Open Access

Nature Communications

, volume 13 , issue 1 , publication number 7346

Federated learning enables big data for rare cancer boundary detection

Sarthak Pati ^{1, 2, 3, 4}

Ujjwal Baid ^{1, 2, 3}

Brandon Edwards ⁵

Micah Sheller ⁵

Shih-Han Wang ⁵

G. Anthony Reina ⁵

Patrick Foley ⁵

Alexey Gruzdev ⁵

Deepthi Karkada ⁵

Christos Davatzikos ^{1, 2}

Chiharu Sako ^{1, 2}

Satyam Ghodasara ²

Michel Bilello ^{1, 2}

Suyash Mohan ^{1, 2}

Philipp Kickingereder ⁶

Gianluca Brugnara ⁶

Chandrakanth J Preetha ⁶

Felix Sahm ^{7, 8}

Klaus Maier-Hein ^{9, 10}

Maximilian Zenk ⁹

Martin Bendszus ⁶

Wolfgang Wick ^{7, 11}

Evan Calabrese ¹²

Jeffrey D. Rudie ¹²

Javier Villanueva-Meyer ¹²

Soonmee Cha ¹²

Madhura Ingalhalikar ¹³

Manali Jadhav ¹³

Umang Pandey ¹³

Jitender Saini ¹⁴

John W. Garrett ^{15, 16}

Matthew Larson ¹⁵

Robert Jeraj ^{15, 16}

Stuart Currie ¹⁷

Russell Frood ¹⁷

Kavi Fatania ¹⁷

Raymond Y Huang ¹⁸

Ken Chang ¹⁹

J. Capellades ²⁰

Jaume Capellades ²¹

Josep Puig ²²

Johannes Trenkler ²³

Josef Pichler ²⁴

Georg Necker ²³

Andreas Haunschmidt ²³

S. Meckel ^{23, 25}

GAURAV SHUKLA ^{1, 26}

Spencer Liem ²⁷

Gregory S Alexander ²⁸

Joseph Lombardo ^{27, 29}

Joshua Palmer ³⁰

Adam E. Flanders ³¹

Adam P. Dicker ²⁹

Haris I. Sair ^{32, 33}

Craig K. Jones ³³

Archana Venkataraman ³⁴

Meirui Jiang ³⁵

Tiffany Y So ³⁵

Cheng Chen ³⁵

PHENG-ANN HENG ³⁵

Qi Dou ³⁵

Michal Kozubek ³⁶

Filip Lux ³⁶

Jan Michálek ³⁶

Petr Matula ³⁶

Miloš Keřkovský ³⁷

Tereza Kopřivová ³⁷

Marek Dostál ^{37, 38}

Václav Vybíhal ³⁹

Michael A. Vogelbaum ⁴⁰

J. Ross Mitchell ^{41, 42}

Joaquim M. Farinhas ⁴³

Joseph A. Maldjian ⁴⁴

Chandan Ganesh Bangalore Yogananda ⁴⁴

Marco C. Pinho ⁴⁴

Divya Reddy ⁴⁴

James Holcomb ⁴⁴

Benjamin C. Wagner ⁴⁴

Benjamin M. Ellingson ^{45, 46}

Tim Cloughesy ⁴⁶

Catalina Raymond ⁴⁵

Talia Oughourlian ^{45, 47}

Akifumi Hagiwara ⁴⁷

Chencai Wang ⁴⁷

Minh-Son To ^{48, 49}

Sargam Bhardwaj ⁴⁸

Chee Chong ⁵⁰

Marc Agzarian ^{50, 51}

Alexandre X. Falcão ⁵²

Samuel B Martins ⁵³

Bernardo Corrêa de Almeida Teixeira ^{54, 55}

Flávia Sprenger ⁵⁵

David Menotti ⁵⁶

Diego R Lucio ⁵⁶

Pamela LaMontagne ⁵⁷

Daniel Marcus ⁵⁷

Benedikt Wiestler ^{58, 59}

Florian Kofler ^{58, 59, 60}

Ivan Ezhov ^{4, 59, 60}

Marie Metz ⁵⁸

Rajan Jain ^{61, 62}

Matthew Lee ⁶¹

Y. Lui ⁶¹

Richard McKinley ⁶³

Johannes Slotboom ⁶³

Piotr Radojewski ⁶³

Raphael Meier ⁶³

R Wiest ⁶³

Derrick Murcia ⁶⁴

Eric Fu ⁶⁴

Rourke Haas ⁶⁴

John Thompson ⁶⁴

D. Ryan Ormond ⁶⁴

Chaitra Badve ⁶⁵

Andrew E. Sloan ^{66, 67, 68}

Vachan Vadmal ⁶⁸

Kristin A. Waite ⁶⁹

Rivka R. Colen ^{70, 71}

Linmin Pei ⁷²

Murat Ak ⁷⁰

Ashok Srinivasan ⁷³

J. R. BAPURAJ ⁷³

Arvind Rao ⁷⁴

Nicholas Wang ⁷⁴

Yoshiaki Ota ⁷³

Toshio Moritani ⁷³

Sevcan Turk ⁷³

Joonsang Lee ⁷⁴

Snehal Prabhudesai ⁷⁴

Fanny Morón ⁷⁵

J. Mandel ⁵¹

Konstantinos Kamnitsas ^{76, 77}

Ben Glocker ⁷⁶

