Nature Genetics

, том 53 , издание 6 , страницы 840-860

The trans-ancestral genomic architecture of glycemic traits

Ji Chen ^{1, 2}

Cassandra N Spracklen ^{3, 4}

Gaëlle Marenne ^{2, 5}

Arushi Varshney ⁶

Laura J. Corbin ^{7, 8}

Jian'an Luan ⁹

Sara M Willems ⁹

Ying Wu ³

Xiaoshuai Zhang ^{9, 10}

Momoko Horikoshi ^{11, 12, 13}

Thibaud S. Boutin ¹⁴

Reedik Mägi ¹⁵

Johannes Waage ¹⁶

Ruifang Li-Gao ¹⁷

Kei Hang Katie Chan ^{18, 19, 20}

JIE YAO ²¹

Mila D Anasanti ²²

Audrey Y. Chu ²³

Annique Claringbould ²⁴

Jani Heikkinen ²²

Jaeyoung Hong ²⁵

Jouke-Jan Hottenga ^{26, 27}

Shaofeng Huo ²⁸

Marika A. Kaakinen ^{22, 29}

Tin Louie ³⁰

Winfried März ^{31, 32, 33}

Hortensia Moreno-Macías ³⁴

Anne Ndungu ¹²

Sarah C Nelson ³⁰

Ilja M. Nolte ³⁵

Kari E. North ³⁶

Chelsea K Raulerson ³

Debashree Ray ³⁷

Rebecca Rohde ³⁶

Denis Rybin ²⁵

Claudia Schurmann ^{38, 39}

Xueling Sim ^{40, 41, 42}

Lorraine Southam ^{2, 43}

Isobel D. Stewart ⁹

Carol A. Wang ⁴⁴

Yujie Wang ³⁶

Peitao Wu ²⁵

Weihua Zhang ^{45, 46}

Tarunveer S Ahluwalia ^{16, 47, 48}

Emil V R Appel ⁴⁹

Lawrence F. Bielak ⁵⁰

Jennifer A. Brody ⁵¹

Noël P. Burtt ⁵²

Claudia P. Cabrera ^{53, 54}

Brian E. Cade ^{55, 56}

Jin Fang Chai ⁴⁰

Xiaoran Chai ^{57, 58}

Li-Ching Chang ⁵⁹

Chien-Hsiun Chen ⁵⁹

Brian H Chen ⁶⁰

Kumaraswamy Naidu Chitrala ⁶¹

Yen-Feng Chiu ⁶²

Graciela E. Delgado ³³

Ayse Demirkan ^{29, 63}

Qing Duan ^{3, 64}

Jorgen Engmann ⁶⁵

Segun A Fatumo ^{66, 67, 68}

Javier Gayán ⁶⁹

Franco Giulianini ²³

Jung Ho Gong ¹⁸

Stefan Gustafsson ⁷⁰

Yang Hai ⁷¹

Fernando P. Hartwig ^{7, 72}

Jing He ⁷³

Yoriko Heianza ⁷⁴

Tao Huang ⁷⁵

Alicia Huerta Chagoya ^{76, 77}

MI YEONG HWANG ⁷⁸

RICHARD A. JENSEN ⁵¹

Takahisa Kawaguchi ⁷⁹

Katherine A Kentistou ^{80, 81}

Young Jin Kim ⁷⁸

Marcus E. Kleber ³³

Ishminder K Kooner ⁴⁶

Shuiqing Lai ¹⁸

Leslie A Lange ⁸²

Carl D Langefeld ⁸³

Marie Lauzon ²¹

Man Li ⁸⁴

Symen Ligthart ⁶³

Jun Liu ^{63, 85}

Marie Loh ^{45, 86}

Jirong Long ⁸⁷

Valeriya Lyssenko ^{88, 89}

Massimo Mangino ^{90, 91}

Carola Marzi ^{92, 93}

May E. Montasser ⁹⁴

Abhishek Nag ¹²

Masahiro Nakatochi ⁹⁵

Damia Noce ⁹⁶

Raymond Noordam ⁹⁷

Giorgio Pistis ⁹⁸

Michael Preuss ^{38, 99}

Laura Raffield ³

Laura J. Rasmussen-Torvik ¹⁰⁰

Stephen S Rich ^{101, 102}

Neil R. Robertson ^{11, 12}

Rico Rueedi ^{103, 104}

Kathleen Ryan ⁹⁴

Serena Sanna ^{24, 98}

Richa Saxena ^{105, 106, 107}

Katharina E. Schraut ^{80, 81}

Bengt Sennblad ¹⁰⁸

Kazuya Setoh ⁷⁹

Albert V. Smith ^{109, 110}

Thomas Sparsø ⁴⁹

Rona J Strawbridge ^{111, 112}

Fumihiko Takeuchi ¹¹³

Jingyi Tan ²¹

Stella Trompet ^{97, 114}

Niek Verweij ^{115, 116}

Mandy Vogel ¹¹⁷

Heming Wang ^{55, 56}

Chaolong Wang ^{118, 119}

Nan Wang ^{120, 121}

Helen R Warren ^{53, 54}

Wanqing Wen ⁸⁷

Tom Wilsgaard ¹²²

Andrew Wong ¹²³

Andrew R. Wood ¹

Tian Xie ³⁵

Mohammad Hadi Zafarmand ^{124, 125}

Jing Hua Zhao ¹²⁶

Wei Zhao ⁵⁰

Najaf Amin ^{63, 85}

Zorayr Arzumanyan ²¹

Arne Astrup ¹²⁷

Stephan J.L. Bakker ¹²⁸

Damiano Baldassarre ^{129, 130}

Marian Beekman ¹³¹

Richard N. Bergman ¹³²

Alain Bertoni ¹³³

Matthias Blüher ¹³⁴

Lori L. Bonnycastle ¹³⁵

Stefan R. Bornstein ¹³⁶

Donald W Bowden ¹³⁷

Qiuyin Cai ⁷³

Archie Campbell ^{138, 139}

Harry Campbell ⁸⁰

Yi-Cheng Chang ^{59, 140, 141}

Abbas Dehghan ⁶³

Shufa Du ¹⁴²

Gudny Eiriksdottir ¹¹⁰

Aliki-Eleni Farmaki ^{143, 144}

Mattias Frånberg ¹¹²

Christian Fuchsberger ⁹⁶

Yutang Gao ¹⁴⁵

Anette P Gjesing ⁴⁹

Anuj Goel ^{12, 146}

Sohee Han ⁷⁸

Catharina A Hartman ¹⁴⁷

Christian Herder ^{148, 149, 150}

Andrew A. Hicks ⁹⁶

Chang-Hsun Hsieh ^{151, 152}

Willa A. Hsueh ¹⁵³

Sahoko Ichihara ¹⁵⁴

Michiya Igase ¹⁵⁵

M. Arfan Ikram ⁶³

W. Craig Johnson ³⁰

Marit E. Jørgensen ^{47, 156}

Peter K Joshi ⁸⁰

Rita R. Kalyani ¹⁵⁷

Fouad R Kandeel ¹⁵⁸

Tomohiro Katsuya ^{159, 160}

Chiea Chuen Khor ¹¹⁹

Wieland Kiess ¹¹⁷

Ivana Kolcic ¹⁶¹

Teemu Kuulasmaa ¹⁶²

Johanna Kuusisto ¹⁶³

Kristi Läll ¹⁵

Kelvin Lam ²¹

Deborah A. Lawlor ^{7, 8}

Nanette R. Lee ^{164, 165}

Rozenn N. Lemaitre ⁵¹

Honglan Li ¹⁶⁶

Shih-Yi Lin ^{167, 168}

Jaana Lindström ¹⁶⁹

Allan Linneberg ^{170, 171}

Jianjun Liu ^{119, 172}

Carlos Lorenzo ¹⁷³

Tatsuaki Matsubara ¹⁷⁴

Fumihiko Matsuda ⁷⁹

Geltrude Mingrone ¹⁷⁵

Simon Mooijaart ⁹⁷

Sanghoon Moon ⁷⁸

Toru Nabika ¹⁷⁶

Girish N Nadkarni ³⁸

Jerry L. Nadler ¹⁷⁷

Mari Nelis ¹⁵

Matt J Neville ^{11, 178}

Jill M. Norris ¹⁷⁹

Yasumasa Ohyagi ¹⁸⁰

Annette Peters ^{93, 181, 182}

Patricia A. Peyser ⁵⁰

Ozren Polašek ^{161, 183}

Qibin Qi ¹⁸⁴

Dennis Raven ¹⁴⁷

Dermot F. Reilly ¹⁸⁵

Alex Reiner ¹⁸⁶

Fernando Rivideneira ¹⁸⁷

Kathryn Roll ²¹

Igor Rudan ¹⁸⁸

Charumathi Sabanayagam ^{57, 189}

Kevin Sandow ²¹

Naveed Sattar ¹⁹⁰

Annette Schürmann ^{93, 191}

Jinxiu Shi ¹⁹²

Heather M. Stringham ^{41, 42}

Kent D. Taylor ²¹

Tanya M. Teslovich ¹⁹³

Betina Thuesen ¹⁷⁰

Paul R H J Timmers ^{80, 194}

Elena Tremoli ¹³⁰

MICHAEL Y. TSAI ¹⁹⁵

Andre Uitterlinden ¹⁸⁷

Vliet-Ostaptchouk Jana V van ³⁵

Jagadish Vangipurapu ¹⁹⁶

