A framework for advancing our understanding of cancer-associated fibroblasts
Erik Sahai
1
,
Igor A. Astsaturov
2
,
Edna Cukierman
3
,
David G. DeNardo
4
,
Mikala Egeblad
5
,
Ronald M. Evans
6, 7
,
Douglas Fearon
5, 8
,
F. Greten
9, 10
,
Sunil R. Hingorani
11
,
Tony Hunter
12
,
Richard O. Hynes
13
,
Rakesh Kumar Jain
14
,
Tobias Janowitz
5, 15
,
Claus Jorgensen
16
,
Alec C. Kimmelman
17
,
Mikhail G. Kolonin
18
,
Robert G. Maki
5, 19, 20
,
R Scott Powers
21
,
Ellen Puré
22
,
Daniel C Ramirez
23
,
Ruth Scherz Shouval
24
,
Mara H Sherman
25
,
Sheila Stewart
26
,
Thea D. Tlsty
27, 28
,
David A. Tuveson
5
,
F. M. Watt
29
,
Valerie Weaver
30
,
Ashani T. Weeraratna
31
,
Zena Werb
32
7
9
Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus, Frankfurt, Germany
|
10
14
15
Northwell Health Cancer Institute, New Hyde Park, USA
|
16
19
Northwell Health Cancer Institute, New York, USA
|
23
Zucker School of Medicine at Hofstra/Northwell Health System, New York, USA
|
29
Publication type: Journal Article
Publication date: 2020-01-24
scimago Q1
wos Q1
SJR: 24.378
CiteScore: 103.8
Impact factor: 66.8
ISSN: 1474175X, 14741768
PubMed ID:
31980749
General Environmental Science
General Earth and Planetary Sciences
Abstract
Cancer-associated fibroblasts (CAFs) are a key component of the tumour microenvironment with diverse functions, including matrix deposition and remodelling, extensive reciprocal signalling interactions with cancer cells and crosstalk with infiltrating leukocytes. As such, they are a potential target for optimizing therapeutic strategies against cancer. However, many challenges are present in ongoing attempts to modulate CAFs for therapeutic benefit. These include limitations in our understanding of the origin of CAFs and heterogeneity in CAF function, with it being desirable to retain some antitumorigenic functions. On the basis of a meeting of experts in the field of CAF biology, we summarize in this Consensus Statement our current knowledge and present a framework for advancing our understanding of this critical cell type within the tumour microenvironment. This Consensus Statement highlights the importance of cancer-associated fibroblasts in cancer biology and progression, and issues a call to action for all cancer researchers to standardize assays and report metadata in studies of cancer-associated fibroblasts to advance our understanding of this important cell type in the tumour microenvironment.
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GOST
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Sahai E. et al. A framework for advancing our understanding of cancer-associated fibroblasts // Nature Reviews Cancer. 2020. Vol. 20. No. 3. pp. 174-186.
GOST all authors (up to 50)
Copy
Sahai E., Astsaturov I. A., Cukierman E., DeNardo D. G., Egeblad M., Evans R. M., Fearon D., Greten F., Hingorani S. R., Hunter T., Hynes R. O., Jain R. K., Janowitz T., Jorgensen C., Kimmelman A. C., Kolonin M. G., Maki R. G., Powers R. S., Puré E., Ramirez D. C., Scherz Shouval R., Sherman M. H., Stewart S., Tlsty T. D., Tuveson D. A., Watt F. M., Weaver V., Weeraratna A. T., Werb Z. A framework for advancing our understanding of cancer-associated fibroblasts // Nature Reviews Cancer. 2020. Vol. 20. No. 3. pp. 174-186.
Cite this
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TY - JOUR
DO - 10.1038/s41568-019-0238-1
UR - https://www.nature.com/articles/s41568-019-0238-1
TI - A framework for advancing our understanding of cancer-associated fibroblasts
T2 - Nature Reviews Cancer
AU - Sahai, Erik
AU - Astsaturov, Igor A.
AU - Cukierman, Edna
AU - DeNardo, David G.
AU - Egeblad, Mikala
AU - Evans, Ronald M.
AU - Fearon, Douglas
AU - Greten, F.
AU - Hingorani, Sunil R.
AU - Hunter, Tony
AU - Hynes, Richard O.
AU - Jain, Rakesh Kumar
AU - Janowitz, Tobias
AU - Jorgensen, Claus
AU - Kimmelman, Alec C.
AU - Kolonin, Mikhail G.
AU - Maki, Robert G.
AU - Powers, R Scott
AU - Puré, Ellen
AU - Ramirez, Daniel C
AU - Scherz Shouval, Ruth
AU - Sherman, Mara H
AU - Stewart, Sheila
AU - Tlsty, Thea D.
AU - Tuveson, David A.
AU - Watt, F. M.
AU - Weaver, Valerie
AU - Weeraratna, Ashani T.
AU - Werb, Zena
PY - 2020
DA - 2020/01/24
PB - Springer Nature
SP - 174-186
IS - 3
VL - 20
PMID - 31980749
SN - 1474-175X
SN - 1474-1768
ER -
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@article{2020_Sahai,
author = {Erik Sahai and Igor A. Astsaturov and Edna Cukierman and David G. DeNardo and Mikala Egeblad and Ronald M. Evans and Douglas Fearon and F. Greten and Sunil R. Hingorani and Tony Hunter and Richard O. Hynes and Rakesh Kumar Jain and Tobias Janowitz and Claus Jorgensen and Alec C. Kimmelman and Mikhail G. Kolonin and Robert G. Maki and R Scott Powers and Ellen Puré and Daniel C Ramirez and Ruth Scherz Shouval and Mara H Sherman and Sheila Stewart and Thea D. Tlsty and David A. Tuveson and F. M. Watt and Valerie Weaver and Ashani T. Weeraratna and Zena Werb},
title = {A framework for advancing our understanding of cancer-associated fibroblasts},
journal = {Nature Reviews Cancer},
year = {2020},
volume = {20},
publisher = {Springer Nature},
month = {jan},
url = {https://www.nature.com/articles/s41568-019-0238-1},
number = {3},
pages = {174--186},
doi = {10.1038/s41568-019-0238-1}
}
Cite this
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Sahai, Erik, et al. “A framework for advancing our understanding of cancer-associated fibroblasts.” Nature Reviews Cancer, vol. 20, no. 3, Jan. 2020, pp. 174-186. https://www.nature.com/articles/s41568-019-0238-1.
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