Nature, volume 584, issue 7819, pages 120-124

A human neutralizing antibody targets the receptor-binding site of SARS-CoV-2

Rui Shi ^{1, 2}

Chao Shan ³

Xiaomin Duan ^{1, 2}

Zhi-Hai Chen ⁴

Peipei Liu ⁵

Jin-Wen Song ⁶

Tao Song ^{2, 7, 8}

Xiaoshan Bi ^{2, 9}

Chao Han ^{1, 2}

Lianao Wu ^{9, 10}

Ge Gao ³

Xue Hu ³

Yanan Zhang ³

Tong Zhou ^{2, 10}

Weijin Huang ¹¹

William Jun Liu ⁵

Guizhen Wu ⁵

Bo Zhang ³

Lan Wang ¹¹

Jianxun Qi ^{10, 12}

Feng Hui ¹³

Fusheng Wang ⁶

Qihui Wang ^{2, 10, 12}

George F. Gao ¹⁰

Zhiming Yuan ³

Jinghua Yan ^{2, 10, 12}

Hide authors affiliations Show authors affiliations: 13 affiliations

University of Chinese Academy of Sciences, BeiJing, China |

CAS Key Laboratory of Microbial Physiological and Metabolic engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China |

Center for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China |

⁴

Center of Infectious Disease, Beijing Ditan Hospital, Capital Medical University, Beijing, China |

⁵

NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center For Disease Control and Prevention, Beijing, China |

⁶

Treatment and Research Center for Infectious Diseases, The Fifth Medical Center of PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing, China |

⁷

Shanxi Academy of Advanced Research and Innovation, Taiyuan, China |

⁸

College of Animal Science and Technology, Hebei Normal University of Science and Technology, Qinhuangdao, China |

⁹

Institute of Physical Science and Information, Anhui University, Hefei, China |

¹⁰

CAS key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China |

¹¹

Key Laboratory of the Ministry of Health for Research on Quality and Standardization of Biotech Products, National Institutes for Food and Drug Control, Beijing, China |

¹²

Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China |

¹³

Shanghai Junshi Biosciences Co. Ltd, Shanghai, China |

Publication type: Journal Article

Publication date: 2020-05-26

Springer Nature

Journal: Nature

Quartile SCImago

Quartile WOS

Impact factor: 64.8

ISSN: 00280836, 14764687

DOI: 10.1038/s41586-020-2381-y

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Multidisciplinary

Abstract

An outbreak of coronavirus disease 2019 (COVID-19)1–3, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)4, has spread globally. Countermeasures are needed to treat and prevent further dissemination of the virus. Here we report the isolation of two specific human monoclonal antibodies (termed CA1 and CB6) from a patient convalescing from COVID-19. CA1 and CB6 demonstrated potent SARS-CoV-2-specific neutralization activity in vitro. In addition, CB6 inhibited infection with SARS-CoV-2 in rhesus monkeys in both prophylactic and treatment settings. We also performed structural studies, which revealed that CB6 recognizes an epitope that overlaps with angiotensin-converting enzyme 2 (ACE2)-binding sites in the SARS-CoV-2 receptor-binding domain, and thereby interferes with virus–receptor interactions by both steric hindrance and direct competition for interface residues. Our results suggest that CB6 deserves further study as a candidate for translation to the clinic. Two monoclonal antibodies isolated from a patient with COVID-19 are shown to interfere with SARS-CoV-2–receptor binding, and one displays potent action against this virus in vitro and in a rhesus macaque model.