Henrik VESTERGAARD ^{49, 197}

Tao Wang ¹⁸⁴

Ko Willems van Dijk ^{198, 199, 200}

Tatijana Zemunik ²⁰¹

Gonçalo R. Abecasis ⁴²

Linda S Adair ^{142, 202}

Carlos Alberto Aguilar-Salinas ^{203, 204, 205}

Marta E. Alarcón-Riquelme ^{206, 207}

Ping An ²⁰⁸

Larissa Avilés Santa ²⁰⁹

Diane M Becker ²¹⁰

Lawrence J. Beilin ²¹¹

Sven Bergmann ^{103, 104, 212}

Hans Bisgaard ¹⁶

Corri Black ²¹³

Michael Boehnke ^{41, 42}

Eric Boerwinkle ^{214, 215}

Bernhard O. Böhm ^{216, 217}

Klaus Bønnelykke ¹⁶

D.I. Boomsma ^{26, 27}

Erwin P. Bottinger ^{38, 218, 219}

Thomas A. Buchanan ^{121, 220, 221}

Mickaël Canouil ^{222, 223}

Mark J. Caulfield ^{53, 54}

John C Chambers ^{45, 46, 86, 224, 225}

Daniel I. Chasman ^{23, 226}

Yii-Der Ida Chen ²¹

Ching-Yu Cheng ^{57, 189}

Francis S. Collins ¹³⁵

Adolfo Correa ²²⁷

Francesco Cucca ⁹⁸

George Dedoussis ²²⁸

Sölve Elmståhl ²²⁹

Michele K. Evans ²³⁰

Ele Ferrannini ²³¹

Luigi Ferrucci ²³²

Jose C Florez ^{107, 233, 234}

Paul W Franks ^{89, 235}

Timothy M. Frayling ¹

Philippe Froguel ^{222, 223, 236}

Bruna Gigante ²³⁷

Mark O. Goodarzi ²³⁸

Penny Gordon-Larsen ^{142, 202}

Harald Grallert ^{92, 93}

Niels Grarup ⁴⁹

Sameline Grimsgaard ¹²²

Leif Groop ^{239, 240}

Vilmundur Gudnason ^{110, 241}

Xiuqing Guo ²¹

Anders Hamsten ¹¹²

Torben Hansen ⁴⁹

Caroline Hayward ¹⁹⁴

Susan R. Heckbert ²⁴²

Bernardo L. Horta ⁷²

Wei Huang ¹⁹²

Erik Ingelsson ²⁴³

Pankow S James ²⁴⁴

Marjo-Ritta Järvelin ^{245, 246, 247, 248}

Jost B. Jonas ^{249, 250, 251}

J. Wouter Jukema ^{114, 252}

Pontiano Kaleebu ²⁵³

Robert Kaplan ^{184, 186}

Sharon L. R. Kardia ⁵⁰

Norihiro Kato ¹¹³

Sirkka M Keinänen Kiukaanniemi ^{254, 255}

Bong-Jo Kim ⁷⁸

Mika Kivimaki ²⁵⁶

Heikki A. Koistinen ^{257, 258, 259}

Jaspal S. Kooner ^{46, 224, 225, 260}

Antje Körner ¹¹⁷

Peter Kovacs ^{134, 261}

Diana Kuh ¹²³

Meena Kumari ²⁶²

Zoltán Kutalik ^{104, 263}

Markku Laakso ¹⁶³

Timo A. Lakka ^{264, 265, 266}

Lenore J. Launer ⁶¹

Karin Leander ²⁶⁷

Huaixing Li ²⁸

Xu Lin ²⁸

Lars Lind ²⁶⁸

Cecilia Lindgren ^{12, 269, 270}

Simin Liu ¹⁸

Ruth J.F. Loos ^{38, 99}

Patrik K.E. Magnusson ²⁷¹

Anubha Mahajan ^{12, 272}

Andres Metspalu ¹⁵

Dennis O. Mook-Kanamori ^{17, 273}

Trevor A. Mori ²¹¹

Patricia B. Munroe ^{53, 54}

Inger Njølstad ¹²²

Jeffrey R O'Connell ⁹⁴

Albertine J Oldehinkel ¹⁴⁷

Ken K. Ong ⁹

SANDOSH PADMANABHAN ²⁷⁴

Colin N.A. Palmer ²⁷⁵

Nicholette D. Palmer ¹³⁷

Oluf Pedersen ⁴⁹

Craig E. Pennell ⁴⁴

David J. Porteous ^{138, 276}

Peter P. Pramstaller ⁹⁶

Michael A Province ²⁰⁸

Bruce M. Psaty ^{51, 242, 277}

Qi Lu ²⁷⁸

LESLIE J. RAFFEL ²⁷⁹

Rainer Rauramaa ²⁶⁶

Susan Redline ^{55, 56}

Paul M Ridker ^{23, 280}

Frits R. Rosendaal ¹⁷

Timo E Saaristo ^{281, 282}

Manjinder Sandhu ²⁸³

Jouko Saramies ²⁸⁴

Neil Schneiderman ²⁸⁵

Peter Schwarz ^{93, 136, 286}

Laura J. Scott ^{41, 42}

Elizabeth Selvin ³⁷

Peter Sever ²⁶⁰

Xiao-Ou Shu ⁸⁷

P. Eline Slagboom ¹³¹

Kerrin S Small ⁹⁰

Blair H. Smith ²⁸⁷

Harold Snieder ³⁵

Tamar Sofer ^{234, 288}

Thorkild I. A. Sørensen ^{7, 8, 49, 289}

Tim D. Spector ⁹⁰

Alice Stanton ²⁹⁰

Claire J. Steves ^{90, 291}

Michael Stumvoll ¹³⁴

Liang Sun ²⁸

Yasuharu Tabara ⁷⁹

E Shyong Tai ^{40, 172, 292}

Nicholas J. Timpson ^{7, 8}

Anke Tönjes ¹³⁴

Jaakko Tuomilehto ^{293, 294, 295}

Teresa Tusie ^{77, 296}

Matti Uusitupa ²⁹⁷

Veronique Vitart ¹⁹⁴

Peter Vollenweider ²⁹⁸

Tanja G. M. Vrijkotte ¹²⁴

Lynne E. Wagenknecht ²⁹⁹

Mark Walker ³⁰⁰

Ya X Wang ²⁵⁰

Nick J. Wareham ⁹

Richard M. Watanabe ^{120, 121, 221}

Hugh Watkins ^{12, 146}

Wen B. Wei ³⁰¹

Ananda R Wickremasinghe ³⁰²

Gonneke Willemsen ^{26, 27}

James F. Wilson ^{80, 194}

Tien Yin Wong ^{57, 189}

Jer-Yuarn Wu ⁵⁹

Anny H. Xiang ³⁰³

Lisa R Yanek ²¹⁰

Loïc Yengo ³⁰⁴

Mitsuhiro YOKOTA ³⁰⁵

Eleftheria Zeggini ^{2, 43, 306}

Wei Zheng ⁸⁷

Alan B. Zonderman ⁶¹

Jerome I. Rotter ²¹

Anna L. Gloyn ^{11, 12, 178, 307}

Mark I McCarthy ^{11, 12, 178, 272, 308}

Josée Dupuis ²⁵

James B. Meigs ^{107, 234, 309}

Robert A Scott ⁹

Inga Prokopenko ^{22, 29}

Aaron Leong ^{226, 310, 311}

Ching-Ti Liu ²⁵

Stephen C.J. Parker ^{6, 312}

Karen L Mohlke ³

Claudia Langenberg ⁹

Eleanor Wheeler ^{2, 9}

Andrew P Morris ^{12, 313, 314, 315}

I Barroso ^{1, 2, 9}

Скрыть аффилиации авторов Показать аффилиации авторов: 315 аффилиаций

Exeter Centre of Excellence for Diabetes Research (EXCEED), Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK |

Department of Human Genetics, Wellcome Sanger Institute, Cambridge, UK |

Department of Genetics, University of North Carolina, Chapel Hill, USA |

⁴

Department of Biostatistics and Epidemiology, University of Massachusetts, Amherst, USA |

⁵

Inserm, Univ Brest, EFS, UMR 1078, GGB, Brest, France

Французский институт здравоохранения и медицинских исследований

Университет Западной Бретани

⁶

Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, USA |

⁷

MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK |

⁸

Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK |

