Open Access

Scientific Reports

, volume 11 , issue 1 , publication number 14647

Skin tolerant inactivation of multiresistant pathogens using far-UVC LEDs

Johannes Glaab ¹

Neysha Lobo Ploch ¹

Hyun Kyong Cho ¹

Thomas Filler ¹

Heiko Gundlach ²

Martin Guttmann ³

Sylvia Hagedorn ¹

Silke B. Lohan ⁴

Frank Mehnke ^{3, 5}

Johannes Schleusener ⁴

Claudia Sicher ⁶

Luca Sulmoni ³

Tim Wernicke ³

Lucas Wittenbecher ¹

Ulrike Woggon ²

Paula Zwicker ⁶

Axel Kramer ⁶

Martina C. Meinke ⁴

Michael Kneissl ^{1, 3}

Markus Weyers ¹

Ulrike Winterwerber ¹

Sven Einfeldt ¹

Hide authors affiliations Show authors affiliations: 6 affiliations

Ferdinand-Braun-Institut gGmbH, Leibniz-Institut Für Höchstfrequenztechnik, Berlin, Germany |

Institut Für Optik Und Atomare Physik, Technische Universität Berlin, Berlin, Germany |

Institut Für Festkörperphysik, Technische Universität Berlin, Berlin, Germany |

⁴

Center of Experimental and Applied Cutaneous Physiology, Department of Dermatology, Venerology and Allergology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

Humboldt University of Berlin

Free University of Berlin

Charité - Universitätsmedizin Berlin

⁵

Georgia Institute of Technology, Atlanta, USA |

⁶

Institut für Hygiene und Umweltmedizin, Universitätsmedizin Greifswald, Ferdinand-Sauerbruch-Straße, Greifswald, Germany |

Publication type: Journal Article

Publication date: 2021-07-19

Springer Nature

Scientific Reports

scimago Q1

wos Q1

SJR: 0.874

CiteScore: 6.7

Impact factor: 3.9

ISSN: 20452322

DOI: 10.1038/s41598-021-94070-2

Copy DOI

PubMed ID: 34282225

Multidisciplinary

Abstract

Multiresistant pathogens such as methicillin-resistant Staphylococcus aureus (MRSA) cause serious postoperative infections. A skin tolerant far-UVC (< 240 nm) irradiation system for their inactivation is presented here. It uses UVC LEDs in combination with a spectral filter and provides a peak wavelength of 233 nm, with a full width at half maximum of 12 nm, and an irradiance of 44 µW/cm2. MRSA bacteria in different concentrations on blood agar plates were inactivated with irradiation doses in the range of 15–40 mJ/cm2. Porcine skin irradiated with a dose of 40 mJ/cm2 at 233 nm showed only 3.7% CPD and 2.3% 6-4PP DNA damage. Corresponding irradiation at 254 nm caused 11–14 times higher damage. Thus, the skin damage caused by the disinfectant doses is so small that it can be expected to be compensated by the skin's natural repair mechanisms. LED-based far-UVC lamps could therefore soon be used in everyday clinical practice to eradicate multiresistant pathogens directly on humans.

Found

1 citation

Pavlov Yuri

DSc in Engineering, associate professor

63 publications, 425 citations, 3 reviews

h-index: 13

A.N. Frumkin Institute of Physical Chemistry and Electrochemistry of the Russian Academy of Sciences

Research interests

Radiation

1 citation

Isayev Rafael

🤝

16 publications, 72 citations

h-index: 5

National Research Nuclear University MEPhI

Joint Institute for Nuclear Research

Research interests

Corrosion

Ion implantation

Ion-surface interaction

Metals and alloys

Physical vapor deposition

1 citation

Vasilev Anton

🤝

61 publications, 782 citations

h-index: 17

National University of Science & Technology (MISiS)

Research interests

Physics of semiconductors

Power electronics

Wide-band semiconductors

1 citation

Aleksanyan Luiza

PhD in Physics and Mathematics

21 publications, 165 citations

h-index: 8

National University of Science & Technology (MISiS)

Wide-band semiconductors

1 citation

Schemerov Ivan

PhD in Engineering

176 publications, 1 073 citations

h-index: 16

European Organization for Nuclear Research

National University of Science & Technology (MISiS)

École Polytechnique Fédérale de Lausanne

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Glaab J. et al. Skin tolerant inactivation of multiresistant pathogens using far-UVC LEDs // Scientific Reports. 2021. Vol. 11. No. 1. 14647

GOST all authors (up to 50) Copy

Glaab J., Lobo Ploch N., Cho H. K., Filler T., Gundlach H., Guttmann M., Hagedorn S., Lohan S. B., Mehnke F., Schleusener J., Sicher C., Sulmoni L., Wernicke T., Wittenbecher L., Woggon U., Zwicker P., Kramer A., Meinke M. C., Kneissl M., Weyers M., Winterwerber U., Einfeldt S. Skin tolerant inactivation of multiresistant pathogens using far-UVC LEDs // Scientific Reports. 2021. Vol. 11. No. 1. 14647

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RIS Copy

TY - JOUR

DO - 10.1038/s41598-021-94070-2

UR - https://doi.org/10.1038/s41598-021-94070-2

TI - Skin tolerant inactivation of multiresistant pathogens using far-UVC LEDs

T2 - Scientific Reports

AU - Glaab, Johannes

AU - Lobo Ploch, Neysha

AU - Cho, Hyun Kyong

AU - Filler, Thomas

AU - Gundlach, Heiko

AU - Guttmann, Martin

AU - Hagedorn, Sylvia

AU - Lohan, Silke B.

AU - Mehnke, Frank

AU - Schleusener, Johannes

AU - Sicher, Claudia

AU - Sulmoni, Luca

AU - Wernicke, Tim

AU - Wittenbecher, Lucas

AU - Woggon, Ulrike

AU - Zwicker, Paula

AU - Kramer, Axel

AU - Meinke, Martina C.

AU - Kneissl, Michael

AU - Weyers, Markus

AU - Winterwerber, Ulrike

AU - Einfeldt, Sven

PY - 2021

DA - 2021/07/19

PB - Springer Nature

IS - 1

VL - 11

PMID - 34282225

SN - 2045-2322

ER -

BibTex

Cite this

BibTex (up to 50 authors) Copy

@article{2021_Glaab,

author = {Johannes Glaab and Neysha Lobo Ploch and Hyun Kyong Cho and Thomas Filler and Heiko Gundlach and Martin Guttmann and Sylvia Hagedorn and Silke B. Lohan and Frank Mehnke and Johannes Schleusener and Claudia Sicher and Luca Sulmoni and Tim Wernicke and Lucas Wittenbecher and Ulrike Woggon and Paula Zwicker and Axel Kramer and Martina C. Meinke and Michael Kneissl and Markus Weyers and Ulrike Winterwerber and Sven Einfeldt},

title = {Skin tolerant inactivation of multiresistant pathogens using far-UVC LEDs},

journal = {Scientific Reports},

year = {2021},

volume = {11},

publisher = {Springer Nature},

month = {jul},

url = {https://doi.org/10.1038/s41598-021-94070-2},

number = {1},

pages = {14647},

doi = {10.1038/s41598-021-94070-2}

}

Publisher

Springer Nature

Journal

Scientific Reports

scimago Q1

wos Q1

SJR

0.874

CiteScore

6.7

Impact factor

3.9

ISSN

20452322 (Print, Electronic)