By date By citations

Top-30

Citations by journals

	5 10 15 20 25 30 35 40
Nature Communications	Nature Communications, 37, 3.08% Nature Communications 37 publications, 3.08%
Frontiers in Immunology	Frontiers in Immunology, 32, 2.66% Frontiers in Immunology 32 publications, 2.66%
Cell Reports	Cell Reports, 27, 2.24% Cell Reports 27 publications, 2.24%
Cell	Cell, 26, 2.16% Cell 26 publications, 2.16%
Vaccines	Vaccines, 20, 1.66% Vaccines 20 publications, 1.66%
Nature	Nature, 18, 1.5% Nature 18 publications, 1.5%
Viruses	Viruses, 17, 1.41% Viruses 17 publications, 1.41%
Science	Science, 16, 1.33% Science 16 publications, 1.33%
PLoS Pathogens	PLoS Pathogens, 16, 1.33% PLoS Pathogens 16 publications, 1.33%
Signal Transduction and Targeted Therapy	Signal Transduction and Targeted Therapy, 15, 1.25% Signal Transduction and Targeted Therapy 15 publications, 1.25%
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 14, 1.16% International Journal of Molecular Sciences 14 publications, 1.16%
Emerging Microbes and Infections	Emerging Microbes and Infections, 14, 1.16% Emerging Microbes and Infections 14 publications, 1.16%
Cell Host and Microbe	Cell Host and Microbe, 12, 1% Cell Host and Microbe 12 publications, 1%
Science Translational Medicine	Science Translational Medicine, 11, 0.91% Science Translational Medicine 11 publications, 0.91%
Scientific Reports	Scientific Reports, 11, 0.91% Scientific Reports 11 publications, 0.91%
iScience	iScience, 10, 0.83% iScience 10 publications, 0.83%
Cell Discovery	Cell Discovery, 10, 0.83% Cell Discovery 10 publications, 0.83%
Cell Reports Medicine	Cell Reports Medicine, 10, 0.83% Cell Reports Medicine 10 publications, 0.83%
Immunity	Immunity, 10, 0.83% Immunity 10 publications, 0.83%
mAbs	mAbs, 9, 0.75% mAbs 9 publications, 0.75%
Journal of Virology	Journal of Virology, 8, 0.67% Journal of Virology 8 publications, 0.67%
Proceedings of the National Academy of Sciences of the United States of America	Proceedings of the National Academy of Sciences of the United States of America, 8, 0.67% Proceedings of the National Academy of Sciences of the United States of America 8 publications, 0.67%
Frontiers in Microbiology	Frontiers in Microbiology, 7, 0.58% Frontiers in Microbiology 7 publications, 0.58%
Computational and Structural Biotechnology Journal	Computational and Structural Biotechnology Journal, 7, 0.58% Computational and Structural Biotechnology Journal 7 publications, 0.58%
Journal of Molecular Biology	Journal of Molecular Biology, 7, 0.58% Journal of Molecular Biology 7 publications, 0.58%
Microbiology spectrum	Microbiology spectrum, 7, 0.58% Microbiology spectrum 7 publications, 0.58%
Antibody Therapeutics	Antibody Therapeutics, 7, 0.58% Antibody Therapeutics 7 publications, 0.58%
Communications Biology	Communications Biology, 6, 0.5% Communications Biology 6 publications, 0.5%
Journal of Medical Virology	Journal of Medical Virology, 6, 0.5% Journal of Medical Virology 6 publications, 0.5%
	5 10 15 20 25 30 35 40

Citations by publishers

	50 100 150 200 250 300
Cold Spring Harbor Laboratory	Cold Spring Harbor Laboratory, 273, 22.69% Cold Spring Harbor Laboratory 273 publications, 22.69%
Elsevier	Elsevier, 236, 19.62% Elsevier 236 publications, 19.62%
Springer Nature	Springer Nature, 211, 17.54% Springer Nature 211 publications, 17.54%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 82, 6.82% Multidisciplinary Digital Publishing Institute (MDPI) 82 publications, 6.82%
Frontiers Media S.A.	Frontiers Media S.A., 62, 5.15% Frontiers Media S.A. 62 publications, 5.15%
Wiley	Wiley, 45, 3.74% Wiley 45 publications, 3.74%
American Chemical Society (ACS)	American Chemical Society (ACS), 43, 3.57% American Chemical Society (ACS) 43 publications, 3.57%
American Association for the Advancement of Science (AAAS)	American Association for the Advancement of Science (AAAS), 32, 2.66% American Association for the Advancement of Science (AAAS) 32 publications, 2.66%
Oxford University Press	Oxford University Press, 31, 2.58% Oxford University Press 31 publications, 2.58%
American Society for Microbiology	American Society for Microbiology, 25, 2.08% American Society for Microbiology 25 publications, 2.08%
Public Library of Science (PLoS)	Public Library of Science (PLoS), 24, 2% Public Library of Science (PLoS) 24 publications, 2%
Taylor & Francis	Taylor & Francis, 24, 2% Taylor & Francis 24 publications, 2%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 8, 0.67% Royal Society of Chemistry (RSC) 8 publications, 0.67%
Proceedings of the National Academy of Sciences (PNAS)	Proceedings of the National Academy of Sciences (PNAS), 8, 0.67% Proceedings of the National Academy of Sciences (PNAS) 8 publications, 0.67%
Rockefeller University Press	Rockefeller University Press, 7, 0.58% Rockefeller University Press 7 publications, 0.58%
American Society for Clinical Investigation	American Society for Clinical Investigation, 5, 0.42% American Society for Clinical Investigation 5 publications, 0.42%
American Society for Biochemistry and Molecular Biology	American Society for Biochemistry and Molecular Biology, 5, 0.42% American Society for Biochemistry and Molecular Biology 5 publications, 0.42%
Social Science Electronic Publishing	Social Science Electronic Publishing, 5, 0.42% Social Science Electronic Publishing 5 publications, 0.42%
Spandidos Publications	Spandidos Publications, 4, 0.33% Spandidos Publications 4 publications, 0.33%
KeAi Communications Co.	KeAi Communications Co., 4, 0.33% KeAi Communications Co. 4 publications, 0.33%
EMBO press	EMBO press, 4, 0.33% EMBO press 4 publications, 0.33%
Dove Medical Press	Dove Medical Press, 3, 0.25% Dove Medical Press 3 publications, 0.25%
Wolters Kluwer Health	Wolters Kluwer Health, 3, 0.25% Wolters Kluwer Health 3 publications, 0.25%
NEJM Group	NEJM Group, 2, 0.17% NEJM Group 2 publications, 0.17%
The American Association of Immunologists	The American Association of Immunologists, 2, 0.17% The American Association of Immunologists 2 publications, 0.17%
Bentham Science	Bentham Science, 2, 0.17% Bentham Science 2 publications, 0.17%
Mary Ann Liebert	Mary Ann Liebert, 2, 0.17% Mary Ann Liebert 2 publications, 0.17%
SAGE	SAGE, 2, 0.17% SAGE 2 publications, 0.17%
Hindawi Limited	Hindawi Limited, 2, 0.17% Hindawi Limited 2 publications, 0.17%
	50 100 150 200 250 300