⁹

MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK |

¹⁰

Department of Biostatistics, School of Public Health, Shandong University, Jinan, China |

¹¹

Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK |

¹²

Wellcome Centre for Human genetics, University of Oxford, Oxford, UK |

¹³

Laboratory for Genomics of Diabetes and Metabolism, RIKEN Centre for Integrative Medical Sciences, Yokohama, Japan |

¹⁴

Medical Research Council Human Genetics Unit, Institute for Genetics and Molecular Medicine, Edinburgh, UK |

¹⁵

Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia |

¹⁶

COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark |

¹⁷

Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands |

¹⁸

Department of Epidemiology, Brown University School of Public Health, Brown University, Providence, USA |

¹⁹

Department of Biomedical Sciences, City University of Hong Kong, Hong Kong SAR, China |

²⁰

Department of Electrical Engineering, City University of Hong Kong, Hong Kong SAR, China |

²¹

The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, USA |

²²

Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK |

²³

Division of Preventive Medicine, Brigham and Women’s Hospital, Boston, USA |

²⁴

Department of genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands |

²⁵

Department of biostatistics, Boston University School of Public Health, Boston, USA |

²⁶

Department of Biological Psychology, Faculty of Behaviour and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands |

²⁷

Amsterdam Public Health Research Institute, Amsterdam University Medical Center, Amsterdam, the Netherlands |

²⁸

CAS Key Laboratory of Nutrition, Metabolism and Food safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China

Университет Китайской академии наук

Шанхайский институт питания и здоровья, Китайская академия наук

²⁹

Section of Statistical Multi-omics, Department of Clinical and Experimental research, University of Surrey, Guildford, UK |

³⁰

Department of Biostatistics, University of Washington, Seattle, USA |

³¹

SYNLAB Academy, SYNLAB Holding Deutschland GmbH, Mannheim, Germany |

³²

Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University Graz, Graz, Austria |

³³

Vth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, Heidelberg University, Mannheim, Baden-Württemberg, Germany

Гейдельбергский университет имени Рупрехта и Карла

Мангеймский университет

³⁴

Department of Economics, Metropolitan Autonomous University, Mexico City, Mexico

Столичный автономный университет

Автономный университет Мехико

³⁵

Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands |

³⁶

CVD Genetic Epidemiology Computational Laboratory, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, USA |

³⁷

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA |

³⁸

The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, USA |

³⁹

HPI Digital Health Center, Digital Health and Personalized Medicine, Hasso Plattner Institute, Potsdam, Germany |

⁴⁰

Saw Swee Hock School of Public Health, National Univeristy of Singapore and National University Health System, Singapore, Singapore |

⁴¹

Center for Statistical Genetics, University of Michigan, Ann Arbor, USA |

⁴²

Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, USA |

⁴³

Institute of Translational Genomics, Helmholtz Zentrum München–German Research Center for Environmental Health, Neuherberg, Germany |

⁴⁴

School of Medicine and Public Health, College of Health, Medicine and Wellbeing, The University of Newcastle, Newcastle, Australia |

⁴⁵

Department of Epidemiology and Biostatistics, Imperial College London, London, UK |

⁴⁶

Department of Cardiology, Ealing Hospital, London North West Healthcare NHS Trust, London, UK |

⁴⁷

Steno diabetes Center Copenhagen, Gentofte, Denmark |

⁴⁸

The Bioinformatics Centre, Department of Biology, University of Copenhagen, Copenhagen, Denmark |

⁴⁹

Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

Университет Копенгагена

Ново Нордиск

⁵⁰

Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, USA |

⁵¹

Department of Medicine, Cardiovascular Health Research Unit, University of Washington, Seattle, USA |

⁵²

Metabolism Program, Program in Medical and Population Genetics, Broad Institute, Cambridge, USA |

⁵³

Department of Clinical Pharmacology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK |

⁵⁴

NIHR Barts Cardiovascular Biomedical Research Centre, Queen Mary University of London, London, UK |

⁵⁵

Department of Medicine, Sleep and Circadian Disorders, Brigham and Women’s Hospital, Boston, USA |

⁵⁶

Department of Medicine, Sleep Medicine, Harvard Medical School, Boston, USA |

⁵⁷

Ocular Epidemiology, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore

Сингапурский институт глазных исследований

Сингапурский национальный глазной центр

⁵⁸

Department of Ophthalmology, National University of Singapore and National University Health System, Singapore, Singapore |

