Open Access
The genomic landscape of Mexican Indigenous populations brings insights into the peopling of the Americas
Humberto García Ortiz
1
,
Francisco Barajas-Olmos
1
,
Cecilia Contreras Cubas
1
,
Miguel Ángel Cid Soto
1
,
Emilio J Córdova
1
,
Federico Centeno
1
,
Elvia Mendoza Caamal
1
,
Isabel Cicerón-Arellano
1
,
Marlen Flores Huacuja
1
,
Paulina Baca
1
,
Deborah A Bolnick
2
,
Meradeth Snow
3
,
Silvia Esperanza Flores-Martínez
4
,
Rocio Ortiz-Lopez
5
,
Austin W Reynolds
6
,
Antonio Blanchet
1
,
Mirna Morales Marín
1
,
Rafael Velázquez Cruz
1
,
Aleksandar Kostic
7
,
Carlos Galaviz-Hernandez
8
,
Alejandra Guadalupe García-Zapién
9
,
José Concepción Jiménez López
10
,
Guadalupe León Reyes
1
,
Eva Gabriela Salas Bautista
10
,
Blanca Patricia Lazalde-Ramos
11
,
Juan Luis Jiménez-Ruíz
1
,
Guadalupe Salas Martinez
1
,
Ramos-Madrigal J
12
,
Elaheh Mirzaeicheshmeh
1
,
Yolanda Saldaña Álvarez
1
,
María Del Carmen Abrahantes Pérez
1
,
Francisco Loeza Becerra
13
,
Raúl Mojica Espinosa
1
,
Federico Sanchez Quinto
1
,
Héctor Rangel Villalobos
14
,
Martha Sosa-Macías
8
,
José Sánchez-Corona
4
,
Augusto Rojas-Martínez
5
,
Angélica Martínez-Hernández
1
,
Lorena Orozco
1
5
Publication type: Journal Article
Publication date: 2021-10-12
scimago Q1
wos Q1
SJR: 4.761
CiteScore: 23.4
Impact factor: 15.7
ISSN: 20411723
PubMed ID:
34642312
General Chemistry
General Biochemistry, Genetics and Molecular Biology
General Physics and Astronomy
Abstract
The genetic makeup of Indigenous populations inhabiting Mexico has been strongly influenced by geography and demographic history. Here, we perform a genome-wide analysis of 716 newly genotyped individuals from 60 of the 68 recognized ethnic groups in Mexico. We show that the genetic structure of these populations is strongly influenced by geography, and our demographic reconstructions suggest a decline in the population size of all tested populations in the last 15–30 generations. We find evidence that Aridoamerican and Mesoamerican populations diverged roughly 4–9.9 ka, around the time when sedentary farming started in Mesoamerica. Comparisons with ancient genomes indicate that the Upward Sun River 1 (USR1) individual is an outgroup to Mexican/South American Indigenous populations, whereas Anzick-1 was more closely related to Mesoamerican/South American populations than to those from Aridoamerica, showing an even more complex history of divergence than recognized so far. Indigenous populations, including in those in Mexico are underrepresented in genetic studies. Here, the authors perform a population genetics study of indigenous peoples in Mexico to explore demographic histories of the region in the context of geography and cultural influences.
