Second-Generation Process for the HCV Protease Inhibitor BILN 2061: A Greener Approach to Ru-Catalyzed Ring-Closing Metathesis
Тип публикации: Journal Article
Дата публикации: 2009-01-14
SCImago Q1
WOS Q1
БС1
SJR: 0.876
CiteScore: 5.8
Impact factor: 3.3
ISSN: 10836160, 1520586X
Organic Chemistry
Physical and Theoretical Chemistry
Краткое описание
The ring-closing metathesis (RCM) step, a key reaction in our process to BILN 2061, was dramatically improved from the first-generation process by the selection of a more appropriate substrate as well as the use of a more effective catalyst. The two RCM reactions are compared in detail using criteria that are of high significance to the process chemist.
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Метрики
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MLA
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ГОСТ
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Farina V. et al. Second-Generation Process for the HCV Protease Inhibitor BILN 2061: A Greener Approach to Ru-Catalyzed Ring-Closing Metathesis // Organic Process Research and Development. 2009. Vol. 13. No. 2. pp. 250-254.
ГОСТ со всеми авторами (до 50)
Скопировать
Farina V., Shu C., Zeng X., Wei X., Han Z., Yee N. K., Senanayake C. H. Second-Generation Process for the HCV Protease Inhibitor BILN 2061: A Greener Approach to Ru-Catalyzed Ring-Closing Metathesis // Organic Process Research and Development. 2009. Vol. 13. No. 2. pp. 250-254.
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RIS
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TY - JOUR
DO - 10.1021/op800225f
UR - https://doi.org/10.1021/op800225f
TI - Second-Generation Process for the HCV Protease Inhibitor BILN 2061: A Greener Approach to Ru-Catalyzed Ring-Closing Metathesis
T2 - Organic Process Research and Development
AU - Farina, Vittorio
AU - Shu, Chutian
AU - Zeng, Xingzhong
AU - Wei, Xudong
AU - Han, Zhengxu
AU - Yee, Nathan K.
AU - Senanayake, Chris H.
PY - 2009
DA - 2009/01/14
PB - American Chemical Society (ACS)
SP - 250-254
IS - 2
VL - 13
SN - 1083-6160
SN - 1520-586X
ER -
Цитировать
BibTex (до 50 авторов)
Скопировать
@article{2009_Farina,
author = {Vittorio Farina and Chutian Shu and Xingzhong Zeng and Xudong Wei and Zhengxu Han and Nathan K. Yee and Chris H. Senanayake},
title = {Second-Generation Process for the HCV Protease Inhibitor BILN 2061: A Greener Approach to Ru-Catalyzed Ring-Closing Metathesis},
journal = {Organic Process Research and Development},
year = {2009},
volume = {13},
publisher = {American Chemical Society (ACS)},
month = {jan},
url = {https://doi.org/10.1021/op800225f},
number = {2},
pages = {250--254},
doi = {10.1021/op800225f}
}
Цитировать
MLA
Скопировать
Farina, Vittorio, et al. “Second-Generation Process for the HCV Protease Inhibitor BILN 2061: A Greener Approach to Ru-Catalyzed Ring-Closing Metathesis.” Organic Process Research and Development, vol. 13, no. 2, Jan. 2009, pp. 250-254. https://doi.org/10.1021/op800225f.
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