Utilization of ReactIR in Fit for Purpose Process Enablement
1
Pharmaceutical Sciences—Research API, Pfizer Global Research & Development Eastern Point Road, Groton, Connecticut 06340, United States
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Publication type: Journal Article
Publication date: 2014-12-18
scimago Q1
wos Q1
SJR: 0.865
CiteScore: 5.4
Impact factor: 3.5
ISSN: 10836160, 1520586X
Organic Chemistry
Physical and Theoretical Chemistry
Abstract
An efficient four-step synthesis of 1 is described in which utilization of ReactIR was key to efficient processing and reaction monitoring. Key chemical steps included (i) nucleophilic aromatic substitution, iron reduction of aromatic nitro group to aniline, (ii) decarboxylation, and (iii) ester formation.
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Metrics
21
Total citations:
21
Citations from 2025:
0
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GOST
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Eisenbeis S. A. et al. Utilization of ReactIR in Fit for Purpose Process Enablement // Organic Process Research and Development. 2014. Vol. 19. No. 1. pp. 244-248.
GOST all authors (up to 50)
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Eisenbeis S. A., Chen R., Kang M., Barrila M., Buzon R. Utilization of ReactIR in Fit for Purpose Process Enablement // Organic Process Research and Development. 2014. Vol. 19. No. 1. pp. 244-248.
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RIS
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TY - JOUR
DO - 10.1021/op5003165
UR - https://doi.org/10.1021/op5003165
TI - Utilization of ReactIR in Fit for Purpose Process Enablement
T2 - Organic Process Research and Development
AU - Eisenbeis, Shane A.
AU - Chen, Raymond
AU - Kang, Ming
AU - Barrila, Mark
AU - Buzon, Richard
PY - 2014
DA - 2014/12/18
PB - American Chemical Society (ACS)
SP - 244-248
IS - 1
VL - 19
SN - 1083-6160
SN - 1520-586X
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2014_Eisenbeis,
author = {Shane A. Eisenbeis and Raymond Chen and Ming Kang and Mark Barrila and Richard Buzon},
title = {Utilization of ReactIR in Fit for Purpose Process Enablement},
journal = {Organic Process Research and Development},
year = {2014},
volume = {19},
publisher = {American Chemical Society (ACS)},
month = {dec},
url = {https://doi.org/10.1021/op5003165},
number = {1},
pages = {244--248},
doi = {10.1021/op5003165}
}
Cite this
MLA
Copy
Eisenbeis, Shane A., et al. “Utilization of ReactIR in Fit for Purpose Process Enablement.” Organic Process Research and Development, vol. 19, no. 1, Dec. 2014, pp. 244-248. https://doi.org/10.1021/op5003165.