Open Access
Mesenchymal stromal cells facilitate resolution of pulmonary fibrosis by miR-29c and miR-129 intercellular transfer
Mikhail Arbatskiy
2
,
Vladimir Popov
1, 2
,
Olga Grigorieva
1
,
Maksim Vigovskiy
1, 2
,
Zaytsev Ivan
2
,
Ekaterina Novoseletskaya
1
,
Georgy Sagaradze
1, 2
,
Natalia Danilova
2, 3
,
Pavel Malkov
2, 3
,
Cherniaev Andrey
4, 5
,
Maria Samsonova
4, 5
,
Maxim Karagyaur
1, 2
,
Tolstoluzhinskaya Anastasiya
1, 2
,
Uliana Dyachkova
2
,
Zhanna Akopyan
1, 2
,
Vsevolod Tkachuk
1, 2
,
Natalia Kalinina
2
,
Efimenko Anastasiya
1, 2
Publication type: Journal Article
Publication date: 2023-07-03
scimago Q1
wos Q1
SJR: 4.001
CiteScore: 17.2
Impact factor: 12.9
ISSN: 12263613, 20966413, 20926413
PubMed ID:
37394579
Biochemistry
Molecular Biology
Clinical Biochemistry
Molecular Medicine
Abstract
To date, pulmonary fibrosis remains an unmet medical need. In this study, we evaluated the potency of mesenchymal stromal cell (MSC) secretome components to prevent pulmonary fibrosis development and facilitate fibrosis resolution. Surprisingly, the intratracheal application of extracellular vesicles (MSC-EVs) or the vesicle-depleted secretome fraction (MSC-SF) was not able to prevent lung fibrosis when applied immediately after the injury caused by bleomycin instillation in mice. However, MSC-EV administration induced the resolution of established pulmonary fibrosis, whereas the vesicle-depleted fraction did not. The application of MSC-EVs caused a decrease in the numbers of myofibroblasts and FAPa+ progenitors without affecting their apoptosis. Such a decrease likely occurred due to their dedifferentiation caused by microRNA (miR) transfer by MSC-EVs. Using a murine model of bleomycin-induced pulmonary fibrosis, we confirmed the contribution of specific miRs (miR-29c and miR-129) to the antifibrotic effect of MSC-EVs. Our study provides novel insights into possible antifibrotic therapy based on the use of the vesicle-enriched fraction of the MSC secretome.
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Metrics
32
Total citations:
32
Citations from 2024:
27
(84.38%)
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MLA
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GOST
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Basalova N. et al. Mesenchymal stromal cells facilitate resolution of pulmonary fibrosis by miR-29c and miR-129 intercellular transfer // Experimental and Molecular Medicine. 2023. Vol. 55. No. 7. pp. 1399-1412.
GOST all authors (up to 50)
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Basalova N., Arbatskiy M., Popov V., Grigorieva O., Vigovskiy M., Ivan Z., Novoseletskaya E., Sagaradze G., Danilova N., Malkov P., Andrey C., Samsonova M., Karagyaur M., Anastasiya T., Dyachkova U., Akopyan Z., Tkachuk V., Kalinina N., Anastasiya E. Mesenchymal stromal cells facilitate resolution of pulmonary fibrosis by miR-29c and miR-129 intercellular transfer // Experimental and Molecular Medicine. 2023. Vol. 55. No. 7. pp. 1399-1412.
Cite this
RIS
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TY - JOUR
DO - 10.1038/s12276-023-01017-w
UR - https://doi.org/10.1038/s12276-023-01017-w
TI - Mesenchymal stromal cells facilitate resolution of pulmonary fibrosis by miR-29c and miR-129 intercellular transfer
T2 - Experimental and Molecular Medicine
AU - Basalova, Nataliya
AU - Arbatskiy, Mikhail
AU - Popov, Vladimir
AU - Grigorieva, Olga
AU - Vigovskiy, Maksim
AU - Ivan, Zaytsev
AU - Novoseletskaya, Ekaterina
AU - Sagaradze, Georgy
AU - Danilova, Natalia
AU - Malkov, Pavel
AU - Andrey, Cherniaev
AU - Samsonova, Maria
AU - Karagyaur, Maxim
AU - Anastasiya, Tolstoluzhinskaya
AU - Dyachkova, Uliana
AU - Akopyan, Zhanna
AU - Tkachuk, Vsevolod
AU - Kalinina, Natalia
AU - Anastasiya, Efimenko
PY - 2023
DA - 2023/07/03
PB - Springer Nature
SP - 1399-1412
IS - 7
VL - 55
PMID - 37394579
SN - 1226-3613
SN - 2096-6413
SN - 2092-6413
ER -
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BibTex (up to 50 authors)
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@article{2023_Basalova,
author = {Nataliya Basalova and Mikhail Arbatskiy and Vladimir Popov and Olga Grigorieva and Maksim Vigovskiy and Zaytsev Ivan and Ekaterina Novoseletskaya and Georgy Sagaradze and Natalia Danilova and Pavel Malkov and Cherniaev Andrey and Maria Samsonova and Maxim Karagyaur and Tolstoluzhinskaya Anastasiya and Uliana Dyachkova and Zhanna Akopyan and Vsevolod Tkachuk and Natalia Kalinina and Efimenko Anastasiya},
title = {Mesenchymal stromal cells facilitate resolution of pulmonary fibrosis by miR-29c and miR-129 intercellular transfer},
journal = {Experimental and Molecular Medicine},
year = {2023},
volume = {55},
publisher = {Springer Nature},
month = {jul},
url = {https://doi.org/10.1038/s12276-023-01017-w},
number = {7},
pages = {1399--1412},
doi = {10.1038/s12276-023-01017-w}
}
Cite this
MLA
Copy
Basalova, Nataliya, et al. “Mesenchymal stromal cells facilitate resolution of pulmonary fibrosis by miR-29c and miR-129 intercellular transfer.” Experimental and Molecular Medicine, vol. 55, no. 7, Jul. 2023, pp. 1399-1412. https://doi.org/10.1038/s12276-023-01017-w.