In vivo biodistribution and highly efficient tumour targeting of carbon nanotubes in mice
Publication type: Journal Article
Publication date: 2006-12-17
scimago Q1
wos Q1
SJR: 14.612
CiteScore: 62.2
Impact factor: 34.9
ISSN: 17483387, 17483395
PubMed ID:
18654207
Atomic and Molecular Physics, and Optics
Condensed Matter Physics
General Materials Science
Electrical and Electronic Engineering
Bioengineering
Biomedical Engineering
Abstract
Single-walled carbon nanotubes (SWNTs) exhibit unique size, shape and physical properties1,2,3 that make them promising candidates for biological applications. Here, we investigate the biodistribution of radio-labelled SWNTs in mice by in vivo positron emission tomography (PET), ex vivo biodistribution and Raman spectroscopy. It is found that SWNTs that are functionalized with phospholipids bearing polyethylene-glycol (PEG) are surprisingly stable in vivo. The effect of PEG chain length on the biodistribution and circulation of the SWNTs is studied. Effectively PEGylated SWNTs exhibit relatively long blood circulation times and low uptake by the reticuloendothelial system (RES). Efficient targeting of integrin positive tumour in mice is achieved with SWNTs coated with PEG chains linked to an arginine–glycine–aspartic acid (RGD) peptide. A high tumour accumulation is attributed to the multivalent effect of the SWNTs. The Raman signatures of SWNTs are used to directly probe the presence of nanotubes in mice tissues and confirm the radio-label-based results.
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Liu Z. et al. In vivo biodistribution and highly efficient tumour targeting of carbon nanotubes in mice // Nature Nanotechnology. 2006. Vol. 2. No. 1. pp. 47-52.
GOST all authors (up to 50)
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Liu Z., Cai W., He L., Nakayama N., Chen K., Sun X., Chen X., Dai H. In vivo biodistribution and highly efficient tumour targeting of carbon nanotubes in mice // Nature Nanotechnology. 2006. Vol. 2. No. 1. pp. 47-52.
Cite this
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TY - JOUR
DO - 10.1038/nnano.2006.170
UR - https://doi.org/10.1038/nnano.2006.170
TI - In vivo biodistribution and highly efficient tumour targeting of carbon nanotubes in mice
T2 - Nature Nanotechnology
AU - Liu, Zhuang
AU - Cai, Weibo
AU - He, Lina
AU - Nakayama, Nozomi
AU - Chen, Kai
AU - Sun, Xiaoming
AU - Chen, Xiaoyuan
AU - Dai, Hongjie
PY - 2006
DA - 2006/12/17
PB - Springer Nature
SP - 47-52
IS - 1
VL - 2
PMID - 18654207
SN - 1748-3387
SN - 1748-3395
ER -
Cite this
BibTex (up to 50 authors)
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@article{2006_Liu,
author = {Zhuang Liu and Weibo Cai and Lina He and Nozomi Nakayama and Kai Chen and Xiaoming Sun and Xiaoyuan Chen and Hongjie Dai},
title = {In vivo biodistribution and highly efficient tumour targeting of carbon nanotubes in mice},
journal = {Nature Nanotechnology},
year = {2006},
volume = {2},
publisher = {Springer Nature},
month = {dec},
url = {https://doi.org/10.1038/nnano.2006.170},
number = {1},
pages = {47--52},
doi = {10.1038/nnano.2006.170}
}
Cite this
MLA
Copy
Liu, Zhuang, et al. “In vivo biodistribution and highly efficient tumour targeting of carbon nanotubes in mice.” Nature Nanotechnology, vol. 2, no. 1, Dec. 2006, pp. 47-52. https://doi.org/10.1038/nnano.2006.170.