Universidad Católica de Cuenca

Roman J., Hernandez I., Sanchez M., Perez N., Andrade S., Cepeda V., Chedraui P., Flores M., Galarza C., Guerron M., Munoz M., Ortega H., Ortiz-Prado E., Perez J., Perez F., et. al.

ObjectiveTo describe the sexual practices and behaviour towards HIV infection among Ecuadorian university students.MethodsThis was a cross-sectional, descriptive study carried out between February 2019 and August 2020 among university students from all over the country. Students aged 18 years and older of each participating institution were contacted by an official email account and invited to fill out a survey through Google Forms.ResultsData from a total of 5677 sexually active participants were analysed. The majority were female (57.1%), 48.7% corresponded to the age range 18–20 years and nearly half studied in the field of health. Only 28.5% (n=1612) mentioned having ever been tested for HIV at least once. Regarding sexual behaviour, the vast majority reported having only one partner in the last 2 months. Condom use during the ‘last’ sexual contact was significantly lower in the never tested group (33.5% vs 43.3%, p<0.0001, respectively). Having a higher number of ever or current sexual partners (OR 0.94, 95% CI 0.78 to 1.13) and not using a condom (OR 0.73, 95% CI 0.64 to 0.82) were significantly related to having an HIV test performed. More than half of the participants indicated that they took the HIV test as part of their routine control, and nearly half mentioned not taking it because they felt sure they were free of HIV.ConclusionsBehaviour towards testing for HIV in university students was related to their risky sexual practices and behaviour. Prevention campaigns focused on the general population as well as at-risk populations, including university students, are needed to curb the escalating incidence of HIV in Ecuador.

Garcia-Lopez A., Abdalah L., Salgado O.J., Vachharajani T.J.

Introduction: Nicaragua is a Central American country with a high prevalence of patients with chronic kidney disease, particularly among young men. This is largely attributable to Mesoamerican nephropathy, a form of interstitial nephritis that predominantly affects young agricultural workers. While the majority of patients have access to chronic dialysis programs, a very small number have an option of receiving a renal transplant. Consequently, they must spend years on hemodialysis (HD), where the vascular access issue is of vital importance for their survival. Given that prosthetic arteriovenous grafts (AVG) are expensive devices with a lower cost-benefit ratio, limited availability within the health system and are unaffordable for the majority of patients, it is crucial to perform autogenic arteriovenous fistula (AVF) whenever possible. Patients and methods: This paper presents a 4-year period review (2020–2023) of a single-center vascular access program that optimizes vasculature utilization of each patient for creation of AFV and describes the surgical revision techniques used to prolong the patency of vascular accesses. Results: The autogenic vascular access program has resulted in more than 80% of prevalent patients undergoing HD at our center being hemodialyzed through an autogenic AVF by the end of 2023. Conclusions: It can be concluded that it is possible to significantly increase the proportion of autogenic vascular accesses in each center by optimizing the patient’s own vasculature. This approach has the potential to reduce morbidity and costs, particularly in low-income countries.

Reivan Ortiz G.G., Elizalde B., Tapia C., Granero R.

Background-objectives: Multiple dynamic interacting factors contribute to the presence and progression of eating disorders (ED). Empirical research has provided mixed findings regarding the mechanisms explaining the contribution of body mass index (BMI) to the diverse ED endophenotypes. The present study aims to evaluate the underlying processes (direct and indirect effects) contributing to BMI and ED severity, considering the contribution of multiple neuropsychological constructs. Method: Path analysis, implemented through structural equation models (SEM), was applied to a sample of N = 193 ED patients, men and women, aged 17 to 50 years old, and diagnosed with bulimia nervosa, night eating syndrome, binge eating disorder, and other specified feeding. Results: BMI was directly associated with ED severity level. The ED symptom level was also a mediational link into the relationship between BMI with emotion regulation strategies, decision-making capacity, stress levels, and impulsiveness. Multigroup SEM revealed invariance of the structural coefficients by sex, but differences according to the ED subtype. Conclusions: This study provides new empirical evidence on predictors of ED severity, focusing on the role of impaired decision-making and BMI. Our results could contribute to new intervention plans with techniques specifically aimed at improving emotional regulation capacity, decreasing impulsivity levels, and improving reasoning skills. Nutrition education plans may also play a key role for preventing the onset and progression of ED, helping patients understand how food affects their physical and emotional health and how to manage anxiety and fears related to food.