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Metrics
42
Total citations:
42
Citations from 2024:
17
(41.46%)
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GOST
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García Ortiz H. et al. The genomic landscape of Mexican Indigenous populations brings insights into the peopling of the Americas // Nature Communications. 2021. Vol. 12. No. 1. 5942
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García Ortiz H., Barajas-Olmos F., Contreras Cubas C., Cid Soto M. Á., Córdova E. J., Centeno F., Mendoza Caamal E., Cicerón-Arellano I., Flores Huacuja M., Baca P., Bolnick D. A., Snow M., Flores-Martínez S. E., Ortiz-Lopez R., Reynolds A. W., Blanchet A., Morales Marín M., Velázquez Cruz R., Kostic A., Galaviz-Hernandez C., García-Zapién A. G., Jiménez López J. C., León Reyes G., Salas Bautista E. G., Lazalde-Ramos B. P., Jiménez-Ruíz J. L., Salas Martinez G., J R., Mirzaeicheshmeh E., Saldaña Álvarez Y., Abrahantes Pérez M. D. C., Loeza Becerra F., Mojica Espinosa R., Sanchez Quinto F., Rangel Villalobos H., Sosa-Macías M., Sánchez-Corona J., Rojas-Martínez A., Martínez-Hernández A., Orozco L. The genomic landscape of Mexican Indigenous populations brings insights into the peopling of the Americas // Nature Communications. 2021. Vol. 12. No. 1. 5942
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TY - JOUR
DO - 10.1038/s41467-021-26188-w
UR - https://doi.org/10.1038/s41467-021-26188-w
TI - The genomic landscape of Mexican Indigenous populations brings insights into the peopling of the Americas
T2 - Nature Communications
AU - García Ortiz, Humberto
AU - Barajas-Olmos, Francisco
AU - Contreras Cubas, Cecilia
AU - Cid Soto, Miguel Ángel
AU - Córdova, Emilio J
AU - Centeno, Federico
AU - Mendoza Caamal, Elvia
AU - Cicerón-Arellano, Isabel
AU - Flores Huacuja, Marlen
AU - Baca, Paulina
AU - Bolnick, Deborah A
AU - Snow, Meradeth
AU - Flores-Martínez, Silvia Esperanza
AU - Ortiz-Lopez, Rocio
AU - Reynolds, Austin W
AU - Blanchet, Antonio
AU - Morales Marín, Mirna
AU - Velázquez Cruz, Rafael
AU - Kostic, Aleksandar
AU - Galaviz-Hernandez, Carlos
AU - García-Zapién, Alejandra Guadalupe
AU - Jiménez López, José Concepción
AU - León Reyes, Guadalupe
AU - Salas Bautista, Eva Gabriela
AU - Lazalde-Ramos, Blanca Patricia
AU - Jiménez-Ruíz, Juan Luis
AU - Salas Martinez, Guadalupe
AU - J, Ramos-Madrigal
AU - Mirzaeicheshmeh, Elaheh
AU - Saldaña Álvarez, Yolanda
AU - Abrahantes Pérez, María Del Carmen
AU - Loeza Becerra, Francisco
AU - Mojica Espinosa, Raúl
AU - Sanchez Quinto, Federico
AU - Rangel Villalobos, Héctor
AU - Sosa-Macías, Martha
AU - Sánchez-Corona, José
AU - Rojas-Martínez, Augusto
AU - Martínez-Hernández, Angélica
AU - Orozco, Lorena
PY - 2021
DA - 2021/10/12
PB - Springer Nature
IS - 1
VL - 12
PMID - 34642312
SN - 2041-1723
ER -
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@article{2021_García Ortiz,
author = {Humberto García Ortiz and Francisco Barajas-Olmos and Cecilia Contreras Cubas and Miguel Ángel Cid Soto and Emilio J Córdova and Federico Centeno and Elvia Mendoza Caamal and Isabel Cicerón-Arellano and Marlen Flores Huacuja and Paulina Baca and Deborah A Bolnick and Meradeth Snow and Silvia Esperanza Flores-Martínez and Rocio Ortiz-Lopez and Austin W Reynolds and Antonio Blanchet and Mirna Morales Marín and Rafael Velázquez Cruz and Aleksandar Kostic and Carlos Galaviz-Hernandez and Alejandra Guadalupe García-Zapién and José Concepción Jiménez López and Guadalupe León Reyes and Eva Gabriela Salas Bautista and Blanca Patricia Lazalde-Ramos and Juan Luis Jiménez-Ruíz and Guadalupe Salas Martinez and Ramos-Madrigal J and Elaheh Mirzaeicheshmeh and Yolanda Saldaña Álvarez and María Del Carmen Abrahantes Pérez and Francisco Loeza Becerra and Raúl Mojica Espinosa and Federico Sanchez Quinto and Héctor Rangel Villalobos and Martha Sosa-Macías and José Sánchez-Corona and Augusto Rojas-Martínez and Angélica Martínez-Hernández and Lorena Orozco},
title = {The genomic landscape of Mexican Indigenous populations brings insights into the peopling of the Americas},
journal = {Nature Communications},
year = {2021},
volume = {12},
publisher = {Springer Nature},
month = {oct},
url = {https://doi.org/10.1038/s41467-021-26188-w},
number = {1},
pages = {5942},
doi = {10.1038/s41467-021-26188-w}
}