⁵⁹

Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan |

⁶⁰

Department of Epidemiology, The Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla, USA |

⁶¹

Laboratory of Epidemiology and Population Sciences, National Institute On Aging, National Institutes of Health, Baltimore, USA |

⁶²

Institute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan |

⁶³

Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands |

⁶⁴

Department of Statistics, University of North Carolina at Chapel Hill, Chapel Hill, USA |

⁶⁵

Institute of Cardiovascular Science, University College London, London, UK |

⁶⁶

Uganda Medical Informatics Centre (UMIC), MRC/UVRI and London School of Hygiene & Tropical Medicine (Uganda Research Unit), Entebbe, Uganda |

⁶⁷

London School of Hygiene & Tropical Medicine, London, UK |

⁶⁸

H3Africa Bioinformatics Network (H3ABioNet) Node, Centre for Genomics Research and Innovation, NABDA/FMST, Abuja, Nigeria |

⁶⁹

Bioinfosol, Sevilla, Spain |

⁷⁰

Molecular Epidemiology and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala, Sweden |

⁷¹

Department of Statistics, The University of Auckland, Science Center, Auckland, New Zealand |

⁷²

Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil |

⁷³

Department of Medicine, Epidemiology, Vanderbilt University Medical Center, Nashville, USA |

⁷⁴

Department of Epidemiology, Tulane University Obesity Research Center, Tulane University, New Orleans, USA |

⁷⁵

Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China |

⁷⁶

Molecular Biology and Genomic Medicine Unit, National Council for Science and Technology, Mexico City, Mexico |

⁷⁷

Molecular Biology and Genomic Medicine Unit, National Institute of Medical Sciences and Nutrition, Mexico City, Mexico |

⁷⁸

Division of Genome Science, Department of Precision Medicine, National Institute of Health, Cheongju, South Korea |

⁷⁹

Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan |

⁸⁰

Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK |

⁸¹

Centre for Cardiovascular Sciences, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK |

⁸²

Department of Medicine, Divison of Biomedical Informatics and Personalized Medicine, University of Colorado Anschutz Medical Campus, Denver, USA |

⁸³

Department of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, USA |

⁸⁴

Department of Medicine, Division of Nephrology and Hypertension, University of Utah, Salt Lake City, USA |

⁸⁵

Nuffield Department of Population Health, University of Oxford, Oxford, UK |

⁸⁶

Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore |

⁸⁷

Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, USA |

⁸⁸

Department of Clinical Science, Center for Diabetes Research, University of Bergen, Bergen, Norway |

⁸⁹

Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, Malmo, Sweden |

⁹⁰

Department of Twin Research and Genetic Epidemiology, School of Life Course Sciences, King’s College London, London, UK |

⁹¹

NIHR Biomedical Research Centre, Guy’s and St Thomas’ NHS Foundation Trust, London, UK |

⁹²

Institute of Epidemiology, Research Unit of Molecular Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, Neuherberg, Germany |

⁹³

German Center for Diabetes Research (DZD), Neuherberg, Germany |

⁹⁴

Department of Medicine, Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, USA |

⁹⁵

Public Health Informatics Unit, Department of Integrated Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan |

⁹⁶

Institute for Biomedicine, EURAC Research, Bolzano, Italy |

⁹⁷

Department of Internal Medicine, section of gerontology and geriatrics, Leiden University Medical Center, Leiden, The Netherlands |

⁹⁸

Istituto Di Ricerca Genetica E Biomedica (IRGB), Consiglio Nazionale Delle Ricerche (CNR), Monserrato, Italy |

⁹⁹

The Mindich Child Health and Development Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, USA |

¹⁰⁰

Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, USA |

¹⁰¹

Center for Public Health Genomics, University of Virginia, Charlottesville, USA |

¹⁰²

Department of Public Health Sciences, University of Virginia, Charlottesville, USA |

¹⁰³

Department of Computational Biology, University of Lausanne, Lausanne, Switzerland |

¹⁰⁴

Swiss Institute of Bioinformatics, Lausanne, Switzerland |

¹⁰⁵

Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, USA

Гарвардский университет

Массачусетская больница общего профиля

¹⁰⁶

Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, USA |

¹⁰⁷

Program in Medical and Population Genetics, Broad Institute, Cambridge, USA |

¹⁰⁸

Department of Cell and Molecular Biology, National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Uppsala University, Uppsala, Sweden |

¹⁰⁹

Department of Biostatistics, University of Michigan, Ann Arbor, USA |

¹¹⁰

Icelandic Heart Association, Kopavogur, Iceland |

¹¹¹

Institute of Health and WellBeing, University of Glasgow, Glasgow, UK |

¹¹²

Department of Medicine Solna, Cardiovascular Medicine, Karolinska Institutet, Stockholm, Sweden |

¹¹³

National Center For Global Health and Medicine, Tokyo, Japan |

¹¹⁴

Department of Cardiology, Leiden University Medical Center, Leiden, The NetherLands |

¹¹⁵

Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands |

¹¹⁶

Genomics plc, Oxford, UK |

¹¹⁷

Center of Pediatric Research, University Children’s Hospital Leipzig, University of Leipzig Medical Center, Leipzig, Germany |

¹¹⁸

Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong university of Science and Technology, Wuhan, China |

¹¹⁹

Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore

Агентство науки, технологий и исследований

Институт генома Сингапура

¹²⁰

Department of Preventive Medicine, Keck School of Medicine of University of Southern California, Los Angeles, USA |

¹²¹

University of Southern California Diabetes and Obesity Research Institute, Keck School of Medicine of University of Southern California, Los Angeles, USA |

¹²²

Department of Community Medicine, Faculty of Health Sciences, UIT the Arctic University of Norway, Tromsø, Norway |

¹²³

MRC Unit for Lifelong Health and Ageing at University College London, London, UK |

¹²⁴

Department of Public Health, Amsterdam Public Health Research Institute, Amsterdam University Medical Center, Amsterdam, the Netherlands |

¹²⁵

Department of Clinical Epidemiology, Biostatistics, and Bioinformatics, Amsterdam Public Health Research Institute, Amsterdam University Medical Center, Amsterdam, the Netherlands |

¹²⁶

Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, UK |

¹²⁷

Department of Nutrition, Exercise, and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark |

¹²⁸

Department of Internal medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands |

¹²⁹

Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy |

¹³⁰

Centro Cardiologico Monzino, IRCCS, Milan, Italy

Научные институты госпитализации и лечения

Кардиологический центр Монзино

¹³¹

Department of Biomedical Data Sciences, Molecular Epidemiology, Leiden University Medical Center, Leiden, the Netherlands |

¹³²

Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, USA |

¹³³

Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, USA |

¹³⁴

Medical Department III–Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany |

¹³⁵

Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institues of Health, Bethesda, USA |

¹³⁶

Department for Prevention and Care of Diabetes, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany

Дрезденский технический университет

Университетская больница Карла Густава Каруса

¹³⁷

Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, USA |

¹³⁸

Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK |

¹³⁹

Usher institute, University of Edinburgh, Edinburgh, UK |

¹⁴⁰

Department of Internal medicine, National Taiwan University Hospital, Taipei, Taiwan |

¹⁴¹

Graduate Institute of Medical Genomics and Proteomics, National Taiwan University, Taipei, Taiwan |

