Tubulin-Interactive Natural Products as Anticancer Agents
Publication type: Journal Article
Publication date: 2009-01-06
scimago Q1
wos Q1
SJR: 0.629
CiteScore: 6.5
Impact factor: 3.6
ISSN: 01633864, 15206025
PubMed ID:
19125622
Organic Chemistry
Drug Discovery
Pharmacology
Pharmaceutical Science
Molecular Medicine
Complementary and alternative medicine
Analytical Chemistry
Abstract
This review provides an overview of the discovery, structures, and biological activities of anticancer natural products that act by inhibiting or promoting the assembly of tubulin to microtubules. The emphasis is on providing recent information on those compounds in clinical use or in advanced clinical trials. The vinca alkaloids, the combretastatins, NPI-2358, the halichondrin B analogue eribulin, dolastatin 10, noscapine, hemiasterlin, and rhizoxin are discussed as tubulin polymerization inhibitors, while the taxanes and the epothilones are the major classes of tubulin polymerization promoters presented, with brief treatments of discodermolide, eleutherobin, and laulimalide. The challenges and future directions of tubulin-interactive natural products-based drug discovery programs are also discussed briefly.
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281
Total citations:
281
Citations from 2024:
17
(6.05%)
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GOST
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Kingston D. Tubulin-Interactive Natural Products as Anticancer Agents // Journal of Natural Products. 2009. Vol. 72. No. 3. pp. 507-515.
GOST all authors (up to 50)
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Kingston D. Tubulin-Interactive Natural Products as Anticancer Agents // Journal of Natural Products. 2009. Vol. 72. No. 3. pp. 507-515.
Cite this
RIS
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TY - JOUR
DO - 10.1021/np800568j
UR - https://doi.org/10.1021/np800568j
TI - Tubulin-Interactive Natural Products as Anticancer Agents
T2 - Journal of Natural Products
AU - Kingston, David
PY - 2009
DA - 2009/01/06
PB - American Chemical Society (ACS)
SP - 507-515
IS - 3
VL - 72
PMID - 19125622
SN - 0163-3864
SN - 1520-6025
ER -
Cite this
BibTex (up to 50 authors)
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@article{2009_Kingston,
author = {David Kingston},
title = {Tubulin-Interactive Natural Products as Anticancer Agents},
journal = {Journal of Natural Products},
year = {2009},
volume = {72},
publisher = {American Chemical Society (ACS)},
month = {jan},
url = {https://doi.org/10.1021/np800568j},
number = {3},
pages = {507--515},
doi = {10.1021/np800568j}
}
Cite this
MLA
Copy
Kingston, David. “Tubulin-Interactive Natural Products as Anticancer Agents.” Journal of Natural Products, vol. 72, no. 3, Jan. 2009, pp. 507-515. https://doi.org/10.1021/np800568j.