Luke Dixon ⁷⁸

Matt Williams ⁷⁹

Peter Zampakis ⁸⁰

Vasileios Panagiotopoulos ⁸¹

Panagiotis Tsiganos ⁸²

SOTIRIS ALEXIOU ⁸³

Ilias Haliassos ⁸⁴

Evangelia I. Zacharaki ⁸³

Shagufta Ishtiaque ⁸³

Christina Kalogeropoulou ⁸⁰

Dimitrios M Kardamakis ⁸⁵

Yoon Seong Choi ⁸⁶

Seung-Koo Lee ⁸⁶

Jong Wun Chang ⁸⁶

Sung Yul Ahn ⁸⁶

Bing Luo ⁸⁷

Laila M. Poisson ⁸⁸

Ning Wen ^{87, 89}

Pallavi Tiwari ⁹⁰

Ruchika Verma ^{42, 90}

Rohan Bareja ⁹⁰

Ipsa Yadav ⁹⁰

Jonathan Chen ⁹⁰

Neeraj Kumar ^{41, 42}

Marion Smits ⁹¹

Sebastian R Van Der Voort ⁹¹

Ahmed Alafandi ⁹¹

Fatih Incekara ^{91, 92}

Maarten M J Wijnenga ⁹³

Georgios Kapsas ⁹¹

Renske Gahrmann ⁹¹

Joost W. Schouten ⁹²

H. J. Dubbink ⁹⁴

Arnaud J P E Vincent ⁹²

Martin J. Van den Bent ⁹³

P J French ⁹³

Stefan Klein ⁹⁵

Yading Yuan ⁹⁶

Sonam Sharma ⁹⁶

Tzu Chi Tseng ⁹⁶

Saba Adabi ⁹⁶

Simone P Niclou ⁹⁷

Olivier Keunen ⁹⁸

Ann Christin Hau ^{97, 99}

Martin Vallières ^{100, 101}

David Fortin ^{101, 102}

Martin Lepage ^{101, 103}

Bennett A. Landman ¹⁰⁴

Karthik Ramadass ¹⁰⁴

Kaiwen Xu ¹⁰⁵

Silky Chotai ¹⁰⁶

Lola B. Chambless ¹⁰⁶

Akshitkumar Mistry ¹⁰⁶

Reid C. Thompson ¹⁰⁶

Y. Gusev ¹⁰⁷

Bhuvaneshwar K ¹⁰⁷

Anousheh Sayah ¹⁰⁸

Camelia Bencheqroun ¹⁰⁷

Anas Belouali ¹⁰⁷

Subha Madhavan ¹⁰⁷

Thomas C. Booth ^{109, 110}

Alysha Chelliah ¹⁰⁹

Marc Modat ¹⁰⁹

Haris Shuaib ^{111, 112}

Carmen Dragos ¹¹¹

Aly Abayazeed ¹¹³

Kenneth Kolodziej ¹¹³

Michael Hill ¹¹³

Ahmed Abbassy ¹¹⁴

Shady Gamal ¹¹⁴

Mahmoud Mekhaimar ¹¹⁴

Mohamed Qayati ¹¹⁴

Mauricio Reyes ¹¹⁵

Ji Eun Park ¹¹⁶

Jihye Yun ¹¹⁶

Ho Sung Kim ¹¹⁶

Abhishek Mahajan ¹¹⁷

Mark Muzi ¹¹⁸

Sean Benson ¹¹⁹

Regina G.H. Beets-Tan ^{120, 121}

Jonas Teuwen ¹¹⁹

Alejandro Herrera Trujillo ^{122, 123}

MARIA TRUJILLO ¹²³

William Escobar ^{122, 123}

Ana Abello ¹²³

JOSE M. BERNAL ^{123, 124}

Jhon Gómez ¹²³

Joseph Choi ¹²⁵

Stephen Baek ¹²⁶

Yusung Kim ¹²⁷

Heba Ismael ¹²⁷

Bryan G. Allen ¹²⁷

John M. Buatti ¹²⁷

Aikaterini Kotrotsou ¹²⁸

Hongwei Li ¹²⁹

Tobias Weiss ¹³⁰

M Weller ¹³⁰

Andrea Bink ¹³¹

Bertrand Pouymayou ¹³¹

Hassan F Shaykh ¹³²

Joel H Saltz ¹³³

Prateek Prasanna ¹³³

Sampurna Shrestha ¹³³

Kartik M Mani ^{133, 134}

David Payne ¹³⁵

Tahsin Kurc ^{133, 136}

Enrique Pelaez ¹³⁷

Heydy Franco Maldonado ¹³⁸

Francis Loayza ¹³⁷

Sebastian Quevedo ¹³⁹

Pamela Guevara ¹⁴⁰

Esteban Torche ¹⁴⁰

Cristobal Mendoza ¹⁴⁰

Franco Vera ¹⁴⁰

Elvis Ríos ¹⁴⁰

Eduardo López ¹⁴⁰

Sergio A. Velastin ¹⁴¹

Godwin Ogbole ¹⁴²

Mayowa Soneye ¹⁴²

Dotun Oyekunle ¹⁴²

Olubunmi Odafe Oyibotha ¹⁴³

Babatunde Osobu ¹⁴²

Mustapha Shuaibu ¹⁴⁴

Adeleye Dorcas ¹⁴⁵

Farouk Dako ^{2, 146}

Amber L. Simpson ^{112, 147}

Mohammad Hamghalam ^{147, 148}

Jacob J Peoples ¹⁴⁷

Ricky Hu ¹⁴⁷

Anh Tran ¹⁴⁷

Danielle Cutler ¹⁴⁹

Fabio Ynoe de Moraes ¹⁵⁰

MICHAEL A. BOSS ¹⁵¹

James Gimpel ¹⁵¹

Deepak Kattil Veettil ¹⁵¹

Kendall Schmidt ¹⁵²

Brian Bialecki ¹⁵²