¹⁴²

Department of Nutrition, Gillings School of Global Public health, University of North Carolina, Chapel Hill, USA |

¹⁴³

Department of Population Science and Experimental Medicine, Institute of Cardiovascular Science, University College London, London, UK |

¹⁴⁴

Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University of Athens, Athens, Greece |

¹⁴⁵

Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China |

¹⁴⁶

Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK |

¹⁴⁷

Department of Psychiatry, Interdisciplinary Center Psychopathy and Emotion Regulation, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands |

¹⁴⁸

Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research At Heinrich Heine University Düsseldorf, Düsseldorf, Germany

Немецкий центр диабета

Дюссельдорфский университет имени Генриха Гейне

¹⁴⁹

Division of Endocrinology and Diabetology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany |

¹⁵⁰

German Center for Diabetes Research (DZD), Düsseldorf, Germany |

¹⁵¹

Internal Medicine, Endocrine and Metabolism, Tri-Service General Hospital, Taipei, Taiwan |

¹⁵²

School of Medicine, National Defense Medical Center, Taipei, Taiwan |

¹⁵³

Internal Medicine, Endocrinology, Diabetes and Metabolism, Diabetes and Metabolism Research Center, The Ohio State University Wexner Medical Center, Columbus, USA |

¹⁵⁴

Department of Environmental and Preventive Medicine, Jichi Medical University School of Medicine, Shimotsuke, Japan |

¹⁵⁵

Department of Anti-aging Medicine, Ehime University Graduate School of Medicine, Toon, Japan |

¹⁵⁶

National Institute of Public health, University of Southern Denmark, Odense, Denmark |

¹⁵⁷

Department of Medicine, Endocrinology, Diabetes and Metabolism, Johns Hopkins University School of Medicine, Baltimore, USA |

¹⁵⁸

Clinical Diabetes, Endocrinology and Metabolism, Translational Research and Cellular Therapeutics, Beckman Research Institute of the City of Hope, Duarte, USA |

¹⁵⁹

Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Suita, Japan |

¹⁶⁰

Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Japan |

¹⁶¹

Department of Public Health, University of Split School of Medicine, Split, Croatia |

¹⁶²

Institute of Biomedicine, Bioinformatics Center, Univeristy of Eastern Finland, Kuopio, Finland |

¹⁶³

Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland

Университет восточной Финляндии

Больница университета Куопио

¹⁶⁴

USC-Office of Population Studies Foundation, University of San Carlos, Cebu City, the Philippines |

¹⁶⁵

Department of Anthropology, Sociology and History, University of San Carlos, Cebu City, the Philippines |

¹⁶⁶

State Key Laboratory of Oncogene and Related Genes and Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China |

¹⁶⁷

Center for Geriatrics and Gerontology, Taichung Veterans General Hospital, Taichung, Taiwan |

¹⁶⁸

National Defense Medical Center, National Yang-Ming University, Taipei, Taiwan

Национальный университет Ян Мин Цзяотун

Медицинский центр национальной обороны

¹⁶⁹

Diabetes Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland |

¹⁷⁰

Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark |

¹⁷¹

Department of Clinical Medicine, Faculty of Health and Medical sciences, University of Copenhagen, Copenhagen, Denmark |

¹⁷²

Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore |

¹⁷³

Department of Medicine, University of Texas Health Sciences Center, San Antonio, USA |

¹⁷⁴

Department of Internal Medicine, Aichi Gakuin University School of Dentistry, Nagoya, Japan |

¹⁷⁵

Department of Diabetes, Diabetes, and Nutritional Sciences, James Black Centre, King’s College London, London, UK |

¹⁷⁶

Department of Functional Pathology, Shimane University School of Medicine, Izumo, Japan |

¹⁷⁷

Department of Medicine and Pharmacology, New York Medical College School of Medicine, Valhalla, USA |

¹⁷⁸

Oxford NIHR Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK |

¹⁷⁹

Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, USA |

¹⁸⁰

Department of Geriatric Medicine and Neurology, Ehime University Graduate School of Medicine, Toon, Japan |

¹⁸¹

Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, Neuherberg, Germany |

¹⁸²

Institute for Medical Information Processing, Biometry and Epidemiology, Ludwig-Maximilians University Munich, Munich, Germany |

¹⁸³

Gen-Info, Zagreb, Croatia |

¹⁸⁴

Department of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, USA |

¹⁸⁵

Genetics and Pharmacogenomics, Merck Sharp & Dohme, Kenilworth, USA |

¹⁸⁶

Department of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, USA |

¹⁸⁷

Department of Internal medicine, Erasmus Medical Center, Rotterdam, The Netherlands |

¹⁸⁸

Centre for Global Health, The Usher Institute, University of Edinburgh, Edinburgh, UK |

¹⁸⁹

Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore |

¹⁹⁰

BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK |

¹⁹¹

Department of Experimental Diabetology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany |

¹⁹²

Department of Genetics, Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center at Shanghai (CHGC) and Shanghai Academy of Science & Technology (SAST), Shanghai, China |

¹⁹³

Sarepta Therapeutics, Cambridge, USA |

¹⁹⁴

Medical Research Council Human Genetics Unit, Institute for Genetics and Cancer, University of Edinburgh, Edinburgh, UK |

¹⁹⁵

Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, USA |

¹⁹⁶

Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland |

¹⁹⁷

Department of Medicine, Bornholms Hospital, Rønne, Denmark |

¹⁹⁸

Department of Internal Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, the Netherlands |

¹⁹⁹

Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands |

²⁰⁰

Department of Human genetics, Leiden University Medical Center, Leiden, The Netherlands |

²⁰¹

Department of Human Biology, University of Split School of Medicine, Split, Croatia |

²⁰²

Carolina Population Center, University of North Carolina, Chapel Hill, USA |

²⁰³

Department of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion, Mexico City, Mexico |

²⁰⁴

Unidad de Investigación de Enfermedades Metabólicas, Instituto Nacional de Ciencias Médicas y Nutrición and Tec Salud, Mexico City, Mexico |

²⁰⁵

Instituto Tecnológico y de Estudios Superiores de Monterrey Tec Salud, Monterrey, Mexico |

²⁰⁶

Department of Medical Genomics, Pfizer/University of Granada/Andalusian Government Center for Genomics and Oncological Research (GENYO), Granada, Spain |

²⁰⁷

Institute for Environmental Medicine, Chronic Inflammatory Diseases, Karolinska Institutet, Solna, Sweden |

²⁰⁸

Department of Genetics, Division of Statistical Genomics, Washington University School of Medicine, St Louis, USA |

²⁰⁹

Clinical and Health Services Research, National Institute on Minority Health and Health Disparities, Bethesda, USA |

²¹⁰

Department of Medicine, General Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, USA |

²¹¹

Medical School, Royal Perth Hospital Unit, University of Western Australia, Perth, Australia

Университет Западной Австралии

Королевская больница Перта

²¹²

Department of Integrative Biomedical Sciences, University of Cape Town, Cape Town, South Africa |

²¹³

Aberdeen Centre for Health Data Science, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, UK |

²¹⁴

Human Genetics Center, School of Public Health, The University of Texas Health Science Center At Houston, Houston, USA |

²¹⁵

Human genome Sequencing Center, Baylor College of Medicine, Houston, USA |

²¹⁶

Division of Endocrinology and Diabetes, Graduate School of Molecular Endocrinology and Diabetes, University of Ulm, Ulm, Germany |

