Organic Letters, volume 13, issue 19, pages 5016-5019
Direct C2-Alkylation of Azoles with Alcohols and Ethers through Dehydrogenative Cross-Coupling under Metal-Free Conditions
Publication type: Journal Article
Publication date: 2011-08-29
Journal:
Organic Letters
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 5.2
ISSN: 15237060, 15237052
Organic Chemistry
Biochemistry
Physical and Theoretical Chemistry
Abstract
A metal-free novel, simple, and highly efficient method for the direct C2-alkylation of azoles with alcohols and ethers has been developed on the basis of an oxidative C–H activation process. The dehydrogenative C–C cross-coupling reactions of α-position sp3 C–H in alcohols and ethers with the 2-position sp2 C–H in azoles proceeded smoothly in the presence of tert-butyl hydroperoxide (TBHP) under neat reaction conditions, which generated the corresponding products in good yields.
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1 publication, 0.51%
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25
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Citations by publishers
10
20
30
40
50
60
70
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62 publications, 31.47%
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1 publication, 0.51%
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Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii
1 publication, 0.51%
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10
20
30
40
50
60
70
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- We do not take into account publications without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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He T. et al. Direct C2-Alkylation of Azoles with Alcohols and Ethers through Dehydrogenative Cross-Coupling under Metal-Free Conditions // Organic Letters. 2011. Vol. 13. No. 19. pp. 5016-5019.
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He T., Lin Yu., Zhang L., Wang L., Wang M. Direct C2-Alkylation of Azoles with Alcohols and Ethers through Dehydrogenative Cross-Coupling under Metal-Free Conditions // Organic Letters. 2011. Vol. 13. No. 19. pp. 5016-5019.
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TY - JOUR
DO - 10.1021/ol201779n
UR - https://doi.org/10.1021/ol201779n
TI - Direct C2-Alkylation of Azoles with Alcohols and Ethers through Dehydrogenative Cross-Coupling under Metal-Free Conditions
T2 - Organic Letters
AU - Lin, Yu
AU - He, Tao
AU - Zhang, Lei
AU - Wang, Lei
AU - Wang, Min
PY - 2011
DA - 2011/08/29 00:00:00
PB - American Chemical Society (ACS)
SP - 5016-5019
IS - 19
VL - 13
SN - 1523-7060
SN - 1523-7052
ER -
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@article{2011_He,
author = {Yu Lin and Tao He and Lei Zhang and Lei Wang and Min Wang},
title = {Direct C2-Alkylation of Azoles with Alcohols and Ethers through Dehydrogenative Cross-Coupling under Metal-Free Conditions},
journal = {Organic Letters},
year = {2011},
volume = {13},
publisher = {American Chemical Society (ACS)},
month = {aug},
url = {https://doi.org/10.1021/ol201779n},
number = {19},
pages = {5016--5019},
doi = {10.1021/ol201779n}
}
Cite this
MLA
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He, Tao, et al. “Direct C2-Alkylation of Azoles with Alcohols and Ethers through Dehydrogenative Cross-Coupling under Metal-Free Conditions.” Organic Letters, vol. 13, no. 19, Aug. 2011, pp. 5016-5019. https://doi.org/10.1021/ol201779n.