Organic Letters

, volume 2 , issue 11 , pages 1581-1583

Solid Phase Syntheses of Polyamine Toxins HO-416b and PhTX-433. Use of an Efficient Polyamide Reduction Strategy That Facilitates Access to Branched Analogues

Fan Wang ¹

Sukhdev Manku ¹

Dennis G. Hall ¹

Hide authors affiliations Show authors affiliations: 1 affiliation

Department of Chemistry, University of Alberta, Edmonton, Alberta, T6G 2G2 Canada |

Publication type: Journal Article

Publication date: 2000-05-05

American Chemical Society (ACS)

Organic Letters

scimago Q1

wos Q1

SJR: 1.235

CiteScore: 8.7

Impact factor: 5.0

ISSN: 15237060, 15237052

DOI: 10.1021/ol005817b

Copy DOI

PubMed ID: 10841484

Organic Chemistry

Biochemistry

Physical and Theoretical Chemistry

Abstract

[structure--se text] Polyamine toxins HO-416b (1) and PhTX-433 (2) isolated from the venom of insects are important lead compounds in neuropharmacology. Their total synthesis has been achieved on a trityl derivatized resin in good yield and purity using a mild borane reduction protocol to access the polyamine chains from polyamide precursors. The synthesis of PhTX isomer 3 demonstrates the potential of this strategy for the generation of branched analogues.

Found

1 citation

Beloglazkina Elena

DSc in Chemistry, professor

297 publications, 3 293 citations, 11 reviews

h-index: 30

Lomonosov Moscow State University

1 citation

Uspenskaya Anastasia

🥼 🤝

PhD in Chemistry

21 publications, 239 citations

h-index: 9

Lomonosov Moscow State University

1 citation

Tihonov Denis

DSc, associate member of the Russian Academy of Sciences

115 publications, 2 464 citations, 2 reviews

h-index: 30

I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences

Top-30

Journals

	1 2 3 4 5
Tetrahedron Letters	Tetrahedron Letters, 5, 12.5% Tetrahedron Letters 5 publications, 12.5%
Tetrahedron	Tetrahedron, 5, 12.5% Tetrahedron 5 publications, 12.5%
Journal of the American Chemical Society	Journal of the American Chemical Society, 2, 5% Journal of the American Chemical Society 2 publications, 5%
Synthesis	Synthesis, 2, 5% Synthesis 2 publications, 5%
Organic Letters	Organic Letters, 1, 2.5% Organic Letters 1 publication, 2.5%
Current Medicinal Chemistry	Current Medicinal Chemistry, 1, 2.5% Current Medicinal Chemistry 1 publication, 2.5%
Bioorganic and Medicinal Chemistry Letters	Bioorganic and Medicinal Chemistry Letters, 1, 2.5% Bioorganic and Medicinal Chemistry Letters 1 publication, 2.5%
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 1, 2.5% International Journal of Molecular Sciences 1 publication, 2.5%
Toxins	Toxins, 1, 2.5% Toxins 1 publication, 2.5%
Molecules	Molecules, 1, 2.5% Molecules 1 publication, 2.5%
Journal of the Iranian Chemical Society	Journal of the Iranian Chemical Society, 1, 2.5% Journal of the Iranian Chemical Society 1 publication, 2.5%
Physiology and Molecular Biology of Plants	Physiology and Molecular Biology of Plants, 1, 2.5% Physiology and Molecular Biology of Plants 1 publication, 2.5%
Bioorganic and Medicinal Chemistry	Bioorganic and Medicinal Chemistry, 1, 2.5% Bioorganic and Medicinal Chemistry 1 publication, 2.5%
Toxicon	Toxicon, 1, 2.5% Toxicon 1 publication, 2.5%
Chemistry - A European Journal	Chemistry - A European Journal, 1, 2.5% Chemistry - A European Journal 1 publication, 2.5%
Medicinal Research Reviews	Medicinal Research Reviews, 1, 2.5% Medicinal Research Reviews 1 publication, 2.5%
ChemBioChem	ChemBioChem, 1, 2.5% ChemBioChem 1 publication, 2.5%
Angewandte Chemie	Angewandte Chemie, 1, 2.5% Angewandte Chemie 1 publication, 2.5%
Angewandte Chemie - International Edition	Angewandte Chemie - International Edition, 1, 2.5% Angewandte Chemie - International Edition 1 publication, 2.5%
ChemMedChem	ChemMedChem, 1, 2.5% ChemMedChem 1 publication, 2.5%
Journal of Combinatorial Chemistry	Journal of Combinatorial Chemistry, 1, 2.5% Journal of Combinatorial Chemistry 1 publication, 2.5%
Natural Product Reports	Natural Product Reports, 1, 2.5% Natural Product Reports 1 publication, 2.5%
Organic and Biomolecular Chemistry	Organic and Biomolecular Chemistry, 1, 2.5% Organic and Biomolecular Chemistry 1 publication, 2.5%
RSC Advances	RSC Advances, 1, 2.5% RSC Advances 1 publication, 2.5%
Studies in Natural Products Chemistry	Studies in Natural Products Chemistry, 1, 2.5% Studies in Natural Products Chemistry 1 publication, 2.5%
Mendeleev Communications	Mendeleev Communications, 1, 2.5% Mendeleev Communications 1 publication, 2.5%
Synlett	Synlett, 1, 2.5% Synlett 1 publication, 2.5%
	1 2 3 4 5