²¹⁷

LKC School of Medicine, Nanyang Technological University, Singapore and Imperial College London, UK, Singapore, Singapore |

²¹⁸

Hasso Plattner Institute for Digital Health at Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, USA |

²¹⁹

Digital Health Center, Hasso Plattner Institut, University Potsdam, Potsdam, Germany

Институт цифровой инженерии Хассо Платтнера

Потсдамский университет

²²⁰

Department of Medicine, Keck School of Medicine of University of Southern California, Los Angeles, USA |

²²¹

Department of Physiology and Neuroscience, Keck School of Medicine of University of Southern California, Los Angeles, USA |

²²²

INSERM UMR 1283/CNRS UMR 8199, European Institute for Diabetes (EGID), Université de Lille, Lille, France

Университет Лилля

Французский институт здравоохранения и медицинских исследований

²²³

INSERM UMR 1283/CNRS UMR 8199, European Institute for Diabetes (EGID), Institut Pasteur de Lille, Lille, France

Институт Пастера в Лилле

Французский институт здравоохранения и медицинских исследований

²²⁴

Imperial College Healthcare NHS Trust, Imperial College London, London, UK |

²²⁵

MRC-PHE Centre for Environment and Health, Imperial College London, London, UK |

²²⁶

HARVARD Medical school, Boston, USA |

²²⁷

Department of Medicine, Jackson Heart Study, University of Mississippi Medical Center, Jackson, USA |

²²⁸

Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University of Athens, Kallithea, Greece |

²²⁹

Department of clinical sciences, Lund University, Malmö, Sweden |

²³⁰

Laboratory of Epidemiology and Population Sciences, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, USA |

²³¹

CNR Institute of Clinical Physiology, Pisa, Italy |

²³²

Intramural Research Program, National Institute of Aging, Baltimore, USA |

²³³

Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, USA |

²³⁴

Department of medicine, Harvard Medical School, Boston, USA |

²³⁵

Department of Public Health and Clinical Medicine, Umeå University, UMEÅ, Sweden |

²³⁶

Department of Genomics of Common Disease, Imperial College London, London, UK |

²³⁷

Department of Medicine, Cardiovascular Medicine, Karolinska Institutet, Stockholm, Sweden |

²³⁸

Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, Los Angeles, USA |

²³⁹

Diabetes Centre, Lund University, Lund, Sweden |

²⁴⁰

Finnish Institute of Molecular Medicine, Helsinki University, Helsinki, Finland

Хельсинкский университет

Институт молекулярной медицины Финляндии

²⁴¹

Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland |

²⁴²

Department of Epidemiology, Cardiovascular Health Research Unit, University of Washington, Seattle, USA |

²⁴³

Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford University, Stanford, USA |

²⁴⁴

Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, USA |

²⁴⁵

Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK |

²⁴⁶

Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland |

²⁴⁷

Unit of Primary Health Care, Oulu Univerisity Hospital, OYS, Oulu, Finland |

²⁴⁸

Department of Life Sciences, College of Health and Life Sciences, Brunel University London, London, UK |

²⁴⁹

Department of Ophthalmology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany

Гейдельбергский университет имени Рупрехта и Карла

Мангеймский университет

²⁵⁰

Beijing Institute of Ophthalmology, Beijing Ophthalmology and Visual Science Key Lab, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China |

²⁵¹

Institute of Molecular and Clinical Ophthalmology Basel IOB, Basel, Switzerland |

²⁵²

Netherlands Heart Institute, Utrecht, the Netherlands |

²⁵³

MRC/UVRI and LSHTM (Uganda Research Unit), Entebbe, Uganda |

²⁵⁴

Faculty of Medicine, Institute of Health Sciences, University of Oulu, Oulu, Finland |

²⁵⁵

Unit of General Practice, Oulu University Hospital, Oulu, Finland |

²⁵⁶

Department of epidemiology and public health, University College London, London, UK |

²⁵⁷

Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland |

²⁵⁸

Department of Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland |

²⁵⁹

Minerva Foundation Institute for Medical Research, Helsinki, Finland |

²⁶⁰

National Heart and Lung Institute, Imperial College London, London, UK |

²⁶¹

IFB Adiposity Diseases, University of Leipzig Medical Center, Leipzig, Germany |

²⁶²

Institute For Social and Economic Research, University of Essex, Colchester, UK |

²⁶³

University Institute of Primary Care and Public Health, Division of Biostatistics, University of Lausanne, Lausanne, Switzerland |

²⁶⁴

Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland |

²⁶⁵

Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland |

²⁶⁶

Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland |

²⁶⁷

Institute of Environmental Medicine, Cardiovascular and Nutritional Epidemiology, Karolinska Institutet, Stockholm, Sweden |

²⁶⁸

Department of Medical Sciences, University of Uppsala, Uppsala, Sweden |

²⁶⁹

Big Data Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK |

²⁷⁰

Nuffield Department of Women’s and Reproductive health, University of Oxford, Oxford, UK |

²⁷¹

Department of Medical Epidemiology and Biostatistics and the Swedish Twin Registry, Karolinska Institutet, Stockholm, Sweden |

²⁷²

Genentech, South San Francisco, USA |

²⁷³

Department of Public health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands |

²⁷⁴

Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK |

²⁷⁵

Division of Population Health and Genomics, School of Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK |

²⁷⁶

Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK |

²⁷⁷

Department of Health Services, Cardiovascular Health Research Unit, University of Washington, Seattle, USA |

²⁷⁸

Department of Epidemiology, Tulane University School of Public health and Tropical Medicine, New Orleans, USA |

²⁷⁹

Department of Pediatrics, Genetic and Genomic Medicine, University of California, Irvine, Irvine, USA |

²⁸⁰

Havard Medical School, Boston, USA |

²⁸¹

Tampere, Finnish Diabetes Association, Tampere, Finland |

²⁸²

Pirkanmaa Hospital District, Tampere, Finland |

²⁸³

Department of Medicine, University of Cambridge, Cambridge, UK |

²⁸⁴

South Karelia Central Hospital, Lappeenranta, Finland |

²⁸⁵

Department of Psychology, University of Miami, Miami, USA |

²⁸⁶

Paul Langerhans Institute Dresden of the Helmholtz Center Munich, University Hospital and Faculty of Medicine, Dresden, Germany |

²⁸⁷

Division of Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK |

²⁸⁸

Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital, Boston, USA |

²⁸⁹

Department of Public Health, Section of Epidemiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark |

²⁹⁰

Department of Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland |

²⁹¹

Department of Ageing and Health, Guy’s and St Thomas’ NHS Foundation Trust, London, UK |

²⁹²

Cardiovascular and Metabolic Disease Signature Research Program, Duke-NUS Medical School, Singapore, Singapore |

²⁹³

Department of Public Health Solutions, National Institute for Health and Welfare, Helsinki, Finland |

²⁹⁴

Department of Public health, University of Helsinki, Helsinki, Finland |

²⁹⁵

Saudi Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia |

²⁹⁶

Department of Genomic Medicine and Environmental Toxicology, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico |

²⁹⁷

Department of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland |

²⁹⁸

Department of Medicine, Internal Medicine, Lausanne university hospital (CHUV), Lausanne, Switzerland |

²⁹⁹

Department of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, USA |

³⁰⁰

Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, UK |

³⁰¹

Beijing Tongren Eye Center, Beijing key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology & Visual Sciences Key Lab, Beijing Tongren Hospital, Capital Medical University, Beijing, China |