Sailaja Marella ¹⁵¹

Cynthia Price ¹⁵¹

Lisa Cimino ¹⁵¹

Charles Apgar ¹⁵¹

Prashant Shah ⁵

Bjoern Menze ^{4, 129}

Jill S. Barnholtz-Sloan ^{69, 153}

Jason Martin ⁵

Spyridon Bakas ^{1, 2, 3}

Hide authors affiliations Show authors affiliations: 153 affiliations

Center for Biomedical Image Computing and Analytics (CBICA), University of Pennsylvania, Philadelphia, USA |

Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA |

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA |

⁴

Department of Informatics, Technical University of Munich, Munich, Germany |

⁵

Intel Corporation, Santa Clara, USA |

⁶

Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany |

⁷

Clinical Cooperation Unit Neuropathology, German Cancer Consortium (DKTK) within the German Cancer Research Center (DKFZ), Heidelberg, Germany |

⁸

Department of Neuropathology, Heidelberg University Hospital, Heidelberg, Germany |

⁹

Division of Medical Image Computing, German Cancer Research Center, Heidelberg, Germany |

¹⁰

Pattern Analysis and Learning Group, Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany |

¹¹

Neurology Clinic, Heidelberg University Hospital, Heidelberg, Germany |

¹²

Department of Radiology & Biomedical Imaging, University of California San Francisco, San Francisco, USA |

¹³

Symbiosis Center for Medical Image Analysis, Symbiosis International University, Pune, India |

¹⁴

Department of Neuroimaging and Interventional Radiology, National Institute of mental health and neurosciences, Bangalore, India |

¹⁵

Department of Radiology, School of Medicine and Public Health, University of Wisconsin, Madison, USA |

¹⁶

Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin, Madison, USA |

¹⁷

Leeds Teaching Hospitals Trust, Department of Radiology, Leeds, UK |

¹⁸

Department of Radiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA

Harvard University

Brigham and Women's Hospital

¹⁹

Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, USA |

²⁰

Catalan Institute Of Oncology, Badalona, Spain |

²¹

Consorci MAR Parc de Salut de Barcelona, Catalonia, Spain |

²²

Department of Radiology (IDI), Girona Biomedical Research Institute (IdIBGi), Josep Trueta University Hospital, Girona, Spain |

²³

Institute of Neuroradiology, Neuromed Campus (NMC), Kepler University Hospital Linz, Linz, Austria |

²⁴

Department of Neurooncology, Neuromed Campus (NMC), Kepler University Hospital Linz, Linz, Austria |

²⁵

Institute of Diagnostic and Interventional Neuroradiology, RKH Klinikum Ludwigsburg, Ludwigsburg, Germany |

²⁶

Department of Radiation Oncology, Christiana Care Health System, Philadelphia, USA |

²⁷

Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, USA |

²⁸

Department of Radiation Oncology, University of Maryland, Baltimore, USA |

²⁹

Department of Radiation Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, USA |

