Open Access

Scientific Reports, volume 7, issue 1, publication number 5

Lipidome determinants of maximal lifespan in mammals

Bozek Katarzyna ^{1, 2, 3}

Khrameeva Ekaterina E. ^{4, 5}

Reznick Jane ⁶

Omerbašić Damir ⁷

Bennett Nigel C ⁸

Lewin Gary ⁷

Azpurua Jorge ⁹

Gorbunova Vera ⁹

Seluanov Andrei ⁹

Regnard Pierrick ¹⁰

Wanert Fanelie ¹⁰

Marchal Julia ¹¹

Pifferi Fabien ¹¹

Aujard Fabienne ¹¹

Liu Zhen ¹²

Peng Shi ¹²

Pääbo Svante ¹

Schroeder Florian ¹³

Willmitzer Lothar ¹³

Giavalisco Patrick ¹³

Khaitovich Philipp ^{1, 3, 5}

Hide authors affiliations Show authors affiliations: 13 affiliations

Max Planck Institute For Evolutionary Anthropology, Leipzig, Germany |

Okinawa Institute of Science and Technology Graduate University, Kunigami-gun, Japan |

CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai, China |

⁴

Institute for Information Transmission Problems, Russian Academy of Sciences, Moscow, Russia |

⁵

Skoltech Center for Computational and Systems Biology, Skolkovo Institute for Science and Technology, Skolkovo, Russia |

⁶

Max-Delbrück Center for Molecular Medicine, Department of Zoology and Entomology, University of Pretoria, Pretoria, South Africa |

⁷

Max-Delbrück Center for Molecular Medicine, Berlin, Germany |

⁸

Department of Zoology and Entomology, University of Pretoria, Pretoria, South Africa |

⁹

University of Rochester, Rochester, USA |

¹⁰

SILABE, Primatology Center, University Louis Pasteur, Strasbourg, France |

¹¹

UMR 7179/CNRS-MNHN, Brunoy, France |

¹²

State Key laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China |

¹³

Max Planck Institute for Molecular Plant Physiology, Potsdam, Germany |

Publication type: Journal Article

Publication date: 2017-01-31

Springer Nature

Journal: Scientific Reports

Quartile SCImago

Quartile WOS

Impact factor: 4.6

ISSN: 20452322

DOI: 10.1038/s41598-017-00037-7

Copy DOI

PubMed ID: 28127055

Multidisciplinary

Abstract

Maximal lifespan of mammalian species, even if closely related, may differ more than 10-fold, however the nature of the mechanisms that determine this variability is unresolved. Here, we assess the relationship between maximal lifespan duration and concentrations of more than 20,000 lipid compounds, measured in 669 tissue samples from 6 tissues of 35 species representing three mammalian clades: primates, rodents and bats. We identify lipids associated with species’ longevity across the three clades, uncoupled from other parameters, such as basal metabolic rate, body size, or body temperature. These lipids clustered in specific lipid classes and pathways, and enzymes linked to them display signatures of greater stabilizing selection in long-living species, and cluster in functional groups related to signaling and protein-modification processes. These findings point towards the existence of defined molecular mechanisms underlying variation in maximal lifespan among mammals.

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Citations by journals

	1 2 3
Scientific Reports	Scientific Reports, 3, 6.52% Scientific Reports 3 publications, 6.52%
Molecular Biology and Evolution	Molecular Biology and Evolution, 2, 4.35% Molecular Biology and Evolution 2 publications, 4.35%
Aging	Aging, 2, 4.35% Aging 2 publications, 4.35%
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 2, 4.35% International Journal of Molecular Sciences 2 publications, 4.35%
Redox Biology	Redox Biology, 2, 4.35% Redox Biology 2 publications, 4.35%
Seminars in Cell and Developmental Biology	Seminars in Cell and Developmental Biology, 2, 4.35% Seminars in Cell and Developmental Biology 2 publications, 4.35%
Molecular Psychiatry	Molecular Psychiatry, 1, 2.17% Molecular Psychiatry 1 publication, 2.17%
Future Virology	Future Virology, 1, 2.17% Future Virology 1 publication, 2.17%
Current Opinion in Lipidology	Current Opinion in Lipidology, 1, 2.17% Current Opinion in Lipidology 1 publication, 2.17%
Molecules	Molecules, 1, 2.17% Molecules 1 publication, 2.17%
Life	Life, 1, 2.17% Life 1 publication, 2.17%
Frontiers in Physiology	Frontiers in Physiology, 1, 2.17% Frontiers in Physiology 1 publication, 2.17%
Frontiers in Cell and Developmental Biology	Frontiers in Cell and Developmental Biology, 1, 2.17% Frontiers in Cell and Developmental Biology 1 publication, 2.17%
Biogerontology	Biogerontology, 1, 2.17% Biogerontology 1 publication, 2.17%
Communications Biology	Communications Biology, 1, 2.17% Communications Biology 1 publication, 2.17%
Cell Stress and Chaperones	Cell Stress and Chaperones, 1, 2.17% Cell Stress and Chaperones 1 publication, 2.17%
GeroScience	GeroScience, 1, 2.17% GeroScience 1 publication, 2.17%
Journal of Ethnobiology and Ethnomedicine	Journal of Ethnobiology and Ethnomedicine, 1, 2.17% Journal of Ethnobiology and Ethnomedicine 1 publication, 2.17%
Current Research in Food Science	Current Research in Food Science, 1, 2.17% Current Research in Food Science 1 publication, 2.17%
Trends in Cell Biology	Trends in Cell Biology, 1, 2.17% Trends in Cell Biology 1 publication, 2.17%
Progress in Lipid Research	Progress in Lipid Research, 1, 2.17% Progress in Lipid Research 1 publication, 2.17%
Ageing Research Reviews	Ageing Research Reviews, 1, 2.17% Ageing Research Reviews 1 publication, 2.17%
Trends in Biochemical Sciences	Trends in Biochemical Sciences, 1, 2.17% Trends in Biochemical Sciences 1 publication, 2.17%
Neurochemistry International	Neurochemistry International, 1, 2.17% Neurochemistry International 1 publication, 2.17%
Journal of Evolutionary Biology	Journal of Evolutionary Biology, 1, 2.17% Journal of Evolutionary Biology 1 publication, 2.17%
New Phytologist	New Phytologist, 1, 2.17% New Phytologist 1 publication, 2.17%
ChemSusChem	ChemSusChem, 1, 2.17% ChemSusChem 1 publication, 2.17%
Semiconductor Science and Technology	Semiconductor Science and Technology, 1, 2.17% Semiconductor Science and Technology 1 publication, 2.17%
Journals of Gerontology - Series A Biological Sciences and Medical Sciences	Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 1, 2.17% Journals of Gerontology - Series A Biological Sciences and Medical Sciences 1 publication, 2.17%
	1 2 3

