Attrition-Enhanced Deracemization in the Synthesis of Clopidogrel - A Practical Application of a New Discovery
Тип публикации: Journal Article
Дата публикации: 2009-11-04
scimago Q1
wos Q1
БС1
SJR: 0.865
CiteScore: 5.4
Impact factor: 3.5
ISSN: 10836160, 1520586X
Organic Chemistry
Physical and Theoretical Chemistry
Краткое описание
The recently discovered technique of deracemization by means of attrition-induced grinding of a solid conglomerate in contact with a solution wherein racemization occurs has been used with a derivative of 2-chlorophenyl glycine, the key chiral component in the synthesis of Clopidogrel (Plavix). Deracemization of the racemate proceeds to a single enantiomer and in essentially absolute enantiomeric excess. Further conversion of enantiomerically pure material to Clopidogrel was achieved in 88% yield.
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Van Der Meijden M. W. et al. Attrition-Enhanced Deracemization in the Synthesis of Clopidogrel - A Practical Application of a New Discovery // Organic Process Research and Development. 2009. Vol. 13. No. 6. pp. 1195-1198.
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Van Der Meijden M. W., Leeman M., Gelens E., Noorduin W. L., Meekes H., Van Enckevort W. J. P., Kaptein B., Vlieg E., Kellogg R. M. Attrition-Enhanced Deracemization in the Synthesis of Clopidogrel - A Practical Application of a New Discovery // Organic Process Research and Development. 2009. Vol. 13. No. 6. pp. 1195-1198.
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TY - JOUR
DO - 10.1021/op900243c
UR - https://doi.org/10.1021/op900243c
TI - Attrition-Enhanced Deracemization in the Synthesis of Clopidogrel - A Practical Application of a New Discovery
T2 - Organic Process Research and Development
AU - Van Der Meijden, Maarten W
AU - Leeman, Michel
AU - Gelens, Edith
AU - Noorduin, Wim L.
AU - Meekes, H.
AU - Van Enckevort, Willem J P
AU - Kaptein, Bernard
AU - Vlieg, E.
AU - Kellogg, Richard M
PY - 2009
DA - 2009/11/04
PB - American Chemical Society (ACS)
SP - 1195-1198
IS - 6
VL - 13
SN - 1083-6160
SN - 1520-586X
ER -
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@article{2009_Van Der Meijden,
author = {Maarten W Van Der Meijden and Michel Leeman and Edith Gelens and Wim L. Noorduin and H. Meekes and Willem J P Van Enckevort and Bernard Kaptein and E. Vlieg and Richard M Kellogg},
title = {Attrition-Enhanced Deracemization in the Synthesis of Clopidogrel - A Practical Application of a New Discovery},
journal = {Organic Process Research and Development},
year = {2009},
volume = {13},
publisher = {American Chemical Society (ACS)},
month = {nov},
url = {https://doi.org/10.1021/op900243c},
number = {6},
pages = {1195--1198},
doi = {10.1021/op900243c}
}
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MLA
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Van Der Meijden, Maarten W., et al. “Attrition-Enhanced Deracemization in the Synthesis of Clopidogrel - A Practical Application of a New Discovery.” Organic Process Research and Development, vol. 13, no. 6, Nov. 2009, pp. 1195-1198. https://doi.org/10.1021/op900243c.