³⁰

Department of Radiation Oncology, The James Cancer Hospital and Solove Research Institute, The Ohio State University Comprehensive Cancer Center, Columbus, USA |

³¹

Department of Radiology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, USA |

³²

The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, USA |

³³

The Malone Center for Engineering in Healthcare, The Whiting School of Engineering, Johns Hopkins University, Baltimore, USA |

³⁴

Department of Electrical and Computer Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, USA |

³⁵

the Chinese University of Hong Kong, Hong Kong, China |

³⁶

Centre for Biomedical Image Analysis, Faculty of Informatics, Masaryk University, Brno, Czech republic |

³⁷

Department of Radiology and Nuclear Medicine, Faculty of Medicine, Masaryk University, Brno and University Hospital Brno, Brno, Czech Republic

Masaryk University

University Hospital Brno

³⁸

Department of Biophysics, Faculty of Medicine, Masaryk University, Brno, Czech Republic |

³⁹

Department of Neurosurgery, Faculty of Medicine, Masaryk University, Brno, and University Hospital and Czech Republic, Brno, Czech Republic

Masaryk University

University Hospital Brno

⁴⁰

Department of Neuro Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, USA |

⁴¹

university of alberta, edmonton, Canada |

⁴²

Alberta Machine Intelligence Institute, Edmonton, Canada |

⁴³

Department of Radiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, USA |

⁴⁴

University of Texas southwestern Medical Center, Dallas, USA |

⁴⁵

UCLA Brain Tumor Imaging Laboratory (BTIL), Center for Computer Vision and Imaging Biomarkers, Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, USA |

⁴⁶

UCLA Neuro-Oncology Program, Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, USA |

⁴⁷

Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, USA |

⁴⁸

College of Medicine and Public Health, Flinders University, Bedford Park, Australia |

⁴⁹

Division of Surgery and Perioperative Medicine, Flinders Medical Centre, Bedford Park, Australia |

⁵⁰

South Australia Medical Imaging, Flinders Medical Centre, Bedford Park, Australia |

⁵¹

Department of Neurology, Baylor College of Medicine, Houston, USA |

⁵²

Institute of Computing, University of Campinas, Campinas, Brazil |

⁵³

Federal Institute of São Paulo, Campinas, Brazil |

⁵⁴

Instituto de Neurologia de Curitiba, Curitiba, Brazil |

⁵⁵

Department of Radiology, Hospital de Clínicas da Universidade Federal Do Paraná, Curitiba, Paraná, Brazil |

⁵⁶

Department of Informatics, Universidade Federal do Paraná, Curitiba, Paraná, Brazil |

⁵⁷

Department of Radiology, Washington University in St. Louis, St. Louis, USA |

⁵⁸

Department of Diagnostic and Interventional Neuroradiology, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany

Technical University of Munich

Rechts der Isar Hospital

⁵⁹

TranslaTUM (Zentralinstitut für translationale Krebsforschung der Technischen Universität München), Klinikum rechts der Isar, Munich, Germany

Ludwig Maximilian University of Munich

Rechts der Isar Hospital

München Klinik

⁶⁰

Image-Based Biomedical Modeling, Department of Informatics, Technical University of Munich, Munich, Germany |

⁶¹

Department of Radiology, NYU Grossman School of Medicine, New York, USA |

⁶²

Department of Neurosurgery, NYU Grossman School of Medicine, New York, USA |

⁶³

Support Center for Advanced Neuroimaging, University Institute of Diagnostic and Interventional Neuroradiology, University Hospital Bern, Inselspital, University of Bern, Bern, Switzerland |

⁶⁴

Department of Neurosurgery, Anschutz Medical Campus, University of Colorado, Aurora, USA |

⁶⁵

Department of Radiology, University Hospitals Cleveland, Cleveland, USA |

⁶⁶

Department of Neurological Surgery, University Hospitals-Seidman Cancer Center, Cleveland, USA |

⁶⁷

Case Comprehensive Cancer Center, Cleveland, USA |

⁶⁸

Department of Neurosurgery, Case Western Reserve University School of Medicine, Cleveland, USA |

⁶⁹

National Cancer Institute, National Institute of Health, Division of Cancer Epidemiology and Genetics, Bethesda, USA |

⁷⁰

Department of Radiology, Neuroradiology Division, University of Pittsburgh, Pittsburgh, USA |

⁷¹

Department of Diagnostic Radiology, University of Texas MD Anderson Cancer Center, Houston, USA |