Miranda-Yuquilema J.E., Taboada-Pico J., Luna-Velasco D., Cuenca-Condoy M., Briñez W.

In the last decade, the production of guinea pig meat in Andean countries has increased due to the growing number of consumers of this meat. Objective: To evaluate the effect of including different doses (0.50, 1.00, and 1.50 mL) of agro-industrial substrates (molasses distillery waste) fermented with lactic acid bacteria and yeasts on productive performance, hematological profile, relative weight changes in digestive tract organs, and changes in the intestinal microbiota in guinea pigs (Cavia porcellus). Materials: A total of 300 guinea pigs, Kuri breed, aged 20 days and weighing 330 g, were distributed into 10 groups of 30 animals each. Ctrl, Control. La, substrate fermented with Lactobacillus acidophilus (8.1 × 107 CFU/mL). Kf, substrate fermented with Kluyveromyces fragilis (7.4 × 106 CFU/mL). La + Kf, substrate fermented with bacteria and yeasts; the evaluated doses were 0.50, 1.00, and 1.50 mL/animal. The indicators evaluated in the study included weight gain, health, hematological profile, relative weight of digestive tract organs, and changes in the intestinal microbiota. Results: The parameters evaluated were toxicity, productive parameters, occurrence of diarrhea and mortality, and blood profile. The results showed a significant increase in the weight of the animals consuming probiotics, especially at higher doses. Additionally, an improvement in the intestinal microbiota was observed, with an increase in beneficial bacteria such as Lactobacillus and a decrease in pathogenic bacteria. Probiotics also influenced the hematological parameters and the weight of digestive tract organs, suggesting a positive effect on the overall health of the animals. Conclusions: Supplementation with probiotics proved to be a promising strategy for improving productive performance and intestinal health in guinea pigs. Supplementation with L. acidophilus and K. fragilis significantly enhances guinea pig growth and modulates the intestinal microbiota. The combination of strains and appropriate doses maximizes benefits. These results promise applications in animal production, requiring further studies to confirm their efficacy in other species and developmental stages.

Álvarez‐López A.I., Cruz‐Chamorro I., Lardone P.J., Bejarano I., Aspiazu‐Hinostroza K., Ponce‐España E., Santos‐Sánchez G., Álvarez‐Sánchez N., Carrillo‐Vico A.

ABSTRACTTumor necrosis factor (TNF) is a biomarker of inflammation whose levels are elevated in patients with several diseases associated with dysregulation of the immune response. The main limitations of currently used anti‐TNF therapies are the induction of immunodepression, which in many cases leads to serious adverse effects such as infection and cancer, and the inability to cross the blood‐brain barrier in neuroinflammatory conditions. Melatonin, in addition to being a chronobiotic compound, is widely known for its antioxidant and immunomodulatory capacity to control inflammatory processes in different pathological contexts. The aim of the present review is to address human‐based studies that describe the effect of melatonin on TNF production. The review includes all the articles published in PubMed databases until April 15, 2024. After depuration, 45 studies were finally included in the review, 23 related to the in vitro action of melatonin in human cells and 22 in vivo studies in humans. Most of the data reviewed support the idea that melatonin has an immunosuppressive effect on TNF levels, which, together with its low toxicity profile, low cost, and ability to cross the blood‐brain barrier, points to melatonin as a potential anti‐TNF therapy. Therefore, improving our knowledge of the action of melatonin in regulating TNF through appropriate clinical trials would reveal the true potential of this molecule as a possible anti‐TNF therapy.