³⁰²

Department of Public Health, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka |

³⁰³

Department of Research and Evaluation, Kaiser Permanente of Southern California, Pasadena, USA |

³⁰⁴

Institute for Molecular Bioscience, the University of Queensland, St Lucia, Australia |

³⁰⁵

Kurume University School of Medicine, Kurume, Japan |

³⁰⁶

TUM School of Medicine, Technical University of Munich and Klinikum Rechts Der Isar, Munich, Germany

Мюнхенский технический университет

Больница Рехтс дер Изар

Мюнхенская клиника

³⁰⁷

Department of Pediatrics, Division of Endocrinology, Stanford School of Medicine, Stanford, USA |

³⁰⁸

Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK |

³⁰⁹

Department of Medicine, Division of General Internal Medicine, Massachusetts General Hospital, Boston, USA |

³¹⁰

Department of Medicine, General Internal Medicine, Massachusetts General Hospital, Boston, USA |

³¹¹

Department of Medicine, Diabetes Unit and Endocrine Unit, Massachusetts General Hospital, Boston, USA |

³¹²

Department of Human Genetics, University of Michigan, Ann Arbor, USA |

³¹³

Centre for Genetics and Genomics Versus Arthritis, Division of Musculoskeletal and Dermatological Sciences, The University of Manchester, Manchester, UK |

³¹⁴

Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, The University of Manchester, Manchester, UK |

³¹⁵

Department of Biostatistics, University of Liverpool, Liverpool, UK |

Тип публикации: Journal Article

Дата публикации: 2021-05-31

Springer Nature

Nature Genetics

scimago Q1

wos Q1

БС1

SJR: 16.586

CiteScore: 45.1

Impact factor: 29.0

ISSN: 10614036, 15461718

DOI: 10.1038/s41588-021-00852-9

Скопировать DOI

PubMed ID: 34059833

Genetics

Краткое описание

Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic health. To date, most genetic studies of glycemic traits have focused on individuals of European ancestry. Here we aggregated genome-wide association studies comprising up to 281,416 individuals without diabetes (30% non-European ancestry) for whom fasting glucose, 2-h glucose after an oral glucose challenge, glycated hemoglobin and fasting insulin data were available. Trans-ancestry and single-ancestry meta-analyses identified 242 loci (99 novel; P < 5 × 10−8), 80% of which had no significant evidence of between-ancestry heterogeneity. Analyses restricted to individuals of European ancestry with equivalent sample size would have led to 24 fewer new loci. Compared with single-ancestry analyses, equivalent-sized trans-ancestry fine-mapping reduced the number of estimated variants in 99% credible sets by a median of 37.5%. Genomic-feature, gene-expression and gene-set analyses revealed distinct biological signatures for each trait, highlighting different underlying biological pathways. Our results increase our understanding of diabetes pathophysiology by using trans-ancestry studies for improved power and resolution. A trans-ancestry meta-analysis of GWAS of glycemic traits in up to 281,416 individuals identifies 99 novel loci, of which one quarter was found due to the multi-ancestry approach, which also improves fine-mapping of credible variant sets.

Найдено

3 цитирования

Марселли Лорелла

167 публикаций, 11 269 цитирований, 8 рецензий

Индекс Хирша: 56

Пизанский университет

2 цитирования

Пьемонти Лоренцо

373 публикации, 20 495 цитирований, 157 рецензий

Индекс Хирша: 71

Вита-Салюте Университет Сан-Раффаэле

Больница Сан-Раффаэле

Области научных интересов

Диабет

Регенеративная медицина

1 цитирование

Федриго Оливиер

62 публикации, 5 471 цитирование

Индекс Хирша: 23

Рокфеллеровский университет

Ноттингемский университет

Международный институт исследований животноводства (Кения)

1 цитирование

Барабаш Ана

93 публикации, 2 755 цитирований

Индекс Хирша: 26

Сеть биомедицинских исследовательских центров диабета и связанных с ним метаболических заболеваний

Мадридский университет Комплутенсе

Научно-исследовательский институт здравоохранения клинической больницы Сан-Карлос

Клиническая больница Сан-Карлос

1 цитирование

Эмиль Якоб

6 публикаций, 170 цитирований

Индекс Хирша: 4

Университет Копенгагена

Ново Нордиск

Топ-30

Журналы

	5 10 15 20
Frontiers in Endocrinology	Frontiers in Endocrinology, 20, 3.26% Frontiers in Endocrinology 20 публикаций, 3.26%
Diabetologia	Diabetologia, 18, 2.94% Diabetologia 18 публикаций, 2.94%
Nature Communications	Nature Communications, 16, 2.61% Nature Communications 16 публикаций, 2.61%
Nature Genetics	Nature Genetics, 14, 2.28% Nature Genetics 14 публикаций, 2.28%
Diabetology and Metabolic Syndrome	Diabetology and Metabolic Syndrome, 14, 2.28% Diabetology and Metabolic Syndrome 14 публикаций, 2.28%
Scientific Reports	Scientific Reports, 13, 2.12% Scientific Reports 13 публикаций, 2.12%
medRxiv : the preprint server for health sciences	medRxiv : the preprint server for health sciences, 12, 1.96% medRxiv : the preprint server for health sciences 12 публикаций, 1.96%
Journal of Clinical Endocrinology and Metabolism	Journal of Clinical Endocrinology and Metabolism, 11, 1.79% Journal of Clinical Endocrinology and Metabolism 11 публикаций, 1.79%
Diabetes	Diabetes, 10, 1.63% Diabetes 10 публикаций, 1.63%
BMC Medicine	BMC Medicine, 9, 1.47% BMC Medicine 9 публикаций, 1.47%
Nutrients	Nutrients, 9, 1.47% Nutrients 9 публикаций, 1.47%
Diabetes, Obesity and Metabolism	Diabetes, Obesity and Metabolism, 9, 1.47% Diabetes, Obesity and Metabolism 9 публикаций, 1.47%
Cell Genomics	Cell Genomics, 8, 1.31% Cell Genomics 8 публикаций, 1.31%
American Journal of Human Genetics	American Journal of Human Genetics, 8, 1.31% American Journal of Human Genetics 8 публикаций, 1.31%
bioRxiv	bioRxiv, 8, 1.31% bioRxiv 8 публикаций, 1.31%
Communications Biology	Communications Biology, 7, 1.14% Communications Biology 7 публикаций, 1.14%
EBioMedicine	EBioMedicine, 7, 1.14% EBioMedicine 7 публикаций, 1.14%
Frontiers in Genetics	Frontiers in Genetics, 6, 0.98% Frontiers in Genetics 6 публикаций, 0.98%
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 6, 0.98% International Journal of Molecular Sciences 6 публикаций, 0.98%
Cardiovascular Diabetology	Cardiovascular Diabetology, 6, 0.98% Cardiovascular Diabetology 6 публикаций, 0.98%
Cell Metabolism	Cell Metabolism, 6, 0.98% Cell Metabolism 6 публикаций, 0.98%
Medicine (United States)	Medicine (United States), 6, 0.98% Medicine (United States) 6 публикаций, 0.98%
Frontiers in Nutrition	Frontiers in Nutrition, 5, 0.82% Frontiers in Nutrition 5 публикаций, 0.82%
Nature Metabolism	Nature Metabolism, 5, 0.82% Nature Metabolism 5 публикаций, 0.82%
Metabolites	Metabolites, 5, 0.82% Metabolites 5 публикаций, 0.82%
Nutrition, Metabolism and Cardiovascular Diseases	Nutrition, Metabolism and Cardiovascular Diseases, 5, 0.82% Nutrition, Metabolism and Cardiovascular Diseases 5 публикаций, 0.82%
Nature	Nature, 5, 0.82% Nature 5 публикаций, 0.82%
Human Molecular Genetics	Human Molecular Genetics, 5, 0.82% Human Molecular Genetics 5 публикаций, 0.82%
Circulation	Circulation, 4, 0.65% Circulation 4 публикации, 0.65%
	5 10 15 20

