SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes
Waradon Sungnak
1
,
Ni Huang
2
,
Christophe Becavin
3, 4
,
Marijn Berg
5
,
Rachel Queen
1, 6
,
Monika Litviňuková
1
,
Carlos Talavera-López
6
,
Henrike Maatz
7
,
Daniel Reichart
8, 9, 10
,
Fotios Sampaziotis
11
,
Kaylee B Worlock
11
,
6
Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany
|
9
Department of Medicine, Addenbrookes Hospital, Cambridge, UK
|
Publication type: Journal Article
Publication date: 2020-04-23
scimago Q1
wos Q1
SJR: 18.333
CiteScore: 82.4
Impact factor: 50.0
ISSN: 10788956, 1546170X, 17447933
PubMed ID:
32327758
General Biochemistry, Genetics and Molecular Biology
General Medicine
Abstract
We investigated SARS-CoV-2 potential tropism by surveying expression of viral entry-associated genes in single-cell RNA-sequencing data from multiple tissues from healthy human donors. We co-detected these transcripts in specific respiratory, corneal and intestinal epithelial cells, potentially explaining the high efficiency of SARS-CoV-2 transmission. These genes are co-expressed in nasal epithelial cells with genes involved in innate immunity, highlighting the cells’ potential role in initial viral infection, spread and clearance. The study offers a useful resource for further lines of inquiry with valuable clinical samples from COVID-19 patients and we provide our data in a comprehensive, open and user-friendly fashion at www.covid19cellatlas.org. An analysis of single-cell transcriptomics datasets from different tissues shows that ACE2 and TMPRSS2 are co-expressed in respiratory, corneal and intestinal epithelial cell populations, and that respiratory expression of ACE2 is associated with genes involved in innate immunity.
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Sungnak W. et al. SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes // Nature Medicine. 2020. Vol. 26. No. 5. pp. 681-687.
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Sungnak W., Huang N., Becavin C., Berg M., Queen R., Litviňuková M., Talavera-López C., Maatz H., Reichart D., Sampaziotis F., Worlock K. B., Yoshida M. SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes // Nature Medicine. 2020. Vol. 26. No. 5. pp. 681-687.
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TY - JOUR
DO - 10.1038/s41591-020-0868-6
UR - https://doi.org/10.1038/s41591-020-0868-6
TI - SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes
T2 - Nature Medicine
AU - Sungnak, Waradon
AU - Huang, Ni
AU - Becavin, Christophe
AU - Berg, Marijn
AU - Queen, Rachel
AU - Litviňuková, Monika
AU - Talavera-López, Carlos
AU - Maatz, Henrike
AU - Reichart, Daniel
AU - Sampaziotis, Fotios
AU - Worlock, Kaylee B
AU - Yoshida, Masahiro
PY - 2020
DA - 2020/04/23
PB - Springer Nature
SP - 681-687
IS - 5
VL - 26
PMID - 32327758
SN - 1078-8956
SN - 1546-170X
SN - 1744-7933
ER -
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BibTex (up to 50 authors)
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@article{2020_Sungnak,
author = {Waradon Sungnak and Ni Huang and Christophe Becavin and Marijn Berg and Rachel Queen and Monika Litviňuková and Carlos Talavera-López and Henrike Maatz and Daniel Reichart and Fotios Sampaziotis and Kaylee B Worlock and Masahiro Yoshida},
title = {SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes},
journal = {Nature Medicine},
year = {2020},
volume = {26},
publisher = {Springer Nature},
month = {apr},
url = {https://doi.org/10.1038/s41591-020-0868-6},
number = {5},
pages = {681--687},
doi = {10.1038/s41591-020-0868-6}
}
Cite this
MLA
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Sungnak, Waradon, et al. “SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes.” Nature Medicine, vol. 26, no. 5, Apr. 2020, pp. 681-687. https://doi.org/10.1038/s41591-020-0868-6.