⁷²

University of Pittsburgh Medical Center, Pittsburgh, USA |

⁷³

Department of Neuroradiology, University of Michigan, Ann Arbor, USA |

⁷⁴

Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, USA |

⁷⁵

Department of Radiology, Baylor College of Medicine, Houston, USA |

⁷⁶

Department of computing, Imperial College London, London, UK |

⁷⁷

Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, UK |

⁷⁸

Department of Radiology, Imperial College NHS Healthcare Trust, London, UK |

⁷⁹

Computational Oncology Group, Institute for Global Health Innovation, Imperial College London, London, UK |

⁸⁰

Department of NeuroRadiology, University of Patras, Patras, Greece |

⁸¹

Department of Neurosurgery, University of Patras, Patras, Greece |

⁸²

Clinical Radiology Laboratory, Department of Medicine, University of Patras, Patras, Greece |

⁸³

Department of Electrical and Computer Engineering, University of Patras, Patras, Greece |

⁸⁴

Department of Neuro-Oncology, University of Patras, Patras, Greece |

⁸⁵

Department of Radiation Oncology, University of Patras, Patras, Greece |

⁸⁶

Yonsei University College of Medicine, Seoul, Korea |

⁸⁷

Department of Radiation Oncology, Henry Ford Health System, Detroit, USA |

⁸⁸

Public Health Sciences, Henry Ford Health System, Detroit, USA |

⁸⁹

SJTU-Ruijin-UIH Institute for Medical Imaging Technology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China |

⁹⁰

Case Western Reserve University, Cleveland, USA |

⁹¹

Department of Radiology and Nuclear Medicine, Erasmus MC University Medical Centre Rotterdam, Rotterdam, Netherlands |

⁹²

Department of Neurosurgery, Brain Tumor Center, Erasmus MC University Medical Centre Rotterdam, Rotterdam, Netherlands |

⁹³

Department of Neurology, Brain Tumor Center, Erasmus MC Cancer Institute, Rotterdam, Netherlands |

⁹⁴

Department of Pathology, Brain Tumor Center, Erasmus MC Cancer Institute, Rotterdam, Netherlands |

⁹⁵

Biomedical Imaging Group Rotterdam, Department of Radiology and Nuclear Medicine, Erasmus MC University Medical Centre Rotterdam, Rotterdam, Netherlands |

⁹⁶

Department of Radiation Oncology, Icahn School of Medicine At Mount Sinai, New York, USA |

⁹⁷

NORLUX Neuro-Oncology Laboratory, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg, Luxembourg |

⁹⁸

Translation Radiomics, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg, Luxembourg |

⁹⁹

Luxembourg Center of Neuropathology, Laboratoire National De Santé, Luxembourg, Luxembourg |

¹⁰⁰

Department of Computer Science, Université de Sherbrooke, Sherbrooke, Canada |

¹⁰¹

Centre de Recherche du Centre Hospitalière Universitaire de Sherbrooke, Sherbrooke, Canada |

¹⁰²

Division of Neurosurgery and Neuro-Oncology, Faculty of Medicine and Health Science, Université de Sherbrooke, Sherbrooke, Canada |

¹⁰³

Department of Nuclear Medicine and Radiobiology, Sherbrooke Molecular Imaging Centre, Université de Sherbrooke, Sherbrooke, Canada |

¹⁰⁴

Electrical and Computer Engineering, Vanderbilt University, Nashville, USA |

¹⁰⁵

Department of Computer Science, Vanderbilt University, Nashville, USA |

¹⁰⁶

Department of Neurosurgery, Vanderbilt University Medical Center, Nashville, USA |

¹⁰⁷

Innovation Center for Biomedical Informatics (ICBI), Georgetown University, Washington, USA |

¹⁰⁸

Division of Neuroradiology & Neurointerventional Radiology, Department of Radiology, MedStar Georgetown University Hospital, Washington, USA |

¹⁰⁹

School of Biomedical Engineering & Imaging Sciences, King’s College London, London, UK |

¹¹⁰

Department of Neuroradiology, Ruskin Wing, King’s College Hospital NHS Foundation Trust, London, UK |

¹¹¹

Stoke Mandeville Hospital, Aylesbury, UK |

¹¹²

Department of BioMedical and Molecular Sciences, Queen’s University, Kingston, Canada |

¹¹³

Neosoma Inc., Groton, USA |

¹¹⁴

University of Cairo School of Medicine, Giza, Egypt |

¹¹⁵

University Of Bern, Bern, Switzerland |

¹¹⁶

Department of Radiology, ASAN Medical Center, Seoul, South Korea |

¹¹⁷

The Clatterbridge Cancer Centre NHS Foundation Trust Pembroke Place, Liverpool, UK |