Издатели

	20 40 60 80 100 120 140 160 180 200
Springer Nature	Springer Nature, 182, 29.69% Springer Nature 182 публикации, 29.69%
Elsevier	Elsevier, 99, 16.15% Elsevier 99 публикаций, 16.15%
Cold Spring Harbor Laboratory	Cold Spring Harbor Laboratory, 92, 15.01% Cold Spring Harbor Laboratory 92 публикации, 15.01%
Frontiers Media S.A.	Frontiers Media S.A., 45, 7.34% Frontiers Media S.A. 45 публикаций, 7.34%
Wiley	Wiley, 35, 5.71% Wiley 35 публикаций, 5.71%
MDPI	MDPI, 34, 5.55% MDPI 34 публикации, 5.55%
Oxford University Press	Oxford University Press, 18, 2.94% Oxford University Press 18 публикаций, 2.94%
Ovid Technologies (Wolters Kluwer Health)	Ovid Technologies (Wolters Kluwer Health), 17, 2.77% Ovid Technologies (Wolters Kluwer Health) 17 публикаций, 2.77%
American Diabetes Association	American Diabetes Association, 14, 2.28% American Diabetes Association 14 публикаций, 2.28%
The Endocrine Society	The Endocrine Society, 12, 1.96% The Endocrine Society 12 публикаций, 1.96%
Taylor & Francis	Taylor & Francis, 12, 1.96% Taylor & Francis 12 публикаций, 1.96%
SAGE	SAGE, 4, 0.65% SAGE 4 публикации, 0.65%
eLife Sciences Publications	eLife Sciences Publications, 4, 0.65% eLife Sciences Publications 4 публикации, 0.65%
Public Library of Science (PLoS)	Public Library of Science (PLoS), 3, 0.49% Public Library of Science (PLoS) 3 публикации, 0.49%
BMJ	BMJ, 3, 0.49% BMJ 3 публикации, 0.49%
American Association for the Advancement of Science (AAAS)	American Association for the Advancement of Science (AAAS), 3, 0.49% American Association for the Advancement of Science (AAAS) 3 публикации, 0.49%
Georg Thieme Verlag KG	Georg Thieme Verlag KG, 2, 0.33% Georg Thieme Verlag KG 2 публикации, 0.33%
Research Square Platform LLC	Research Square Platform LLC, 2, 0.33% Research Square Platform LLC 2 публикации, 0.33%
American Physiological Society	American Physiological Society, 2, 0.33% American Physiological Society 2 публикации, 0.33%
Association for Research in Vision and Ophthalmology (ARVO)	Association for Research in Vision and Ophthalmology (ARVO), 1, 0.16% Association for Research in Vision and Ophthalmology (ARVO) 1 публикация, 0.16%
American Chemical Society (ACS)	American Chemical Society (ACS), 1, 0.16% American Chemical Society (ACS) 1 публикация, 0.16%
Hindawi Limited	Hindawi Limited, 1, 0.16% Hindawi Limited 1 публикация, 0.16%
Pleiades Publishing	Pleiades Publishing, 1, 0.16% Pleiades Publishing 1 публикация, 0.16%
Publishing House Belorusskaya Nauka	Publishing House Belorusskaya Nauka, 1, 0.16% Publishing House Belorusskaya Nauka 1 публикация, 0.16%
American College of Physicians	American College of Physicians, 1, 0.16% American College of Physicians 1 публикация, 0.16%
American Society for Nutrition	American Society for Nutrition, 1, 0.16% American Society for Nutrition 1 публикация, 0.16%
F1000 Research	F1000 Research, 1, 0.16% F1000 Research 1 публикация, 0.16%
American Society of Nephrology	American Society of Nephrology, 1, 0.16% American Society of Nephrology 1 публикация, 0.16%
	20 40 60 80 100 120 140 160 180 200

Мы не учитываем публикации, у которых нет DOI.
Статистика публикаций обновляется еженедельно.

Вы ученый?

Создайте профиль, чтобы получать персональные рекомендации коллег, конференций и новых статей.

Войти с ORCID

Метрики

613

Цитировать

ГОСТ |

Цитировать

ГОСТ Скопировать

Chen J. et al. The trans-ancestral genomic architecture of glycemic traits // Nature Genetics. 2021. Vol. 53. No. 6. pp. 840-860.

ГОСТ со всеми авторами (до 50) Скопировать

Chen J. et al. The trans-ancestral genomic architecture of glycemic traits // Nature Genetics. 2021. Vol. 53. No. 6. pp. 840-860.

RIS |

Цитировать

RIS

BibTex |

Цитировать

BibTex (до 50 авторов) Скопировать

@article{2021_Chen,

author = {Ji Chen and Cassandra N Spracklen and Gaëlle Marenne and Arushi Varshney and Laura J. Corbin and Jian'an Luan and Sara M Willems and Ying Wu and Xiaoshuai Zhang and Momoko Horikoshi and Thibaud S. Boutin and Reedik Mägi and Johannes Waage and Ruifang Li-Gao and Kei Hang Katie Chan and JIE YAO and Mila D Anasanti and Audrey Y. Chu and Annique Claringbould and Jani Heikkinen and Jaeyoung Hong and Jouke-Jan Hottenga and Shaofeng Huo and Marika A. Kaakinen and Tin Louie and Winfried März and Hortensia Moreno-Macías and Anne Ndungu and Sarah C Nelson and Ilja M. Nolte and Kari E. North and Chelsea K Raulerson and Debashree Ray and Rebecca Rohde and Denis Rybin and Claudia Schurmann and Xueling Sim and Lorraine Southam and Isobel D. Stewart and Carol A. Wang and Yujie Wang and Peitao Wu and Weihua Zhang and Tarunveer S Ahluwalia and Emil V R Appel and Lawrence F. Bielak and Jennifer A. Brody and Noël P. Burtt and Claudia P. Cabrera and Brian E. Cade and others},

title = {The trans-ancestral genomic architecture of glycemic traits},

journal = {Nature Genetics},

year = {2021},

volume = {53},

publisher = {Springer Nature},

month = {may},

url = {https://doi.org/10.1038/s41588-021-00852-9},

number = {6},

pages = {840--860},

doi = {10.1038/s41588-021-00852-9}

}

MLA

Цитировать

MLA Скопировать

Chen, Ji, et al. “The trans-ancestral genomic architecture of glycemic traits.” Nature Genetics, vol. 53, no. 6, May. 2021, pp. 840-860. https://doi.org/10.1038/s41588-021-00852-9.

Издатель

Springer Nature

Журнал

Nature Genetics

scimago Q1

wos Q1

БС1

SJR

16.586

CiteScore

45.1

Impact factor

29.0

ISSN

10614036 (Print)

15461718 (Electronic)