Icaza D., Vallejo-Ramirez D., Siguencia M., Portocarrero L.

This article presents a review of renewable energy systems in Latin America, highlighting recent advances aimed at transforming electricity markets to make them more environmentally sustainable. The transition of energy systems in these countries is closely linked to policies and legislation that promote the adoption of renewable energy, guided by roadmaps that facilitate planning and decision-making processes. Transportation stands out as a crucial sector in these transition efforts, and support for renewable energy is already driving significant changes in several continents, albeit with different levels of impact. The analysis involved a review of 180 articles published in ScienceDirect since 2000, focused on renewable energy systems in Latin America. Among them, only 40 scientific articles were identified that specifically address electric mobility systems for mass transportation, such as trams and railways, that is environmentally friendly. Currently, their contribution in Latin America is only 1.7%, and it is expected that they will play a fundamental role in the energy transition in 2050, contributing 9.3% within the electrified transportation sector. The results of the research revealed that Brazil, Cuba, Ecuador, Colombia, and Costa Rica are the countries that have carried out the most high-impact research in relation to mobility systems with 100% renewable energy systems. In Latin America, there is a limited number of authors focused on massive electric propulsion systems. The purpose of this research is to provide an overview of the energy situation related to electric propulsion systems for transport in South American countries.

García-Avila F., Asitimbay-Barbecho G., Espinoza-Bustamante M., Valdiviezo-Gonzales L., Sánchez-Cordero E., Cabello-Torres R., Gutiérrez-Ortega H.

This study aimed to compare the water age in a drinking water distribution network (DWDN) using tracers and EPANET. The results indicate that all DWDN have residence times within the "short" time. established by the EPA and does not represent quality problems. These two techniques provided similar estimates of water age with small differences at points close to the treatment plant. This difference may be due to the fact that tracers can be retained in pipes, which overestimates the age of the water; meanwhile, EPANET could underestimate residence times due to the calibration or simplified representation of the network.

Gupta J., Turki Jalil A., Al-hawraa Riyad Muedii Z., Aminov Z., Alsaikhan F., Ramírez-Coronel A., Ramaiah P., Farhood B.

Introduction:: Although radiotherapy is one of the main cancer treatment modalities, exposing healthy organs/tissues to ionizing radiation during treatment and tumor resistance to ionizing radiation are the chief challenges of radiotherapy that can lead to different adverse effects. It was shown that the combined treatment of radiotherapy and natural bioactive compounds (such as silymarin/silibinin) can alleviate the ionizing radiation-induced adverse side effects and induce synergies between these therapeutic modalities. In the present review, the potential radiosensitization effects of silymarin/silibinin during cancer radiation exposure/radiotherapy were studied. Methods:: According to the PRISMA guideline, a systematic search was performed for the identification of relevant studies in different electronic databases of Google Scholar, PubMed, Web of Science, and Scopus up to October 2022. We screened 843 articles in accordance with a predefined set of inclusion and exclusion criteria. Seven studies were finally included in this systematic review. Results:: Compared to the control group, the cell survival/proliferation of cancer cells treated with ionizing radiation was considerably less, and silymarin/silibinin administration synergistically increased ionizing radiation-induced cytotoxicity. Furthermore, there was a decrease in the tumor volume, weight, and growth of ionizing radiation-treated mice as compared to the untreated groups, and these diminutions were predominant in those treated with radiotherapy plus silymarin/ silibinin. Furthermore, the irradiation led to a set of biochemical and histopathological changes in tumoral cells/tissues, and the ionizing radiation-induced alterations were synergized following silymarin/silibinin administration (in most cases). Conclusion:: In most cases, silymarin/silibinin administration could sensitize the cancer cells to ionizing radiation through an increase of free radical formation, induction of DNA damage, increase of apoptosis, inhibition of angiogenesis and metastasis, etc. However, suggesting the use of silymarin/silibinin during radiotherapeutic treatment of cancer patients requires further clinical studies.

