Open Access

Nature Communications

, volume 15 , issue 1 , publication number 4366

Rediscovery of mononuclear phagocyte system blockade for nanoparticle drug delivery

Ivan V Zelepukin ^{1, 2}

Konstantin G Shevchenko ³

S. M. Deyev ²

Hide authors affiliations Show authors affiliations: 3 affiliations

Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden |

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow, Russia |

Department of Chemistry, Boston University, Boston, USA |

Publication type: Journal Article

Publication date: 2024-05-22

Springer Nature

Nature Communications

scimago Q1

wos Q1

SJR: 4.761

CiteScore: 23.4

Impact factor: 15.7

ISSN: 20411723

DOI: 10.1038/s41467-024-48838-5

Copy DOI

PubMed ID: 38777821

Abstract

Rapid uptake of nanoparticles by mononuclear phagocyte system (MPS) significantly hampers their therapeutic efficacy. Temporal MPS blockade is one of the few ways to overcome this barrier – the approach rediscovered many times under different names but never extensively used in clinic. Using meta-analysis of the published data we prove the efficacy of this technique for enhancing particle circulation in blood and their delivery to tumours, describe a century of its evolution and potential combined mechanism behind it. Finally, we discuss future directions of the research focusing on the features essential for successful clinical translation of the method.

Found

1 citation

Popov Anton

PhD in Biological/biomedical sciences

77 publications, 991 citations, 26 reviews

h-index: 17

Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences

Research interests

Nanomaterials

1 citation

Kuskov Andrey

🥼 🤝

DSc in Chemistry, associate professor

69 publications, 1 405 citations

h-index: 22

Mendeleev University of Chemical Technology of Russia

Research interests

Analysis of complexation between nanoparticles and biomolecules

Biomaterial Science

Biomaterials

Biopolymers - structure

Dispersed systems

Drug delivery

Drug delivery systems

Functionally graded scaffolds

Interaction with biopolymers

Magnetic nanoparticles

Nanoparticles

Polymer Chemistry

Polymer materials

Polymer micro- and nanocontainers with controlled properties

Polymers for drug delivery

Sol-gel chemistry

Targeted delivery

Targeted drug delivery

Toxicology

1 citation

Syuy Alexander

🥼 🤝

DSc in Physics and Mathematics, professor

128 publications, 607 citations, 9 reviews

h-index: 14

Moscow Institute of Physics and Technology

Perm National Research Polytechnic University

Institute On Laser and Information Technologies

Research interests

Nanoparticles

1 citation

Shemyakov Alexander

50 publications, 179 citations

h-index: 7

Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences

P.N. Lebedev Physical Institute of the Russian Academy of Sciences

1 citation

Chukavin Nikita

24 publications, 73 citations

h-index: 6

Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences

Research interests

Cell biology

Theranostics

1 citation

Shakhov Pavel

🤝

15 publications, 101 citations

h-index: 6

National Research Nuclear University MEPhI

Research interests

Laser ablation

1 citation

Popov Anton

🥼 🤝

PhD in Physics and Mathematics

75 publications, 1 237 citations, 8 reviews

h-index: 19

National Research Nuclear University MEPhI

1 citation

Tihonowski Gleb

🤝

41 publications, 454 citations

h-index: 11

National Research Nuclear University MEPhI

Research interests

Nanoparticles

1 citation

Savinov Maxim

🤝

17 publications, 35 citations

h-index: 3

National Research Nuclear University MEPhI

Research interests

Biomedicine

Colloidal nanoparticles

Laser ablation

Nanomaterials

Nanomaterials for biomedicine

Pulsed laser ablation in liquid

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GOST Copy

Zelepukin I. V. et al. Rediscovery of mononuclear phagocyte system blockade for nanoparticle drug delivery // Nature Communications. 2024. Vol. 15. No. 1. 4366

GOST all authors (up to 50) Copy

Zelepukin I. V., Shevchenko K. G., Deyev S. M. Rediscovery of mononuclear phagocyte system blockade for nanoparticle drug delivery // Nature Communications. 2024. Vol. 15. No. 1. 4366

RIS |

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RIS Copy

TY - JOUR

DO - 10.1038/s41467-024-48838-5

UR - https://www.nature.com/articles/s41467-024-48838-5

TI - Rediscovery of mononuclear phagocyte system blockade for nanoparticle drug delivery

T2 - Nature Communications

AU - Zelepukin, Ivan V

AU - Shevchenko, Konstantin G

AU - Deyev, S. M.

PY - 2024

DA - 2024/05/22

PB - Springer Nature

IS - 1

VL - 15

PMID - 38777821

SN - 2041-1723

ER -

BibTex

Cite this

BibTex (up to 50 authors) Copy

@article{2024_Zelepukin,

author = {Ivan V Zelepukin and Konstantin G Shevchenko and S. M. Deyev},

title = {Rediscovery of mononuclear phagocyte system blockade for nanoparticle drug delivery},

journal = {Nature Communications},

year = {2024},

volume = {15},

publisher = {Springer Nature},

month = {may},

url = {https://www.nature.com/articles/s41467-024-48838-5},

number = {1},

pages = {4366},

doi = {10.1038/s41467-024-48838-5}

}

Publisher

Springer Nature

Journal

Nature Communications

scimago Q1

wos Q1

SJR

4.761

CiteScore

23.4

Impact factor

15.7

ISSN

20411723 (Print, Electronic)

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