Publishers

	2 4 6 8 10 12 14 16
Elsevier	Elsevier, 15, 37.5% Elsevier 15 publications, 37.5%
Wiley	Wiley, 6, 15% Wiley 6 publications, 15%
American Chemical Society (ACS)	American Chemical Society (ACS), 4, 10% American Chemical Society (ACS) 4 publications, 10%
MDPI	MDPI, 3, 7.5% MDPI 3 publications, 7.5%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 3, 7.5% Royal Society of Chemistry (RSC) 3 publications, 7.5%
Georg Thieme Verlag KG	Georg Thieme Verlag KG, 3, 7.5% Georg Thieme Verlag KG 3 publications, 7.5%
Springer Nature	Springer Nature, 2, 5% Springer Nature 2 publications, 5%
Bentham Science Publishers Ltd.	Bentham Science Publishers Ltd., 1, 2.5% Bentham Science Publishers Ltd. 1 publication, 2.5%
	2 4 6 8 10 12 14 16

We do not take into account publications without a DOI.
Statistics recalculated weekly.

Are you a researcher?

Create a profile to get free access to personal recommendations for colleagues and new articles.

Metrics

Cite this

GOST |

Cite this

GOST Copy

Wang F., Manku S., Hall D. G. Solid Phase Syntheses of Polyamine Toxins HO-416b and PhTX-433. Use of an Efficient Polyamide Reduction Strategy That Facilitates Access to Branched Analogues // Organic Letters. 2000. Vol. 2. No. 11. pp. 1581-1583.

GOST all authors (up to 50) Copy

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1021/ol005817b

UR - https://doi.org/10.1021/ol005817b

TI - Solid Phase Syntheses of Polyamine Toxins HO-416b and PhTX-433. Use of an Efficient Polyamide Reduction Strategy That Facilitates Access to Branched Analogues

T2 - Organic Letters

AU - Wang, Fan

AU - Manku, Sukhdev

AU - Hall, Dennis G.

PY - 2000

DA - 2000/05/05

PB - American Chemical Society (ACS)

SP - 1581-1583

IS - 11

VL - 2

PMID - 10841484

SN - 1523-7060

SN - 1523-7052

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2000_Wang,

author = {Fan Wang and Sukhdev Manku and Dennis G. Hall},

title = {Solid Phase Syntheses of Polyamine Toxins HO-416b and PhTX-433. Use of an Efficient Polyamide Reduction Strategy That Facilitates Access to Branched Analogues},

journal = {Organic Letters},

year = {2000},

volume = {2},

publisher = {American Chemical Society (ACS)},

month = {may},

url = {https://doi.org/10.1021/ol005817b},

number = {11},

pages = {1581--1583},

doi = {10.1021/ol005817b}

}

MLA

Cite this

MLA Copy

Wang, Fan, et al. “Solid Phase Syntheses of Polyamine Toxins HO-416b and PhTX-433. Use of an Efficient Polyamide Reduction Strategy That Facilitates Access to Branched Analogues.” Organic Letters, vol. 2, no. 11, May. 2000, pp. 1581-1583. https://doi.org/10.1021/ol005817b.

Publisher

American Chemical Society (ACS)

Journal

Organic Letters

scimago Q1

wos Q1

SJR

1.235

CiteScore

8.7

Impact factor

5.0

ISSN

15237060 (Print)

15237052 (Electronic)