Rosales-Asensio E., Icaza D., González-Cobos N., Borge-Diez D.

Microgrids configured using a specific control system to provide correct power quality for local loads that can be either connected or disconnected from the grid, operating grid-connected or islanded mode can be designed to improve the resilience of critical energy systems. In case of grid failure, an energy storage combined with one or several local generators can provide backup power and considering both conventional and renewable energy systems, this research presents an operational resilience analysis for critical facilities, in this case a hospital. The proposed methodology allows studying the possibility to maintain the energy supply and evaluating resilience benefits of a microgrid integrated in critical facilities when power outages occur. Optimization of the dispatch and heating and cooling strategies is presented and analyzed and a case study characterizing an electric polygeneration microgrid feeding critical loads is presented. Results show the benefits and the increased energy resilience resulting from the use of solar PV, electrochemical batteries, combined heat and power, TES water tanks and absorption chillers and proposes a design and optimization scheme that can be applied for similar facilities and extensive to any critical loads. Economic results prove the economic benefits resulting from the use of an optimal resilient microgrid. In particular, it is found that, in the event of an outage, the positive monetary effects last longer than the duration of the outage.

Najafi M., Gupta J., Jalil A.T., abd alzahraa Z.H., Aminov Z., Alsaikhan F., Ramírez-Coronel A.A., Ramaiah P.

Abstract: The immune system is the key player in a wide range of responses in normal tissues and tumors to anticancer therapy. Inflammatory and fibrotic responses in normal tissues are the main limitations of chemotherapy, radiotherapy, and also some newer anticancer drugs such as immune checkpoint inhibitors (ICIs). Immune system responses within solid tumors including anti-tumor and tumor-promoting responses can suppress or help tumor growth. Thus, modulation of immune cells and their secretions such as cytokines, growth factors and epigenetic modulators, pro-apoptosis molecules, and some other molecules can be suggested to alleviate side effects in normal tissues and drug-resistance mechanisms in the tumor. Metformin as an anti-diabetes drug has shown intriguing properties such as anti-inflammation, anti-fibrosis, and anticancer effects. Some investigations have uncovered that metformin can ameliorate radiation/chemotherapy toxicity in normal cells and tissues through the modulation of several targets in cells and tissues. These effects of metformin may ameliorate severe inflammatory responses and fibrosis after exposure to ionizing radiation or following treatment with highly toxic chemotherapy drugs. Metformin can suppress the activity of immunosuppressive cells in the tumor through the phosphorylation of AMP-activated protein kinase (AMPK). In addition, metformin may stimulate antigen presentation and maturation of anticancer immune cells, which lead to the induction of anticancer immunity in the tumor. This review aims to explain the detailed mechanisms of normal tissue sparing and tumor suppression during cancer therapy using adjuvant metformin with an emphasis on immune system responses.

Camacho-Álvarez F.E., Martínez-Contreras S.P., Rodríguez-Chávez J.A., Martínez-Suárez G., González-Aragón Pineda Á.E., Ramos-Montiel R.R., Ramírez-Martínez C.M., Sánchez-García S., Cruz-Hervert L.P., Jiménez-Corona M.E.