¹¹⁸

Department of Radiology, University of Washington, Seattle, USA |

¹¹⁹

Netherlands Cancer Institute, Amsterdam, NETHERLANDS |

¹²⁰

Department of Radiology, Netherlands Cancer Institute, Amsterdam, Netherlands |

¹²¹

GROW School of Oncology and Developmental Biology, Maastricht, Netherlands |

¹²²

Clínica Imbanaco Grupo Quirón Salud, Cali, Colombia |

¹²³

Universidad Del Valle, Cali, Colombia |

¹²⁴

The University of Edinburgh, Edinburgh, UK |

¹²⁵

Department of Industrial and Systems Engineering, University of Iowa, Iowa, USA |

¹²⁶

Department of Industrial and Systems Engineering, Department of Radiation Oncology, University of Iowa, Iowa City, USA |

¹²⁷

Department of Radiation Oncology, University of Iowa, Iowa City, USA |

¹²⁸

MD Anderson Cancer Center, University of Texas, Houston, USA |

¹²⁹

Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland |

¹³⁰

Department of Neurology, Clinical Neuroscience Center, University Hospital Zurich and University of Zurich, Zurich, Switzerland |

¹³¹

Department of Neuroradiology, Clinical Neuroscience Center, University Hospital Zurich and University of Zurich, Zurich, Switzerland |

¹³²

University of Alabama in Birmingham, Birmingham, USA |

¹³³

Department of Biomedical Informatics, Stony Brook University, Stony Brook, New York, USA |

¹³⁴

Department of Radiation Oncology, Stony Brook University, Stony Brook, USA |

¹³⁵

Department of Radiology, Stony Brook University, Stony Brook, USA |

¹³⁶

Scientific Data Group, Oak Ridge National Laboratory, Oak Ridge, USA |

¹³⁷

Escuela Superior Politecnica del Litoral, Guayaquil, Ecuador |

¹³⁸

Sociedad de Lucha Contral el Cancer - SOLCA, Guayaquil Ecuador, Guayaquil, Ecuador |

¹³⁹

Universidad Católica de Cuenca, Cuenca, Ecuador |

¹⁴⁰

Universidad de Concepción, Concepción, Chile |

¹⁴¹

School of electronic engineering and computer science, Queen Mary University of London, London, UK |

¹⁴²

Department of Radiology, University College Hospital Ibadan, Oyo, Nigeria |

¹⁴³

Clinix Healthcare, Lagos, Lagos, Nigeria |

¹⁴⁴

Department of Radiology, Muhammad Abdullahi Wase Teaching Hospital, Kano, Nigeria |

¹⁴⁵

Department of Radiology, Obafemi Awolowo University Ile-Ife, Ile-Ife, Nigeria |

¹⁴⁶

Center for Global Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA |

¹⁴⁷

School of Computing, Queen’s University, Kingston, Canada |

¹⁴⁸

Department of Electrical Engineering, Qazvin Branch, Islamic Azad University, Qazvin, Iran |

¹⁴⁹

The Faculty of Arts & Sciences, Queen’s University, Kingston, Canada |

¹⁵⁰

Department of Oncology, Queen’s University, Kingston, Canada |

¹⁵¹

Center for Research and Innovation, American College of Radiology, Philadelphia, USA |

¹⁵²

Data Science Institute, American College of Radiology, Reston, USA |

¹⁵³

Center for Biomedical Informatics and Information Technology, National Cancer Institute (NCI), National Institute of Health, Bethesda, USA |

Publication type: Journal Article

Publication date: 2022-12-05

Springer Nature

Nature Communications

scimago Q1

wos Q1

SJR: 4.761

CiteScore: 23.4

Impact factor: 15.7

ISSN: 20411723

DOI: 10.1038/s41467-022-33407-5

Copy DOI

PubMed ID: 36470898

General Chemistry

General Biochemistry, Genetics and Molecular Biology

Multidisciplinary

General Physics and Astronomy

Abstract

Although machine learning (ML) has shown promise across disciplines, out-of-sample generalizability is concerning. This is currently addressed by sharing multi-site data, but such centralization is challenging/infeasible to scale due to various limitations. Federated ML (FL) provides an alternative paradigm for accurate and generalizable ML, by only sharing numerical model updates. Here we present the largest FL study to-date, involving data from 71 sites across 6 continents, to generate an automatic tumor boundary detector for the rare disease of glioblastoma, reporting the largest such dataset in the literature (n = 6, 314). We demonstrate a 33% delineation improvement for the surgically targetable tumor, and 23% for the complete tumor extent, over a publicly trained model. We anticipate our study to: 1) enable more healthcare studies informed by large diverse data, ensuring meaningful results for rare diseases and underrepresented populations, 2) facilitate further analyses for glioblastoma by releasing our consensus model, and 3) demonstrate the FL effectiveness at such scale and task-complexity as a paradigm shift for multi-site collaborations, alleviating the need for data-sharing.

