Nature Reviews Materials

, volume 2 , issue 10 , publication number 17056

Tools for translation: non-viral materials for therapeutic mRNA delivery

Khalid A Hajj ¹

Kathryn A. Whitehead ^{1, 2}

Hide authors affiliations Show authors affiliations: 2 affiliations

Department of Chemical Engineering, Carnegie Mellon University, Pittsburgh, USA |

Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, USA |

Publication type: Journal Article

Publication date: 2017-09-12

Springer Nature

Nature Reviews Materials

scimago Q1

wos Q1

SJR: 19.430

CiteScore: 105.5

Impact factor: 86.2

ISSN: 20588437

DOI: 10.1038/natrevmats.2017.56

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Materials Chemistry

Surfaces, Coatings and Films

Electronic, Optical and Magnetic Materials

Biomaterials

Energy (miscellaneous)

Abstract

In recent years, messenger RNA (mRNA) has come into the spotlight as a versatile therapeutic with the potential to prevent and treat a staggering range of diseases. Billions of dollars have been invested in the commercial development of mRNA drugs, with ongoing clinical trials focused on vaccines (for example, influenza and Zika viruses) and cancer immunotherapy (for example, myeloma, leukaemia and glioblastoma). Although significant progress has been made in the design of in vitro-transcribed mRNA that retains potency while minimizing unwanted immune responses, the widespread use of mRNA drugs requires the development of safe and effective drug delivery vehicles. In this Review, we provide an overview of the field of mRNA therapeutics and describe recent advances in the development of synthetic materials that encapsulate and deliver mRNA payloads. This Review summarizes recent advances in the field of mRNA therapeutics. The synthetic materials that encapsulate and deliver mRNA payloads are described, alongside an overview of commercial development of mRNA drugs.

Found

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Weiskirchen Ralf

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Deviatkin Andrei

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PhD in Biological/biomedical sciences

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Lomonosov Moscow State University

Federal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies

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Gubina Nina

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h-index: 3

ITMO University

Saint Petersburg State University

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Hajj K. A., Whitehead K. A. Tools for translation: non-viral materials for therapeutic mRNA delivery // Nature Reviews Materials. 2017. Vol. 2. No. 10. 17056

GOST all authors (up to 50) Copy

Hajj K. A., Whitehead K. A. Tools for translation: non-viral materials for therapeutic mRNA delivery // Nature Reviews Materials. 2017. Vol. 2. No. 10. 17056

RIS |

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RIS Copy

TY - JOUR

DO - 10.1038/natrevmats.2017.56

UR - https://doi.org/10.1038/natrevmats.2017.56

TI - Tools for translation: non-viral materials for therapeutic mRNA delivery

T2 - Nature Reviews Materials

AU - Hajj, Khalid A

AU - Whitehead, Kathryn A.

PY - 2017

DA - 2017/09/12

PB - Springer Nature

IS - 10

VL - 2

SN - 2058-8437

ER -

BibTex

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BibTex (up to 50 authors) Copy

@article{2017_Hajj,

author = {Khalid A Hajj and Kathryn A. Whitehead},

title = {Tools for translation: non-viral materials for therapeutic mRNA delivery},

journal = {Nature Reviews Materials},

year = {2017},

volume = {2},

publisher = {Springer Nature},

month = {sep},

url = {https://doi.org/10.1038/natrevmats.2017.56},

number = {10},

pages = {17056},

doi = {10.1038/natrevmats.2017.56}

}

Publisher

Springer Nature

Journal

Nature Reviews Materials

scimago Q1

wos Q1

SJR

19.430

CiteScore

105.5

Impact factor

86.2

ISSN

20588437 (Electronic)