We do not take into account publications without a DOI.
Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
Statistics recalculated weekly.

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GOST |

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Shi R. et al. A human neutralizing antibody targets the receptor-binding site of SARS-CoV-2 // Nature. 2020. Vol. 584. No. 7819. pp. 120-124.

GOST all authors (up to 50) Copy

Shi R., Shan C., Duan X., Chen Z., Liu P., Song J., Song T., Bi X., Han C., Wu L., Gao G., Hu X., Zhang Y., Zhou T., Huang W., Liu W. J., Wu G., Zhang B., Wang L., Qi J., Hui F., Wang F., Wang Q., Gao G. F., Yuan Z., Yan J. A human neutralizing antibody targets the receptor-binding site of SARS-CoV-2 // Nature. 2020. Vol. 584. No. 7819. pp. 120-124.

RIS |

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TY - JOUR

DO - 10.1038/s41586-020-2381-y

UR - https://doi.org/10.1038/s41586-020-2381-y

TI - A human neutralizing antibody targets the receptor-binding site of SARS-CoV-2

T2 - Nature

AU - Shi, Rui

AU - Shan, Chao

AU - Duan, Xiaomin

AU - Chen, Zhi-Hai

AU - Liu, Peipei

AU - Song, Jin-Wen

AU - Song, Tao

AU - Bi, Xiaoshan

AU - Han, Chao

AU - Wu, Lianao

AU - Gao, Ge

AU - Hu, Xue

AU - Zhang, Yanan

AU - Zhou, Tong

AU - Huang, Weijin

AU - Liu, William Jun

AU - Wu, Guizhen

AU - Zhang, Bo

AU - Wang, Lan

AU - Qi, Jianxun

AU - Hui, Feng

AU - Wang, Fusheng

AU - Wang, Qihui

AU - Gao, George F.

AU - Yuan, Zhiming

AU - Yan, Jinghua

PY - 2020

DA - 2020/05/26 00:00:00

PB - Springer Nature

SP - 120-124

IS - 7819

VL - 584

SN - 0028-0836

SN - 1476-4687

ER -

BibTex |

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BibTex Copy

@article{2020_Shi,

author = {Rui Shi and Chao Shan and Xiaomin Duan and Zhi-Hai Chen and Peipei Liu and Jin-Wen Song and Tao Song and Xiaoshan Bi and Chao Han and Lianao Wu and Ge Gao and Xue Hu and Yanan Zhang and Tong Zhou and Weijin Huang and William Jun Liu and Guizhen Wu and Bo Zhang and Lan Wang and Jianxun Qi and Feng Hui and Fusheng Wang and Qihui Wang and George F. Gao and Zhiming Yuan and Jinghua Yan},

title = {A human neutralizing antibody targets the receptor-binding site of SARS-CoV-2},

journal = {Nature},

year = {2020},

volume = {584},

publisher = {Springer Nature},

month = {may},

url = {https://doi.org/10.1038/s41586-020-2381-y},

number = {7819},

pages = {120--124},

doi = {10.1038/s41586-020-2381-y}

}

MLA

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MLA Copy

Shi, Rui, et al. “A human neutralizing antibody targets the receptor-binding site of SARS-CoV-2.” Nature, vol. 584, no. 7819, May. 2020, pp. 120-124. https://doi.org/10.1038/s41586-020-2381-y.

Found error?

Publisher

Springer Nature

Journal

Nature

Quartile SCImago

Quartile WOS

Impact factor

64.8

ISSN

00280836 (Print)
14764687 (Electronic)