Found

1 citation

Bujotzek Markus

3 publications, 14 citations

h-index: 3

German Cancer Research Center

Heidelberg University

1 citation

Ozair Ahmad

171 publications, 2 352 citations, 345 reviews

h-index: 18

University of Oxford

University of Maryland, Baltimore

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Lecture Notes in Computer Science	Lecture Notes in Computer Science, 4, 1.61% Lecture Notes in Computer Science 4 publications, 1.61%
Medical Image Analysis	Medical Image Analysis, 4, 1.61% Medical Image Analysis 4 publications, 1.61%
IEEE Transactions on Medical Imaging	IEEE Transactions on Medical Imaging, 3, 1.2% IEEE Transactions on Medical Imaging 3 publications, 1.2%
Diagnostics	Diagnostics, 3, 1.2% Diagnostics 3 publications, 1.2%
Computers in Biology and Medicine	Computers in Biology and Medicine, 3, 1.2% Computers in Biology and Medicine 3 publications, 1.2%
IEEE Internet of Things Journal	IEEE Internet of Things Journal, 3, 1.2% IEEE Internet of Things Journal 3 publications, 1.2%
Patterns	Patterns, 3, 1.2% Patterns 3 publications, 1.2%
The Lancet Oncology	The Lancet Oncology, 3, 1.2% The Lancet Oncology 3 publications, 1.2%
Academic Radiology	Academic Radiology, 2, 0.8% Academic Radiology 2 publications, 0.8%
Neuroradiology	Neuroradiology, 2, 0.8% Neuroradiology 2 publications, 0.8%
Clinical Radiology	Clinical Radiology, 2, 0.8% Clinical Radiology 2 publications, 0.8%
Expert Systems with Applications	Expert Systems with Applications, 2, 0.8% Expert Systems with Applications 2 publications, 0.8%
npj Precision Oncology	npj Precision Oncology, 2, 0.8% npj Precision Oncology 2 publications, 0.8%
Radiotherapy and Oncology	Radiotherapy and Oncology, 2, 0.8% Radiotherapy and Oncology 2 publications, 0.8%
Cancer Discovery	Cancer Discovery, 2, 0.8% Cancer Discovery 2 publications, 0.8%
IEEE Access	IEEE Access, 2, 0.8% IEEE Access 2 publications, 0.8%
Journal of the American Medical Informatics Association : JAMIA	Journal of the American Medical Informatics Association : JAMIA, 2, 0.8% Journal of the American Medical Informatics Association : JAMIA 2 publications, 0.8%
Machine Learning: Science and Technology	Machine Learning: Science and Technology, 2, 0.8% Machine Learning: Science and Technology 2 publications, 0.8%
IEEE Transactions on Pattern Analysis and Machine Intelligence	IEEE Transactions on Pattern Analysis and Machine Intelligence, 2, 0.8% IEEE Transactions on Pattern Analysis and Machine Intelligence 2 publications, 0.8%
Lecture Notes in Networks and Systems	Lecture Notes in Networks and Systems, 2, 0.8% Lecture Notes in Networks and Systems 2 publications, 0.8%
Eng—Advances in Engineering	Eng—Advances in Engineering, 2, 0.8% Eng—Advances in Engineering 2 publications, 0.8%
American Journal of Neuroradiology	American Journal of Neuroradiology, 2, 0.8% American Journal of Neuroradiology 2 publications, 0.8%
Investigative Radiology	Investigative Radiology, 1, 0.4% Investigative Radiology 1 publication, 0.4%
	1 2 3 4 5 6