Citations by publishers

	2 4 6 8 10 12 14
Elsevier	Elsevier, 13, 28.26% Elsevier 13 publications, 28.26%
Springer Nature	Springer Nature, 9, 19.57% Springer Nature 9 publications, 19.57%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 5, 10.87% Multidisciplinary Digital Publishing Institute (MDPI) 5 publications, 10.87%
Wiley	Wiley, 4, 8.7% Wiley 4 publications, 8.7%
Oxford University Press	Oxford University Press, 3, 6.52% Oxford University Press 3 publications, 6.52%
Impact Journals	Impact Journals, 2, 4.35% Impact Journals 2 publications, 4.35%
Frontiers Media S.A.	Frontiers Media S.A., 2, 4.35% Frontiers Media S.A. 2 publications, 4.35%
Future Medicine	Future Medicine, 1, 2.17% Future Medicine 1 publication, 2.17%
Wolters Kluwer Health	Wolters Kluwer Health, 1, 2.17% Wolters Kluwer Health 1 publication, 2.17%
IOP Publishing	IOP Publishing, 1, 2.17% IOP Publishing 1 publication, 2.17%
Hindawi Limited	Hindawi Limited, 1, 2.17% Hindawi Limited 1 publication, 2.17%
Publishing House ABV Press	Publishing House ABV Press, 1, 2.17% Publishing House ABV Press 1 publication, 2.17%
	2 4 6 8 10 12 14

We do not take into account publications that without a DOI.
Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
Statistics recalculated weekly.

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Bozek K. et al. Lipidome determinants of maximal lifespan in mammals // Scientific Reports. 2017. Vol. 7. No. 1. 5

GOST all authors (up to 50) Copy

Bozek K., Khrameeva E. E., Reznick J., Omerbašić D., Bennett N. C., Lewin G., Azpurua J., Gorbunova V., Seluanov A., Regnard P., Wanert F., Marchal J., Pifferi F., Aujard F., Liu Z., Peng S., Pääbo S., Schroeder F., Willmitzer L., Giavalisco P., Khaitovich P. Lipidome determinants of maximal lifespan in mammals // Scientific Reports. 2017. Vol. 7. No. 1. 5

RIS |

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RIS Copy

TY - JOUR

DO - 10.1038/s41598-017-00037-7

UR - https://doi.org/10.1038%2Fs41598-017-00037-7

TI - Lipidome determinants of maximal lifespan in mammals

T2 - Scientific Reports

AU - Bozek, Katarzyna

AU - Khrameeva, Ekaterina E.

AU - Reznick, Jane

AU - Omerbašić, Damir

AU - Bennett, Nigel C

AU - Lewin, Gary

AU - Azpurua, Jorge

AU - Gorbunova, Vera

AU - Seluanov, Andrei

AU - Regnard, Pierrick

AU - Wanert, Fanelie

AU - Marchal, Julia

AU - Pifferi, Fabien

AU - Aujard, Fabienne

AU - Liu, Zhen

AU - Peng, Shi

AU - Pääbo, Svante

AU - Schroeder, Florian

AU - Willmitzer, Lothar

AU - Giavalisco, Patrick

AU - Khaitovich, Philipp

PY - 2017

DA - 2017/01/31 00:00:00

PB - Springer Nature

IS - 1

VL - 7

PMID - 28127055

SN - 2045-2322

ER -

BibTex

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BibTex Copy

@article{2017_Bozek,

author = {Katarzyna Bozek and Ekaterina E. Khrameeva and Jane Reznick and Damir Omerbašić and Nigel C Bennett and Gary Lewin and Jorge Azpurua and Vera Gorbunova and Andrei Seluanov and Pierrick Regnard and Fanelie Wanert and Julia Marchal and Fabien Pifferi and Fabienne Aujard and Zhen Liu and Shi Peng and Svante Pääbo and Florian Schroeder and Lothar Willmitzer and Patrick Giavalisco and Philipp Khaitovich},

title = {Lipidome determinants of maximal lifespan in mammals},

journal = {Scientific Reports},

year = {2017},

volume = {7},

publisher = {Springer Nature},

month = {jan},

url = {https://doi.org/10.1038%2Fs41598-017-00037-7},

number = {1},

doi = {10.1038/s41598-017-00037-7}

}

Found error?

Publisher

Springer Nature

Journal

Scientific Reports

Quartile SCImago

Quartile WOS

Impact factor

4.6

ISSN

20452322 (Print)

Labs

Laboratory of Molecular Neuroscience

Profiles

Khaitovich, Philipp E