The characteristics of the temporomandibular joint (TMJ) are essential in orthodontic and prosthetic treatments. Previous studies have suggested an association between articular eminence inclinations (AEI) and occlusal plane characteristics using radiographs, but no bilateral analysis has been conducted using cone beam computed tomography (CBCT). Objective: This study aimed to investigate the specific characteristics of the occlusal plane inclinations associated with unilateral and bilateral AEI using CBCT. Methods: We conducted a cross-sectional study to evaluate 200 temporomandibular joints (TMJs) from 100 records obtained at the orthodontic department. We evaluated the association between the AEI, and occlusal plane characteristics like the cant of the occlusal angle, occlusal plane angles, inclination of the upper incisor to the Frankfort plane and palatal plane using both bivariate and multivariate analyses both unilaterally and bilaterally. Results: Our findings suggested statistically significant associations (p < 0.050) between AEI (bilateral) and occlusal inclination parameters, including the cant of the occlusal plane (Coef. −0.38; 95%CI −0.70:−0.06; p = 0.017), occlusal plane angle (Coef. −0.39; 95%CI −0.740:−0.05; p = 0.024), and position of the upper incisor relative to the palatal plane (Coef. −0.34; 95%CI −0.63:−0.06; p = 0.016). Conclusion: This study suggests an association between dental inclinations and AEI, which reflects the anatomical characteristics of TMJ and its related dental structures.

Zhiña D.X., Avilés A., González L., Astudillo A., Astudillo J., Matovelle C.

Ecosystem services contribute significantly to human development, with water production being a crucial component. Climate and land use changes can impact water availability within a basin. In this context, researching water-related areas is essential for formulating policies to protect and manage hydrological services. The objective of this study was to estimate water yield in the sub-basins of the Tabacay and Aguilán rivers under climate change scenarios in 2030, 2040, and 2050, combined with scenarios of changes in land cover and land use. The InVEST model was employed to analyze water yield. The results show that crop areas were identified as the lowest water yield in future scenarios, and forested areas, particularly the region where the Cubilán Protected Forest is located, contribute the most to water yield in the subbasin. Besides, water yield has increased in the historic period (2016–2018) due to the conservation and reforestation initiatives carried out by the Municipal Public Service Company for Drinking Water, Sewerage, and Environmental Sanitation of the city of Azogues in 2018, the so-called Reciprocal Agreements for Water. Additionally, an increase in water yield is projected for future scenarios. This study can serve as a basis for decision-makers to identify areas that should prioritize protection and conservation.

Angamarca-Avendaño D., Flores-Vázquez C., Cobos-Torres J.

This research aims at proposing an alternative to improve the efficiency of electric vehicles (EVs) and reduce greenhouse gas (GHG) emissions in the context of electric mobility. A photovoltaic and wind hybrid energy system was installed in a Chok S2 electric vehicle. In addition, a charge equalization system was included to balance and maximize the performance of each of the EV’s five batteries connected in series. The results show a 20% improvement in vehicle efficiency after conducting tests on a 17 km Andean route. The photovoltaic system generated 535 W, while the wind system generated 135 W/s at a speed of 45 km/h. These findings highlight the potential of hybrid renewable energy systems to improve the efficiency and range of electric vehicles.

Moncayo-Molina L., Pino J.A., Spengler I., Moncayo-Rivera C.M., Rojas-Molina J.O.

Toledo-Orozco M., Morales Jadán D., Arévalo Lozado S., Álvarez Bel C.

This research uses data analysis and mining techniques to determine the technological expansion of measurement systems in a public service company. It integrates technical, economic, geographic, and social variables into the analysis using machine learning techniques to discover patterns and relationships in large data sets. The fuzzy logic methodology is applied using the MATLAB programming tool “Fuzzy Logic” to build algorithms that allow for the correct selection of measurement, achieving greater efficiency and precision in the assignment of meter types. The results show that 98% of the metering systems in the significant part are electronic meters, with the “Residential BT” rate being the most extensive data set. Implementing the “fuzzy logic” technique recognizes that more than 60% of the meters are electronic, with the registration of active energy, reactive energy, and demand, allowing for greater control over the marketing variables of the distribution system operator. This research suggests that a future restructuring of electrical metering systems benefits the company and its users. By applying the analysis, a portfolio of viable projects for the replacement of measurement systems is obtained, and they are grouped into two clusters based on the total cost of the technological change.