Publishers

	10 20 30 40 50 60
Springer Nature	Springer Nature, 60, 24.1% Springer Nature 60 publications, 24.1%
Elsevier	Elsevier, 55, 22.09% Elsevier 55 publications, 22.09%
Institute of Electrical and Electronics Engineers (IEEE)	Institute of Electrical and Electronics Engineers (IEEE), 41, 16.47% Institute of Electrical and Electronics Engineers (IEEE) 41 publications, 16.47%
MDPI	MDPI, 17, 6.83% MDPI 17 publications, 6.83%
Oxford University Press	Oxford University Press, 12, 4.82% Oxford University Press 12 publications, 4.82%
Frontiers Media S.A.	Frontiers Media S.A., 8, 3.21% Frontiers Media S.A. 8 publications, 3.21%
Wiley	Wiley, 7, 2.81% Wiley 7 publications, 2.81%
Cold Spring Harbor Laboratory	Cold Spring Harbor Laboratory, 7, 2.81% Cold Spring Harbor Laboratory 7 publications, 2.81%
Radiological Society of North America (RSNA)	Radiological Society of North America (RSNA), 6, 2.41% Radiological Society of North America (RSNA) 6 publications, 2.41%
JMIR Publications	JMIR Publications, 4, 1.61% JMIR Publications 4 publications, 1.61%
SAGE	SAGE, 4, 1.61% SAGE 4 publications, 1.61%
American Association for Cancer Research (AACR)	American Association for Cancer Research (AACR), 3, 1.2% American Association for Cancer Research (AACR) 3 publications, 1.2%
IOP Publishing	IOP Publishing, 3, 1.2% IOP Publishing 3 publications, 1.2%
Baishideng Publishing Group	Baishideng Publishing Group, 3, 1.2% Baishideng Publishing Group 3 publications, 1.2%
Ovid Technologies (Wolters Kluwer Health)	Ovid Technologies (Wolters Kluwer Health), 2, 0.8% Ovid Technologies (Wolters Kluwer Health) 2 publications, 0.8%
Association for Computing Machinery (ACM)	Association for Computing Machinery (ACM), 2, 0.8% Association for Computing Machinery (ACM) 2 publications, 0.8%
SPIE-Intl Soc Optical Eng	SPIE-Intl Soc Optical Eng, 2, 0.8% SPIE-Intl Soc Optical Eng 2 publications, 0.8%
American Society of Clinical Oncology (ASCO)	American Society of Clinical Oncology (ASCO), 2, 0.8% American Society of Clinical Oncology (ASCO) 2 publications, 0.8%
Massachusetts Medical Society	Massachusetts Medical Society, 1, 0.4% Massachusetts Medical Society 1 publication, 0.4%
Taylor & Francis	Taylor & Francis, 1, 0.4% Taylor & Francis 1 publication, 0.4%
OAE Publishing Inc.	OAE Publishing Inc., 1, 0.4% OAE Publishing Inc. 1 publication, 0.4%
Annual Reviews	Annual Reviews, 1, 0.4% Annual Reviews 1 publication, 0.4%
BMJ	BMJ, 1, 0.4% BMJ 1 publication, 0.4%
World Scientific	World Scientific, 1, 0.4% World Scientific 1 publication, 0.4%
Cambridge University Press	Cambridge University Press, 1, 0.4% Cambridge University Press 1 publication, 0.4%
American Society of Neuoradiology	American Society of Neuoradiology, 1, 0.4% American Society of Neuoradiology 1 publication, 0.4%
American Society of Neuroradiology (ASNR)	American Society of Neuroradiology (ASNR), 1, 0.4% American Society of Neuroradiology (ASNR) 1 publication, 0.4%
	10 20 30 40 50 60

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249

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GOST Copy

Pati S. et al. Federated learning enables big data for rare cancer boundary detection // Nature Communications. 2022. Vol. 13. No. 1. 7346

GOST all authors (up to 50) Copy

Pati S. et al. Federated learning enables big data for rare cancer boundary detection // Nature Communications. 2022. Vol. 13. No. 1. 7346

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BibTex (up to 50 authors) Copy

@article{2022_Pati,

author = {Sarthak Pati and Ujjwal Baid and Brandon Edwards and Micah Sheller and Shih-Han Wang and G. Anthony Reina and Patrick Foley and Alexey Gruzdev and Deepthi Karkada and Christos Davatzikos and Chiharu Sako and Satyam Ghodasara and Michel Bilello and Suyash Mohan and Philipp Kickingereder and Gianluca Brugnara and Chandrakanth J Preetha and Felix Sahm and Klaus Maier-Hein and Maximilian Zenk and Martin Bendszus and Wolfgang Wick and Evan Calabrese and Jeffrey D. Rudie and Javier Villanueva-Meyer and Soonmee Cha and Madhura Ingalhalikar and Manali Jadhav and Umang Pandey and Jitender Saini and John W. Garrett and Matthew Larson and Robert Jeraj and Stuart Currie and Russell Frood and Kavi Fatania and Raymond Y Huang and Ken Chang and J. Capellades and Jaume Capellades and Josep Puig and Johannes Trenkler and Josef Pichler and Georg Necker and Andreas Haunschmidt and S. Meckel and GAURAV SHUKLA and Spencer Liem and Gregory S Alexander and Joseph Lombardo and others},

title = {Federated learning enables big data for rare cancer boundary detection},

journal = {Nature Communications},

year = {2022},

volume = {13},

publisher = {Springer Nature},

month = {dec},

url = {https://doi.org/10.1038/s41467-022-33407-5},

number = {1},

pages = {7346},

doi = {10.1038/s41467-022-33407-5}

}

Publisher

Springer Nature

Journal

Nature Communications

scimago Q1

wos Q1

SJR

4.761

CiteScore

23.4

Impact factor

15.7

ISSN

20411723 (Print, Electronic)

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