) after a 24 h period, as compared with benzyl benzoate (0.025 g/m(2)). Bioassay-guided fractionation of this extract led to the isolation of coumarin (1). Pharmacomodulation of this compound led us to test 20 analogues (2-21), which were either synthesized or purchased.
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Metrics
30
Total citations:
30
Citations from 2025:
3
(10%)
Cite this
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BibTex |
MLA
Cite this
GOST
Copy
Gleye C. et al. Acaricidal Activity of Tonka Bean Extracts. Synthesis and Structure−Activity Relationships of Bioactive Derivatives // Journal of Natural Products. 2003. Vol. 66. No. 5. pp. 690-692.
GOST all authors (up to 50)
Copy
Gleye C., Lewin G., Laurens A., Jullian J., Loiseau P. M., Bories C., HOCQUEMILLER R. Acaricidal Activity of Tonka Bean Extracts. Synthesis and Structure−Activity Relationships of Bioactive Derivatives // Journal of Natural Products. 2003. Vol. 66. No. 5. pp. 690-692.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1021/np020563j
UR - https://doi.org/10.1021/np020563j
TI - Acaricidal Activity of Tonka Bean Extracts. Synthesis and Structure−Activity Relationships of Bioactive Derivatives
T2 - Journal of Natural Products
AU - Gleye, Christophe
AU - Lewin, Guy
AU - Laurens, Alain
AU - Jullian, Jean-Christophe
AU - Loiseau, Philippe M.
AU - Bories, Christian
AU - HOCQUEMILLER, Reynald
PY - 2003
DA - 2003/05/01
PB - American Chemical Society (ACS)
SP - 690-692
IS - 5
VL - 66
PMID - 12762809
SN - 0163-3864
SN - 1520-6025
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2003_Gleye,
author = {Christophe Gleye and Guy Lewin and Alain Laurens and Jean-Christophe Jullian and Philippe M. Loiseau and Christian Bories and Reynald HOCQUEMILLER},
title = {Acaricidal Activity of Tonka Bean Extracts. Synthesis and Structure−Activity Relationships of Bioactive Derivatives},
journal = {Journal of Natural Products},
year = {2003},
volume = {66},
publisher = {American Chemical Society (ACS)},
month = {may},
url = {https://doi.org/10.1021/np020563j},
number = {5},
pages = {690--692},
doi = {10.1021/np020563j}
}
Cite this
MLA
Copy
Gleye, Christophe, et al. “Acaricidal Activity of Tonka Bean Extracts. Synthesis and Structure−Activity Relationships of Bioactive Derivatives.” Journal of Natural Products, vol. 66, no. 5, May. 2003, pp. 690-692. https://doi.org/10.1021/np020563j.