Open Access
Open access
Springer Nature
Scientific Reports
,  volume 13 ,  issue 1 ,  publication number 17653

From himachalenes to trans-himachalol: unveiling bioactivity through hemisynthesis and molecular docking analysis

A Faris 1
, 
Y Edder 1
, 
I. Louchachha 1
, 
I Ait Lahcen 1
, 
K Azzaoui 2
, 
B. HAMMOUTI 3
, 
M. Merzouki 4
, 
A. Challioui 4
, 
B Boualy 5
, 
A. Karim 1
, 
G Hanbali 1
, 
S Jodeh 6
1
 
2
 
3
 
Euro-Mediterranean University of Fes, Fez, Morocco | 
4
 
Laboratoire de Chimie Appliquée et Environnement - Equipe Chimie Organique Macromoléculaire et Phytochimie, Faculté des Sciences, Université Mohammed Ier, Oujda, Morocco | 
5
 
6
 
Department of Chemistry, AN-najah National University, Nablus, Palestine | 
Publication type: Journal Article
Publication date: 2023-10-17
Springer Nature
scimago Q1
wos Q1
SJR: 0.874
CiteScore: 6.7
Impact factor: 3.9
ISSN: 20452322
Multidisciplinary
Abstract

In this study, we report the first total hemisynthesis of trans-himachalol sesquiterpene, a stereoisomer of the natural cis-himachalol isolated from Cedrus atlantica essential oils, from himachalenes mixture in five steps. Reactions conditions were optimized and structures of the obtained compounds were confirmed by IR, mass spectra, 1H, and 13C NMR. The synthesized compounds were investigated for potential activities on various isolated smooth muscles and against different neurotransmitters using molecular docking. The results show that the synthesized compounds display high affinities towards the active site of the protein 7B2W and the compounds exhibit promising activities on various isolated smooth muscles and against different neurotransmitters.

Found 
Found 

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GOST |
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GOST Copy
Faris A. et al. From himachalenes to trans-himachalol: unveiling bioactivity through hemisynthesis and molecular docking analysis // Scientific Reports. 2023. Vol. 13. No. 1. 17653
GOST all authors (up to 50) Copy
Faris A., Edder Y., Louchachha I., Lahcen I. A., Azzaoui K., HAMMOUTI B., Merzouki M., Challioui A., Boualy B., Karim A., Hanbali G., Jodeh S. From himachalenes to trans-himachalol: unveiling bioactivity through hemisynthesis and molecular docking analysis // Scientific Reports. 2023. Vol. 13. No. 1. 17653
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1038/s41598-023-44652-z
UR - https://doi.org/10.1038/s41598-023-44652-z
TI - From himachalenes to trans-himachalol: unveiling bioactivity through hemisynthesis and molecular docking analysis
T2 - Scientific Reports
AU - Faris, A
AU - Edder, Y
AU - Louchachha, I.
AU - Lahcen, I Ait
AU - Azzaoui, K
AU - HAMMOUTI, B.
AU - Merzouki, M.
AU - Challioui, A.
AU - Boualy, B
AU - Karim, A.
AU - Hanbali, G
AU - Jodeh, S
PY - 2023
DA - 2023/10/17
PB - Springer Nature
IS - 1
VL - 13
PMID - 37848506
SN - 2045-2322
ER -
BibTex
Cite this
BibTex (up to 50 authors) Copy
@article{2023_Faris,
author = {A Faris and Y Edder and I. Louchachha and I Ait Lahcen and K Azzaoui and B. HAMMOUTI and M. Merzouki and A. Challioui and B Boualy and A. Karim and G Hanbali and S Jodeh},
title = {From himachalenes to trans-himachalol: unveiling bioactivity through hemisynthesis and molecular docking analysis},
journal = {Scientific Reports},
year = {2023},
volume = {13},
publisher = {Springer Nature},
month = {oct},
url = {https://doi.org/10.1038/s41598-023-44652-z},
number = {1},
pages = {17653},
doi = {10.1038/s41598-023-44652-z}
}