Open Access
Open access
Springer Nature
Oncogene
,  volume 40 ,  issue 42 ,  pages 6071-6080

PHF10 subunit of PBAF complex mediates transcriptional activation by MYC

Н. В. Сошникова 1, 2
, 
E V Tatarskiy 1
, 
V V Tatarskiy 3
, 
N.S Klimenko 4
, 
A A Shtil 3
, 
M. A. Nikiforov 5
, 
S. G. Georgieva 1, 6
1
 
2
 
3
 
4
 
5
 
6
 
Publication type: Journal Article
Publication date: 2021-08-31
Springer Nature
scimago Q1
wos Q1
SJR: 2.489
CiteScore: 15.4
Impact factor: 7.3
ISSN: 09509232, 14765594
Cancer Research
Molecular Biology
Genetics
Abstract
The PBAF complex, a member of SWI/SNF family of chromatin remodelers, plays an essential role in transcriptional regulation. We revealed a disease progression associated elevation of PHF10 subunit of PBAF in clinical melanoma samples. In melanoma cell lines, PHF10 interacts with MYC and facilitates the recruitment of PBAF complex to target gene promoters, therefore, augmenting MYC transcriptional activation of genes involved in the cell cycle progression. Depletion of either PHF10 or MYC induced G1 accumulation and a senescence-like phenotype. Our data identify PHF10 as a pro-oncogenic mechanism and an essential novel link between chromatin remodeling and MYC-dependent gene transcription.
Found 
Found 

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GOST |
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GOST Copy
Сошникова Н. В. et al. PHF10 subunit of PBAF complex mediates transcriptional activation by MYC // Oncogene. 2021. Vol. 40. No. 42. pp. 6071-6080.
GOST all authors (up to 50) Copy
Сошникова Н. В., Tatarskiy E. V., Tatarskiy V. V., Klimenko N., Shtil A. A., Nikiforov M. A., Georgieva S. G. PHF10 subunit of PBAF complex mediates transcriptional activation by MYC // Oncogene. 2021. Vol. 40. No. 42. pp. 6071-6080.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1038/s41388-021-01994-0
UR - https://doi.org/10.1038/s41388-021-01994-0
TI - PHF10 subunit of PBAF complex mediates transcriptional activation by MYC
T2 - Oncogene
AU - Сошникова, Н. В.
AU - Tatarskiy, E V
AU - Tatarskiy, V V
AU - Klimenko, N.S
AU - Shtil, A A
AU - Nikiforov, M. A.
AU - Georgieva, S. G.
PY - 2021
DA - 2021/08/31
PB - Springer Nature
SP - 6071-6080
IS - 42
VL - 40
PMID - 34465901
SN - 0950-9232
SN - 1476-5594
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2021_Сошникова,
author = {Н. В. Сошникова and E V Tatarskiy and V V Tatarskiy and N.S Klimenko and A A Shtil and M. A. Nikiforov and S. G. Georgieva},
title = {PHF10 subunit of PBAF complex mediates transcriptional activation by MYC},
journal = {Oncogene},
year = {2021},
volume = {40},
publisher = {Springer Nature},
month = {aug},
url = {https://doi.org/10.1038/s41388-021-01994-0},
number = {42},
pages = {6071--6080},
doi = {10.1038/s41388-021-01994-0}
}
MLA
Cite this
MLA Copy
Сошникова, Н. В., et al. “PHF10 subunit of PBAF complex mediates transcriptional activation by MYC.” Oncogene, vol. 40, no. 42, Aug. 2021, pp. 6071-6080. https://doi.org/10.1038/s41388-021-01994-0.